A5007788165- CRISPR and Genetic Engineering
- Adenosine and Purinergic Signaling
- Photoreceptor and optogenetics research
- Neurological Complications and Syndromes
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
University of Lausanne
2025
Max Delbrück Center
2017
Microglial cells invade the brain as amoeboid precursors and acquire a highly ramified morphology in postnatal brain. Microglia express all essential purinergic elements such receptors, nucleoside transporters ecto-enzymes, including CD39 (NTPDase1) CD73 (5'-nucleotidase), which sequentially degrade extracellular ATP to adenosine. Here, we show that constitutive deletion of or both caused an inhibition microglia phenotype with reduction length processes, branching frequency number...
Three-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines allow in vitro studies on progenitors photoreceptors their developmental dynamics or properties test therapeutic approaches. The isolation pure progenitor populations photoreceptor precursors may serve drug, gene, therapy development. Here, we generated dual-reporter mouse embryonic line Crx-GFP;Rax-mCherry enabling visualization from...