A5001670924- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Crystallization and Solubility Studies
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Organic and Inorganic Chemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Organic Light-Emitting Diodes Research
- Magnetism in coordination complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Analysis
- Nutrition and Health in Aging
- Metal Alloys Wear and Properties
- Crystallography and molecular interactions
- Dysphagia Assessment and Management
- Crystal structures of chemical compounds
- Catalytic Alkyne Reactions
- Clinical Nutrition and Gastroenterology
- Microstructure and Mechanical Properties of Steels
- Organometallic Complex Synthesis and Catalysis
Fujian Institute of Research on the Structure of Matter
2023-2024
Chinese Academy of Sciences
2016-2024
École Polytechnique Fédérale de Lausanne
2018-2024
Xiamen Institute of Rare-earth Materials
2023-2024
Max Planck Institute for Medical Research
2022-2024
Xiamen University of Technology
2023
First Hospital of Xi'an
2022
Xian Central Hospital
2022
Leibniz Institute for Catalysis
2017
University of Rostock
2017
Considerable progress has been made in the area of copper-mediated C(sp<sup>2</sup>)–H functionalization reactions with assistance chelating directing groups. Due to advantages copper catalysts such as low cost, toxicity, and unique reactivity compared precious metals, they have attracted more attention organic synthesis. This review summarizes recent advances this field according classification 1 Introduction 2 The Pyridine Directing Group 2.1 C–N Bond Formation 2.2 C–O 2.3 C–S 2.4 C–C 2.5...
One long-standing issue in directed C-H functionalization is that either nitrogen or sulfur atoms present heterocyclic substrates may bind preferentially to a transition-metal catalyst rather than the desired directing group. This competitive binding has largely hindered application of late-stage heterocycle drug discovery. Reported here use an oxazoline-based group capable overriding poisoning effect wide range substrates. The potential this pharmaceutical discovery illustrated by...
Abstract The first Lewis acid catalyzed enantioselective ring‐opening desymmetrization of a donor–acceptor meso ‐diaminocyclopropane is reported. copper(II)‐catalyzed Friedel–Crafts alkylation indoles and one pyrrole with an unprecedented delivered enantioenriched, diastereomerically pure urea products, which are structurally related to natural synthetic bioactive compounds. development new ligand through the investigation underexplored subclass bis(oxazoline) ligands was essential for...
Abstract We report an oxidative ring‐opening strategy to transform cyclopropylamides and cyclobutylamides into fluorinated imines. The imines can be isolated in their more stable hemiaminal form, with the fluorine atom installed selectively at γ or δ position. Both inexpensive benzophenone UVA light organic inorganic dyes blue could used as photoredox catalysts promote this process. Various amines were then obtained by nucleophilic attack on hemiaminals one pot, giving access a broad range...
Deuterium labeled compounds find widespread application in life science. Herein, the deuteration of electron-rich (hetero)aromatic employing B(C6F5)3 as catalyst and D2O deuterium source is reported. This protocol highly efficient, simply manipulated, successfully applied 23 substrates including natural neurotransmitter-like melatonin. It assumed that weakening O–D bond ultimately results formation electrophilic D+.
Here we report an aerobic Pd(0) catalyzed C2–H functionalization of indoles and pyrroles with tethered N-methoxylamide as the directing group. A Pd(0)-initiated mechanism overcomes or poisoning effect from a wide range heterocycles including pyridine, pyrimidine, thiazole. The imidazo[1,5-a]indole products are transformed to bioactive analogs after one-step manipulations, demonstrating potential utility this reaction in drug discovery.
Abstract We report an oxidative ring‐opening strategy to transform acyl, sulfonyl or carbamate protected aminocyclopropanes into 1,3‐dielectrophilic carbon intermediates bearing a halide atom (Br, I) and N,O‐acetal. Replacing the alkoxy group of N,O‐acetal can be achieved under acidic conditions through elimination–addition pathway, while substitution halides by nucleophiles done basic S N 2 generating wide range 1,3‐difunctionalized propylamines. A proof concept for asymmetric induction was...
Abstract The first Lewis acid catalyzed enantioselective ring‐opening desymmetrization of a donor–acceptor meso ‐diaminocyclopropane is reported. copper(II)‐catalyzed Friedel–Crafts alkylation indoles and one pyrrole with an unprecedented delivered enantioenriched, diastereomerically pure urea products, which are structurally related to natural synthetic bioactive compounds. development new ligand through the investigation underexplored subclass bis(oxazoline) ligands was essential for...
Diamines are essential building blocks for the synthesis of agrochemicals, drugs, and organic materials, yet their remains challenging, as both nitrogens need to be differentiated diverse substitution patterns (1,2, 1,3, or 1,4) required. We report herein a new strategy giving access 1,2, 1,4 amido azides orthogonally protected diamines based on nitrogen-directed diazidation alkenes, cyclopropanes, cyclobutanes. Commercially available copper thiophene-2-carboxylate (CuTc, 2 mol %) catalyst...
Inorganic–organic hybrid semiconductors based on copper( i ) halide are intriguing luminescent materials possessing great prospects as rare-earth elements (REEs) free phosphors for use in solid-state lighting (SSL).
We report the one-pot synthesis of 4-amino thiochromans using simple aminocyclopropanes and thiophenols through a formal [3+3] annulation reaction. This reaction proceeds under mild conditions with good functional group tolerance. The thiochroman core was formed complete regioselectivity, modification complex drug molecules containing an aminocyclopropane also realized.
Alkynyl compounds are paramount skeletons in pharmaceuticals and natural products, great importance has been attached to its synthesis by organic chemists.Recently, transition-metal-catalyzed C-H alkynylation attracted tremendous interest as a valuable tool for construction of alkynyl compounds.This review gives summary progress having made the field C(sp 2 )-H 3 over last ten years.Keywords alkynylation; activation; alkyne; cross dehydrogen coupling 炔烃化合物是一类重要的医药化工中间体, 被广泛...
Inspired by the Burgess reagent, we report a mild and practical synthesis of primary sulfonamides from electron-rich aromatic compounds using in situ formed N -sulfonylamine as electrophile.
Abstract We report an oxidative ring‐opening strategy to transform cyclopropylamides and cyclobutylamides into fluorinated imines. The imines can be isolated in their more stable hemiaminal form, with the fluorine atom installed selectively at γ or δ position. Both inexpensive benzophenone UVA light organic inorganic dyes blue could used as photoredox catalysts promote this process. Various amines were then obtained by nucleophilic attack on hemiaminals one pot, giving access a broad range...
The effects of deformation amount, temperature and subsequent holding time on the spheroidising process high-carbon-bearing steel containing aluminium were investigated. contents mechanism spheroidisation also Results show that can shorten cycles. High amount induce coarsening carbides. However, at low temperature, slightly affects diameters roundness carbides exhibit a uniform diameter distribution after prolonging 650°C to 45 min deformation. When content is less than 0.75%, addition...
Abstract We report an oxidative ring‐opening strategy to transform acyl, sulfonyl or carbamate protected aminocyclopropanes into 1,3‐dielectrophilic carbon intermediates bearing a halide atom (Br, I) and N,O‐acetal. Replacing the alkoxy group of N,O‐acetal can be achieved under acidic conditions through elimination–addition pathway, while substitution halides by nucleophiles done basic S N 2 generating wide range 1,3‐difunctionalized propylamines. A proof concept for asymmetric induction was...
In the cation of title hydrated salt, C19H21N2O2S2 (+)·I(-)·H2O, benzo-thia-zolium ring system is approximately planar [maximum deviation = 0.0251 (15) Å], and it makes a small dihedral angle 1.16 (18)° with plane thio-phene ring. crystal, cations, anions crystalline water mol-ecules are linked by classical O-H⋯O, O-H⋯I weak C-H⋯O hydrogn bonds, forming three-dimensional supra-molecular network. π-π stacking observed between parallel thia-zole rings adjacent cations [centroid-centroid...
Abstract Natural wool supported Pd(OAc) 2 ‐complex is found to be an effective catalyst for the C—S bonds cleavage and C—C formation from various disulfides with arylboronic acids or terminal alkynes, giving desired coupling products in high yields.
Abstract Photoactive Cu(I) complexes are promising luminescent materials owing to their abundant reserves and marvelous biocompatibility. In this work, we report the synthesis characterization of two binuclear sulfur‐bridged (POP) 2 Cu (μ‐HS/Cl) ⋅ 0.92MeOH 1 (POP=(oxybis(2,1‐phenylene))bis(diphenylphosphine)) (μ‐HS) , which were prepared by one‐pot facile solvothermal method with copper‐4‐tert‐butylbenzenethiol (CuSC 6 H 4 t Bu) POP as precursors. Complex exhibits sky‐blue emission while...
Luminescent Cu(I) complexes have drawn considerable attention as alternative materials to precious transition metal due their low cost and electron configuration. Discrete heteroleptic diamine-diphosphine copper(I) been investigated owing outstanding photophysical features. However, coordination polymers remain mostly unexplored. Herein, we report the synthesis characterization of a polymer by employing bidentate oxybis(2,1-phenylene)bis(diphenylphosphine) (POP) diphosphine nitrogen...