Opioid use disorder (OUD) presents a serious public health concern, with dramatic increases in opioid-overdose mortality recent years and small percentage of those OUD accessing or remaining engaged available treatments. Efforts are currently underway to identify vaccines targeting opioids, which could provide novel complimentary approach. The current review provides an overview existing literature, practical considerations for designing conducting clinical trials future directions.

Background and Objectives While research on the separate relationships between health‐related quality of life (HRQOL) chronic pain, HRQOL opioid abuse has been sparse, even less work investigated factors associated with in individuals who have both pain meet criteria for use disorder. The data presented this analysis should allow a better understanding important to among dual‐diagnosed population. Methods Individuals dual diagnoses disorder were recruited clinical studies at Columbia...

Medical cannabis research has become quite extensive, with indications ranging from glaucoma to chemotherapy-induced nausea. Despite increased interest in cannabis' potential medical uses, barriers, legislation, stigma, and lack of dissemination data contribute low adoption for some populations. Of interest, use appears palliative care settings, few guidelines available providers. The present study sought examine the attitudes, beliefs, practices providers regarding terminally ill patients....

Background Previous research has identified many genetic polymorphisms that appear to mediate the effects of opioid drugs. However, relationship between and severity withdrawal not yet been characterized. Methods Data were collected from 48 daily heroin users who previously completed a standardized abstinence-induced or naloxone-precipitated procedure assess dependence. The total score (based on COWS) this was correlated with genotype information for variants OPRM1 (rs1799971; rs6848893),...

Drug addiction is a chronic relapsing disorder characterized by compulsive drug seeking and continued use despite negative consequences. Behavioral impulsivity strong predictor of the initiation maintenance addiction. Preclinical data suggest that heroin may exacerbate impulsive characteristics in an individual but this has yet to be assessed clinical samples. The current secondary analysis sought investigate effects on along with exposure cues. Using set, we also tentatively etiological...

Cannabis has been found to alleviate a wide array of medical symptoms, including those that overlap with physical and emotional symptoms premenstrual syndrome (PMS) dysphoric disorder (PMDD), insomnia, irritability, depression, joint pain. Little work addressed the use cannabis as treatment for PMS or PMDD role women's expectancies predictor consumption. Women who reported having experienced endorsed lifetime (N = 145), completed an online survey assessing their frequency use, PMS/PMDD...

Heavy, frequent cannabis use covaries with cannabis-associated problems. With policy changing worldwide, identifying risk factors for problems is crucial. While researchers have consistently studied frequency and quantity of as important risks, clinical lore suggests that the timing might also contribute to Similar morning alcohol among alcohol-dependent individuals, marijuana may indicate dependence increased cannabis-related impairment. Morning has potential lend itself straightforward...

Fentanyl is a highly lipophilic mu opioid receptor agonist, increasingly found in heroin and other drug supplies, that contributing to marked increases opioid-related overdose may be complicating treatment of use disorder (OUD). This study aimed measure the influence body mass index (BMI) on fentanyl withdrawal clearance.This secondary analysis, from 10-day inpatient safety efficacy sublingual dexmedetomidine for withdrawal, includes participants with OUD (n = 150) recruited three sites New...

Background: Endocannabinoids, which are present throughout the central nervous system (CNS), can activate CB1 and CB2 receptors. agonists exhibit broad anti-inflammatory properties, suggesting their potential to treat inflammatory diseases. However, careful evaluation of abuse is necessary. Methods: This study evaluated lenabasum, a selective receptor agonist in participants (n=56) endorsing recreational cannabis use. Three doses lenabasum (20, 60, 120mg) were compared placebo, nabilone (3...

Impulsivity and substance use covary. Smith Anderson's acquired preparedness model proposes that impulsivity predicts through a mediational such expectancies mediate the relation between drug use. The present study seeks to examine positive urgency, an important component of with specific relations behavior, marijuana expectancies, patterns. focused on sample frequent users (n = 3,616) assessed urgency using UPPS-P, Biphasic Marijuana Effects Scale, adapted form Alcohol Scale measure...

Cannabis remains the most frequently used illicit drug in United States. As its legal status has changed, more people have turned to oral administration ("edibles"). 172 individuals who reported an uncomfortable experience with edible cannabis completed online survey. Despite aversive nature of experience, 62.9% sample that was at least somewhat meaningful and majority participants (95.2%) did not report any medical problems. The common non-medical problem going bed early or lying down...

Background: The changing legal landscape for marijuana requires concerted efforts toward minimizing the potential harms related to use of plant. Purpose/Objectives: Identifying buffers against negative consequences in regular users could help researchers fashion prevention that appeal those who are uninterested messages abstinence. Savoring, a positively-focused, mindful approach making most positive experiences, appears overlap with facets treatment have proven successful problem users....

AbstractAbstractBackground: Impulsivity is implicated in the development and maintenance of Cocaine Use Disorder (CUD). Less work has examined impulsivity's role on interest initiating treatment, treatment adherence, or response. No pharmacotherapies are approved for CUD, so efforts to understand bolster effects psychotherapy important guiding refining treatment. The present study impact impulsivity initiation, outcomes individuals with CUD. Methods: Following completion a larger CUD...

In light of New York's recently reinforced strategy to end the AIDS epidemic by expanding testing, treatment, and access pre-exposure prophylaxis (PrEP), we assessed drug use sexual risk behaviors, along with HIV/Hepatitis C virus (HCV) transmission prevention knowledge among non-treatment-seeking adults opioid disorder (OUD) in York City. Over course 18 months, volunteers screening for research studies Opioid Laboratory at State Psychiatric Institute completed a locally developed...

Previous research has demonstrated the ability of non-active smoked cannabis cigarettes to induce subjective effects intoxication (i.e., placebo effect). No studies have been conduced test whether edible forms cannabis, which are associated with a significant delay in onset effect, able effect. In present study, 20 participants were told that they would receive an lollipop containing high dose tetrahydrocannabinol (THC), but instead given control. Measures and mood taken at baseline, 30...