Efficient presentation of mutant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune-mediated killing cancer cells. According to recent reports, patient HLA-I genotypes can impact efficacy immunotherapy, and somatic loss heterozygosity has been established as a factor in immune evasion. While global deregulated expression also reported different tumor types, role allele-specific - that is, preferential RNA specific alleles not fully characterized...

Patients with lung cancer receive treatment according to National Cancer Comprehensive Network (NCCN) standards. However, disease recurrence is reported in about 30% of patients during the first five years. Our study aimed establish independent predictors recurrence.104 definitive for non-small-cell carcinoma receiving standard adjuvant chemotherapy period 2014-2018 our center were retrospectively reviewed. The prognostic significance routine immunohistochemical (IHC) markers was...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Moskalenko Y, Kurochkin A, Vynnychenko I, et al. Toluidine blue for the detection of sentinel lymph nodes in patients with thyroid cancer. Contemporary Oncology/Współczesna Onkologia. 2023. doi:10.5114/wo.2022.124585. APA Moskalenko, Y., Kurochkin, A., Vynnychenko, I., Kravets, O., Piddubnyi, & R. (2023). https://doi.org/10.5114/wo.2022.124585 Chicago Yuliia, Andrii Ihor Oleksandr Artem Roman and Potapov....

Pathological biomineralization can be found in some gallbladder (GB) diseases such as chronic calculous cholecystitis (CCCh), cancer (GBC) and porcelain (PGB). The aim of the work was to analyze morphology pathological GB tissue CCCh, GBC PGB. Five cases PGB, 10 samples CCCh 5 with were selected for this study. All examined by histology, histochemistry scanning electron microscopy X-ray diffraction. diffraction mineral deposits PGB wall concretions revealed their different composition. had...

Introduction. Meckel's diverticulum (MD) is a congenital anomaly of the gastrointestinal tract. In most cases, uncomplicated DM silent. It mainly diagnosed when complications arise or accidentally during diagnostic procedures surgical interventions. A recognised effective method laparoscopy, which allows to assess localisation and degree pathological changes in diverticulum. Treatment complicated surgical. The volume surgery depends on diameter diverticulum, nature complications, prevalence...

Abstract. Aim. Study of the effectiveness preventive measures in development wound complications hernioplasty patients with large ventral hernias who suffer from obesity. Materials and methods. An analysis results treatment 365 had obesity various degrees was carried out. Depending on condition hernia gate, alloplasty performed one three options: «Onlay», «Inlay» or «Sublay» active drainage. A set to prevent local included lowering body mass index; antibiotic prophylaxis complications;...

Introduction. The incidence and features of acute pancreatitis stimulate the scientific community clinicians to look for new antibiotics algorithms their use in treating this disease, which is world's third most frequent surgical disease. Despite this, mortality indicates need better approaches, especially conditions microbial resistance antibiotics, determines urgency problem. objective paper was justify lymphotropic antibacterial therapy as an alternative method treatment based on changes...

The aim: Was following: the improvement of treatment results lower limbs ulcers, caused by diabetes mellitus using our technique platelet-rich plasma application; study features morphological and immunohistochemical changes, effect growth factors on regeneration healing ulcers. Materials methods: 38 patients with trophic ulcers limbs, were involved in study. To assess reparative processes before after PRP, histological immunohystochemical studies biopsy specimen carried out. Results: total...

The article presents an analysis of the meanings corresponding definitions («the mechanism injury», «the specialized knowledge», «competence forensic expert»), describes requirements existing criminal procedural legislation Ukraine relating to performing examinations and status expert, showing that medical examiner without knowledge, skills training in field Biomechanics - one section Biophysics, is not authorized, so he should has no law right give expert opinion on non-medical question...

The article deals with the searching of ways to improve forensic-medical examination injuries face which cause irreparable consequences. reviews current procedural and regulatory requirements for performing such examinations, criteria facial disfigurement, caused by trauma. It is proposed grant right examiner (including a commision experts) finally estimate severity degree in cases clear indubitable posttraumatic disfigurement. This due fact that has special medical knowledge anatomy...

Сумский государственный университет

Objective. To study up the possibilities of improvement treatment results in patients, suffering an acute pancreatitis, using method delivery antibiotic to pancreatic gland. Materials and methods. The authors have proposed conducted experimental investigation on 20 male rats, consisting manners deliver ceftriaxone towards Results. Taking into account enhances antibacterial efficacy gland homogenate, than while other methods, there appear that lymphotropic therapy owes a targeted character...

Global environmental problems are gradually changing climatic conditions in different regions and cause significant warming. As a result, high-water beds, lakes ponds get swamped colonized by blood-sucking mosquitoes, which carriers of number diseases, including dirofilariasis. Manifestations external dirofilariasis may look like ophthalmic, surgical, urological, oncological, dermatological, vascular, psychiatric diseases. The objective manifestation the disease is appearance...

The concept of development the theory design mobile robots for special purposes has been developed. influence road conditions on accuracy manipulators established. Parameters static and dynamic characteristics are substantiated by means mathematical modeling. On this basis, Recommendations have developed, which develop main provisions designing purposes, adapted to work with hazardous objects.

Introduction. Treatment of patients with thyroid cancer (TС) clinically undetected metastases to regional lymph nodes remains an unsolved problem modern oncology. The search for reliable diagnostic methods, which underlie the decision perform adequate lymphadenectomy TC, is one priorities oncosurgery. aim research: find effective method intraoperative contrasting sentinel (SLN) in TC using toluidine blue and evaluate its effectiveness. Methods. A study 123 who underwent surgical treatment...

Still composition and volume of rational infusion therapy come into question for patients with urgen abdominal surgical pathology. W ith the purpose estimation efficiency application multicomponent polyionic colloid hyperosmolar solution Gecoton in we are inspect 52 subject to operative intervention. e defined that introduction preparation allowed avoid an electrolyte disbalance at renewal physiological indexes water balance already from a twenty-four hours on background stable system...

The influence of different variants parenteral nutrition (PN) for patients with necrotizing pancreatitis and edematous form acute are analyzed. It is shown that the best method most use a mixture “three in one” (if there contraindications to fat emulsion should apply “two one”). Using reduced number septic complications, faster stabilize hemodynamics laboratory parameters destructive pancreatitis. We can recommend reach target energy requirements at 25–30 kcal/kg ideal body weight per day In...