A5018434283- Parasitic Diseases Research and Treatment
- vaccines and immunoinformatics approaches
- Insects and Parasite Interactions
- Parasite Biology and Host Interactions
- Monoclonal and Polyclonal Antibodies Research
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Malaria Research and Control
- Hemoglobinopathies and Related Disorders
- Virology and Viral Diseases
- Gastrointestinal motility and disorders
- Heat shock proteins research
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Child Nutrition and Water Access
- Blood transfusion and management
- Global Maternal and Child Health
- Telomeres, Telomerase, and Senescence
- Organ Donation and Transplantation
- Blood donation and transfusion practices
- Transgenic Plants and Applications
- Genetics, Aging, and Longevity in Model Organisms
Drexel University
2025
University of Buea
2019-2024
Vrije Universiteit Brussel
2020-2023
Abstract Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and microfilaria stages of parasite’s life cycle would be invaluable to achieve current goal. There are several observations that make possibility developing against likely. For example, despite being exposed transmission rates infection, 1 5%...
Onchocerciasis is a skin and eye disease that exerts heavy socio-economic burden, particularly in sub-Saharan Africa, region which harbours greater than 96% of either infected or at-risk populations. The elimination plan for the currently challenged by many factors including amongst others; potential emergence resistance to main chemotherapeutic agent, ivermectin (IVM). Novel tools, preventative therapeutic vaccines, could provide additional impetus tool portfolio. Several observations both...
Tuberculosis (TB) remains a major cause of ill health and one the leading causes death worldwide, with about 1.25 million deaths estimated in 2023. Control measures have focused principally on early diagnosis, treatment active TB, vaccination. However, widespread emergence anti-tuberculosis drug resistance public threat to progress made global TB care control. Also, Bacille Calmette-Guérin (BCG) vaccine, only licensed vaccine against children, has been use for over century, there...
Tuberculosis (TB) remains a major cause of ill health and one the leading causes death worldwide, with about 1.25 million deaths estimated in 2023. Control measures have focused principally on early diagnosis, treatment active TB, vaccination. However, widespread emergence anti-tuberculosis drug resistance public threat to progress made global TB care control. Moreover, Bacillus Calmette-Guérin (BCG) vaccine, only licensed vaccine against children, has been use for over century, there...
Onchocerciasis, caused by the filarial worm Onchocerca volvulus, remains a major public health challenge due to limitations of ivermectin-based control strategies, thereby, highlighting need for more innovative tools like vaccines. This study investigated safety and immunogenicity novel multi-epitope chimeric antigen, OvMANE1 formulated with Freunds adjuvant, in BALB/c mice. Following mice immunization at three time points 2-week intervals, adjuvanted-OvMANE1 exhibited promising profile,...
Malaria remains a significant public health challenge, particularly in endemic regions. The extensive genetic diversity of Plasmodium falciparum (Pf) complicates outbreak prediction and transmission control. One its most polymorphic markers, merozoite surface protein 2 (MSP2), presents potential target for molecular surveillance. This cross-sectional study, conducted at King Faisal Hospital Rwanda (KFHR) from October 2021 to June 2023, assessed MSP2′s utility malaria prediction. PfMSP2 was...
Onchocerciasis is a Neglected Tropical Disease that has significant socioeconomic impact, especially in Sub-Saharan Africa. Numerous reports indicate the Expanded Special Project for Elimination of Diseases needs novel diagnostic tools before achieving its goal successful elimination onchocerciasis The current tests are either invasive, insensitive, or not applicable field and about 25% persons infected cannot mount immune responses against single antigen used only approved Ov-16 serological...
Abstract Background The Mount Cameroon area has experienced a 57.2% decline in confirmed malaria cases between 2006 and 2013 with the implementation of different control measures but, disease is still public health concern. objective study was to assess burden asymptomatic sub-microscopic Plasmodium infection, altitudinal influence on it, their effect haematological parameters as well identify risk factors infection. Methodology A cross-sectional community-based survey involving 1319...
The public health goal of onchocerciasis in Africa has advanced from control to elimination. In this light, accurate diagnosis is necessary determine treatment endpoints and confirm elimination, as well conduct surveillance for the identification any possible recrudescence disease. Currently, monitoring elimination relies on Ov-16 test. However, test unable discriminate between past active infections. Furthermore, about 15–25% infected persons are reported be negative test, giving a...
The enormity of the public health burden onchocerciasis motivated creation various large-scale control programs that have depended principally on mass treatment endemic communities with ivermectin for elimination disease. Parasitological evaluation Onchocerca species in West Region Cameroon indicates significant progress interruption parasite transmission some under treatment. However, to verify complete onchocerciasis, entomological assessment through O-150 PCR poolscreen black flies is...
Onchocerciasis (river blindness) is a debilitating tropical disease that causes significant eye and skin damage, afflicting millions worldwide. As global efforts shift from management to elimination, vaccines have become crucial supplementary tools. The Vaccine for Africa (TOVA) Initiative was established in 2015, advance at least one vaccine candidate initially targeting onchocerciasis infants children below 5 years of age, through Phase I human trials by 2025. Notably, Ov -RAL-2 -103...
The current serological test for human onchocerciasis relies on IgG4 reactivity against the parasite Ov-16 antigen, with reported sensitivities of only 60-80%. As control programs move from to elimination, it is imperative identify novel molecules that could improve serodiagnosis reliability this disease. In study we compared sensitivity total IgG OvMANE1-a chimeric antigen previously identified as a potential biomarker onchocerciasis-with an antibody detect Onchocerca volvulus infection in...
Almost a decade ago, it was recognized that the global elimination of onchocerciasis by 2030 will not be feasible without, at least, an effective prophylactic and/or therapeutic vaccine to complement chemotherapy and vector control strategies. Recent advances in computational immunology (immunoinformatics) have seen design novel multi-epitope candidates which are however yet evaluated clinical settings. Still, continued research increase pool candidates, therefore chance success trial...
In low- and middle-income countries, undernutrition often co-exists with intestinal parasites, especially Soil Transmitted Helminth (STH) infections in children. The collective impact of both conditions result can exacerbate the general poor health status A cross-sectional survey 422 mother-child (12–59 months old) pairs from 14 villages District Ndelele, East Region Cameroon, was carried out to assess magnitude correlates parasites. Socio-demographic data were collected mothers...
Abstract Onchocerciasis is a devastating tropical disease that causes severe eye and skin lesions. As global efforts shift from control to elimination, prophylactic/therapeutic vaccines have emerged as alternative elimination tools. Notably, Ov -RAL-2 -103 antigens shown great promise in preclinical studies plans are underway for clinical trials. Here, we predict the immunogenicity other vaccine-related parameters both using immunoinformatics, potential vaccine candidates against...
Abstract Background: The Mount Cameroon area has experienced a 57.2% decline in confirmed malaria cases between 2006 and 2013 with the implementation of different control measures but, disease is still public health concern. objective study was to assess burden asymptomatic sub-microscopic Plasmodium infection, altitudinal influence on it, their effect haematological parameters as well identify risk factors infection. Methodology: A cross-sectional community-based survey involving 1319...