A5101470026- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and disorders
- Pluripotent Stem Cells Research
- Congenital heart defects research
- Drug Transport and Resistance Mechanisms
- Organ Transplantation Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
Tianjin Medical University
2017-2022
Tianjin Institute of Pharmaceutical Research (China)
2017
Background & AimsThe liver has complex interconnecting blood vessel and biliary networks; however, how the vascular network form regulate each other function are not well-understood. We aimed to examine role of Heg in mammalian development functional maintenance.MethodsGlobal (Heg-/-) or endothelial cell (EC)-specific deletion (Lyve1-Cre;Hegfl/fl ) mice were used study vivo liver. Carbon-ink anterograde retrograde injection visualize 3-dimensional patterning portal networks, respectively....
Abstract The aim of the study is to investigate protective effects TY501 against LCA-induced cholestasis in mice and explore potential mechanisms. It was demonstrated that TY501(5, 15 or 45 mg/kg, i.g.) can markedly reduced level ALT, AST ALP which increased by LCA treatment. Meanwhile, also lowered total bile acids, bilirubin cholesterol levels serum. Furthermore, protect HepG2 cell cultures from cytotoxicity. RT-PCR Western Blot analysis showed recovered expression BSEP, MRP2 NTCP were...