A5043216135- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- COVID-19 Clinical Research Studies
- Helminth infection and control
- Essential Oils and Antimicrobial Activity
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Fish Biology and Ecology Studies
- Vector-borne infectious diseases
- Long-Term Effects of COVID-19
- Phagocytosis and Immune Regulation
- Biochemical and Structural Characterization
- Vector-Borne Animal Diseases
- Animal Diversity and Health Studies
- Viral Infections and Vectors
- Natural product bioactivities and synthesis
- Parasitic Infections and Diagnostics
- Natural Antidiabetic Agents Studies
- Child Nutrition and Water Access
- Listeria monocytogenes in Food Safety
- Calcium signaling and nucleotide metabolism
- Phytochemical compounds biological activities
- Advanced Glycation End Products research
- Parasitic Diseases Research and Treatment
- Electrochemical sensors and biosensors
Umm al-Qura University
2006-2023
University of Nottingham
2006-2012
Abstract Background The antiprotozoal and antioxidant activities of Viola tricolor Laurus nobilis have been reported recently. Thus, the existing study pursued to assess growth inhibition effect methanolic extract V. (MEVT) acetonic L. (AELN) against five Babesia parasites Theileria equi in vitro vivo. Results MEVT AELN suppressed bovis , B. bigemina divergens caballi T. at half-maximal inhibitory concentration (IC 50 ) values 75.7 ± 2.6, 43.3 1.8, 67.6 2.8 48 3.8, 54 2.1 μg/mL, 86.6 8.2,...
Portulacaria afra Jacq (Portulacaceae) is a medicinal plant used traditionally in the treatment of pain and inflammation. This study aimed to evaluate phytochemical composition, toxicity, antinociceptive, enzyme inhibition potential P. afra. The methanol extract (PAME) was prepared through maceration fractionated with ethanol fraction (ETPA). Both PAME ETPA were found be rich total phenolic (TPC) flavonoid contents (TFC). Similarly, showed highest antioxidant ABTS 93.16 ± 0.05 mg TE /g dry...
Berberis vulgaris (B. vulgaris) and Rhus coriaria (R. coriaria) have been documented to various pharmacologic activities. The current study assessed the in vitro as well vivo inhibitory efficacy of a methanolic extract B. (MEBV) an acetone R. (AERC) on six species piroplasm parasites. drug-exposure viability assay was tested three different cell lines, namely mouse embryonic fibroblast (NIH/3T3), Madin-Darby bovine kidney (MDBK) human foreskin (HFF) cells. Qualitative phytochemical...
Coronavirus disease 2019 (COVID-19) a global infectious caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) affects various organs, primarily the system, and presented with pulmonary manifestations such as lung injury (ALI) distress syndrome. Levamisole (LVM) is an anthelminthic drug; it has immune-modulating effects through induction of type 1 immune response. Based on these findings several recent studies highlighted that LVM might be effective in preventing treating SARS-CoV-2...
Atranorin (ATR), is a compound with multidirectional biological activity under different in vitro and vivo conditions it effective as an antibacterial, antiviral, antiprotozoal anti-inflammatory agent. In the current study, well chemotherapeutic effect of ATR its combined efficacy existing antibabesial drugs (diminazene aceturate (DA), atovaquone (AV) clofazimine (CF)) were investigated on six species piroplasm parasites. suppressed B. bovis, bigemina, divergens, caballi T. equi...
Schistosomiasis and soil-transmitted helminthiasis (STH) are neglected tropical diseases (NTDs) that cause chronic infections ill health. The study was carried out to determine the current infection status risk factors associated with Schistosoma haematobium helminth coinfection among school children in Biase Local Government Area (LGA), Cross River State, Nigeria. A cross-sectional out. Urine fecal samples were randomly collected from 630 six villages of LGA. sedimentation Kato-Katz...
Hepatic lipidosis (HL) is a serious metabolic disorder that affects transient high-producing dairy cows. However, there are many laboratory methods could help in the assessment of HL cows, definite diagnosis disease under field conditions remains challenge because non-specificity clinical parameters. The aim study was to investigate utility serum biomarkers, and ultrasonography (US) measurement diagnose Forty Holstein cows underwent physical examination were divided into three groups:...
Abstract Background The Mount Cameroon area has experienced a 57.2% decline in confirmed malaria cases between 2006 and 2013 with the implementation of different control measures but, disease is still public health concern. objective study was to assess burden asymptomatic sub-microscopic Plasmodium infection, altitudinal influence on it, their effect haematological parameters as well identify risk factors infection. Methodology A cross-sectional community-based survey involving 1319...
In Uganda, bovine babesiosis continues to cause losses the livestock industry because of shortages cheap, quick, and reliable diagnostic tools guide prescription measures. this study, presence antibodies Babesia bigemina bovis in 401 blood samples obtained from eastern central areas Uganda were detected using enzyme-linked immunosorbent assays (ELISAs) immunochromatographic test strips (ICTs). The ELISA ICT used targeted B. C-terminal rhoptry-associated protein (RAP-1/CT17) spherical body...
Piroplasmosis treatment has been based on the use of imidocarb dipropionate or diminazene aceturate (DA), however, their toxic effects. Therefore, discovery new drug molecules and targets is urgently needed. Cryptolepine (CRY) a pharmacologically active plant alkaloid; it significant potential as an antiprotozoal antibacterial under different in vitro vivo conditions. The fluorescence assay was used for evaluating inhibitory effect CRY four Babesia species Theileria equi vitro,...
Abstract Although hookworms are known to stimulate inflammatory responses in the intestinal mucosa of their hosts, there is little quantitative data on this aspect infection. Here we report results experiments conducted hamsters infected with Ancylostoma ceylanicum . Infection resulted a marked increase goblet cells mucosa, which was dependent number adult worms present and sustained as long persisted (over 63 days) but returned baseline levels within 7 days removal by treatment ivermectin....
We assessed the mucosal response of previously infected hamsters to low-dose challenge with hookworm, Ancylostoma ceylanicum. Hamsters were assigned five treatment groups (Groups 1-5, respectively): naïve, controls; uninterrupted primary infection from day 0; infected, but treated anthelmintic on 35 p.i.; control group given only second 63; initially, cleared worms and then challenged. Animals culled days 73 94 (10 31 after challenge), additional animals Group 5 80 87. The results showed...
Abstract An experiment was conducted to assess the mucosal response low-dose superimposed challenge with Ancylostoma ceylanicum . Hamsters were assigned five treatment groups (1–5 respectively): naïve controls; primary immunizing infection immunized, anthelmintic–treated, challenged group; group. Group 4 hamsters resistant challenge, whereas most of inoculum larvae established in 5. Villus height and crypt depth measurements initially markedly divergent between these two but over time...
Hookworms are known to cause marked changes the intestinal mucosa, especially in relation erosion of villi. However, since development enteropathy has not been examined thoroughly through quantitative experiments on infected animals, results conducted hamsters with Ancylostoma ceylanicum reported. Changes architecture were first apparent between 12 and 14 days after infection, then increased intensity for 3-4 weeks, persisting as long worms present (>63 days). Following height villi declined...
A rabian camels (Camelus dromedarious) have been do- mesticated 5,000 years ago, and throughout these they played an important role in the camel owners' life.Arabian (one humped camel) has special anatomical physiological criteria that enable him acclimatizing to desert ecosystem (Rabana et al., 2011).With increase of human population insufficiency food production Africa parts Asia, it be-research
Abstract An experiment was carried out to assess mucosal changes in hamsters exposed weekly repeated low-intensity infections with the hookworm Ancylostoma ceylanicum . The included control groups of naïve, uninfected and that received a single-pulse primary infection. Changes intestinal architecture density inflammatory cells mucosa, including mast cells, goblet Paneth eosinophils were examined relation burdens. As infection, responded marked populations cells. However, there distinct...