A5055547536- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cognitive Abilities and Testing
- Epilepsy research and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Birth, Development, and Health
- Fetal and Pediatric Neurological Disorders
- Morphological variations and asymmetry
- Williams Syndrome Research
- Advanced MRI Techniques and Applications
- Cardiovascular Issues in Pregnancy
- Pelvic floor disorders treatments
- Neurobiology of Language and Bilingualism
- Anesthesia and Neurotoxicity Research
- Health, Environment, Cognitive Aging
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Neuropharmacology Research
- Mycobacterium research and diagnosis
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Face Recognition and Perception
- Congenital gastrointestinal and neural anomalies
University of Turku
2018-2024
Turku Centre for Computer Science
2024
Åbo Akademi University
2024
Turku University Hospital
2021-2023
Background: Birth is a traumatic event with molding forces directed to the fetal skull, which may result in intracranial hemorrhages. However, knowledge on prevalence and risk factors of incidental brain magnetic resonance imaging (MRI) findings infants still inconclusive. Methods: The nature MRI were assessed birth cohort 175 asymptomatic infants. role delivery method as well other potential for hemorrhages evaluated. underwent 3T at age 2-5 weeks, neurological status an finding was...
Abstract The rapid white matter (WM) maturation of first years life is followed by slower yet long‐lasting development, accompanied learning more elaborate skills. By the age 5 years, behavioural and cognitive differences between females males, functions associated with brain lateralization such as language skills are appearing. Diffusion tensor imaging (DTI) can be used to quantify fractional anisotropy (FA) within WM increasing values correspond advancing development. To investigate normal...
Prenatal and postnatal maternal psychological distress predicts various detrimental consequences on social, behavioral, cognitive development of offspring, especially in girls. Maturation white matter (WM) continues from prenatal into adulthood is thus susceptible to exposures both before after birth.
Developing accurate subcortical volumetric quantification tools is crucial for neurodevelopmental studies, as they could reduce the need challenging and time-consuming manual segmentation. In this study, accuracy of two automated segmentation tools, FSL-FIRST (with three different boundary correction settings) FreeSurfer, were compared against hippocampus nuclei, including amygdala, thalamus, putamen, globus pallidus, caudate nucleus accumbens, using correlation analyses in 80 5-year-olds....
Pediatric neuroimaging is a quickly developing field that still faces important methodological challenges. images usually have more motion artifact than adult images. The can cause visible errors in brain segmentation, and one way to address it manually edit the segmented Variability editing quality control protocols may complicate comparisons between studies. In this article, we describe detail semiautomated segmentation protocol of structural was used FinnBrain Birth Cohort Study relies on...
Regulatory T cells (Tregs) are central in controlling immune responses, and dysregulation of their function can lead to autoimmune disorders or cancer. Despite extensive studies on Tregs, the basis epigenetic regulation human Treg development is incompletely understood. Long intergenic noncoding RNAs (lincRNA)s important for shaping maintaining landscape different cell types. In this study, we identified a gene chromosome 6p25.3 locus, encoding lincRNA, that was up-regulated during early...
Methodological aspects and effects of different imaging parameters on DTI (diffusion tensor imaging) results their reproducibility have been recently studied comprehensively in adult populations. Although MR children's brains has become common, less interest focussed researching whether adult-based optimised pre-processing protocols can be reliably applied to paediatric Furthermore, scalar values preschool aged children are rarely reported. We gathered a dataset from 5-year-old (N = 49)...
The quality of mother-child interaction, especially maternal sensitivity in caregiving behavior, plays an important role a child's later socioemotional development. Numerous studies have indicated associations between poor interaction and offspring brain structure function, but more knowledge on how variation the characteristics early is associated with children's function needed. We investigated whether at 8 or 30 months functional connectivity 5 years age based FinnBrain Birth Cohort Study...
Abstract The human brain develops dynamically during early childhood, when the child is sensitive to both genetic programming and extrinsic exposures. Recent studies have found links between prenatal life environmental factors, family demographics cortical morphology in newborns measured by surface area, volume thickness. Here this magnetic resonance imaging study, we evaluated whether a similar set of variables associates with area volumes sample 170 healthy 5-year-olds from FinnBrain Birth...
Abstract Diffusion tensor imaging (DTI) has provided great insights into the microstructural features of developing brain. However, DTI images are prone to several artifacts and reliability scalars is paramount importance for interpreting generalizing findings studies, especially in younger population. In this study, we investigated intrascan test–retest repeatability four scalars: fractional anisotropy (FA), mean diffusivity (MD), axial (AD), radial (RD) 5‐year‐old children ( N = 67) with...
Abstract Non-verbal cognitive ability predicts multiple important life outcomes, e.g., school and job performance. It has been associated with parieto–frontal cortical anatomy in prior studies adult adolescent populations, while young children have received relatively little attention. We explored the associations between non-verbal 165 5-year-old participants (mean scan age 5.40 years, SD 0.13; 90 males) from FinnBrain Birth Cohort study. T1-weighted brain magnetic resonance images were...
Non-verbal cognitive ability predicts multiple important life outcomes, for example, school and job performance. It has been associated with parieto-frontal cortical anatomy in prior studies adult adolescent populations, while young children have received relatively little attention. We explored the associations between non-verbal 165 5-year-old participants (mean scan age 5.40 years, SD 0.13; 90 males) from FinnBrain Birth Cohort study. T1-weighted brain magnetic resonance images were...
Abstract Developing accurate subcortical volumetric quantification tools is crucial for neurodevelopmental studies, as they could reduce the need challenging and time-consuming manual segmentation. In this study accuracy of two automated segmentation tools, FSL-FIRST (with three different boundary correction settings) FreeSurfer were compared against nuclei, including hippocampus, amygdala, thalamus, putamen, globus pallidus, caudate nucleus accumbens, using correlation analyses in 80...
Abstract Maternal pre- and postnatal depressive symptoms influence brain development in offspring. may affect child through intrauterine conditions as well ways of parenting mother–child interaction. This study investigated whether maternal are associated with child’s whole regional homogeneity (ReHo) seed-based connectivity the bilateral amygdala at 5 years age based on sample available from FinnBrain Birth Cohort Study (N = 68; 28 boys, 40 girls). were assessed Edinburgh Postnatal...
The aim of this study was to explore the associations between an aspect self-regulation (SR), effortful control (EC), and cortical brain structure in 5-year-old children. Efficient EC is a predictor many attributes important outcomes life, such as social-emotional functioning, psychiatric somatic health, finance, criminal activity. early correlates are not widely studied, while better understanding them would aid recognizing individuals at risk for maladaptive outcomes. Participants (N =...
Abstract Pediatric neuroimaging is a quickly developing field that still faces important methodological challenges. One key challenge the use of many different atlases, automated segmentation tools, manual edits in semiautomated protocols, and quality control which complicates comparisons between studies. In this article, we present our protocol using FreeSurfer v6.0, ENIGMA consortium software, was used FinnBrain Birth Cohort Study. We dichotomous rating scale for inclusion exclusion...
ABSTRACT The rapid white matter (WM) maturation of first years life is followed by slower yet long-lasting development, accompanied learning more elaborate skills. By the age five years, behavioural and cognitive differences between females males, functions associated with brain lateralization such as language skills are appearing. Diffusion tensor imaging (DTI) can be used to quantify fractional anisotropy (FA) within WM increasing values correspond advancing development. To investigate...
Abstract The development of face processing system is paramount for social interaction and communication skills. Eye-tracking provides a viable means to investigate even in very young children can be used derive indices affective biases that are adaptive supporting preparedness emotional encoding. neural correlates early-emerging attentional have not been explored. In the current study, we gathered diffusion tensor imaging (DTI) eye-tracking data (attention disengagement from neutral, happy,...
Abstract The human brain develops dynamically during early childhood, when the child is sensitive to both genetic programming and extrinsic exposures. Recent studies have found links between prenatal life environmental factors, family demographics cortical morphology in newborns measured by surface area, volume thickness. Here this magnetic resonance imaging study, we evaluated whether a similar set of variables associates with area volumes sample 170 healthy 5-year-olds from FinnBrain Birth...