A5074797659- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Diabetic Foot Ulcer Assessment and Management
- Acute Kidney Injury Research
- Dysphagia Assessment and Management
- Dietary Effects on Health
- Atrial Fibrillation Management and Outcomes
- Esophageal and GI Pathology
- Frailty in Older Adults
- Heart Failure Treatment and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal Diseases and Glomerulopathies
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Clinical Nutrition and Gastroenterology
- Receptor Mechanisms and Signaling
- Healthcare cost, quality, practices
- Muscle and Compartmental Disorders
Hvidovre Hospital
2021-2024
Copenhagen University Hospital
2021-2024
The Capital Region Pharmacy
2021-2024
University of Copenhagen
2018-2023
Amager Hospital
2021-2023
Universität Hamburg
2022
University Medical Center Hamburg-Eppendorf
2022
German Centre for Cardiovascular Research
2022
Rationale & ObjectiveOlder adults represent nearly half of all hospitalized patients and are vulnerable to inappropriate dosing medications eliminated through the kidneys. However, few studies in this population have evaluated performance equations for estimating glomerular filtration rate (GFR)—particularly those that incorporate multiple markers.Study DesignCross-sectional diagnostic test substudy a randomized clinical trial.Setting ParticipantsAdults ≥ 65 years age presenting emergency...
Malnutrition in older patients is linked to poor appetite. Cannabis-based medicine may have orexigenic properties patients, but this has our knowledge never been investigated. In uncertainty applies the accuracy of estimated glomerular filtration rate (eGFR) based on creatinine, which crucial for medication prescribing. with appetite, study aims (1) assess efficacy Sativex® (8.1-mg delta-9-tetrahydrocannabinol [THC] and 7.5-mg cannabidiol [CBD]) stimulate appetite (2) compare performance...
Diagnosis of acute kidney injury (AKI) based on plasma creatinine often lags behind actual changes in renal function. Here, we investigated early detection AKI using the soluble urokinase plasminogen activator receptor (suPAR) and neutrophil gelatinase-sssociated lipocalin (NGAL) observed impact prescribing recommendations for renally-eliminated medications. This study is a secondary analysis data from DISABLMENT cohort acutely admitted older (≥65 years) medical patients (n = 339). Presence...
Medication deprescribing is essential to prevent inappropriate medication use in multimorbid patients. However, experience of Danish Subacute Medical Outpatient Clinics (SMOCs) limited. The objective our pilot study was evaluate the feasibility and sustainability a collaborative intervention by pharmacist physician patients SMOC. A randomized controlled conducted, with phone follow-up at 30 365+ days. senior performed systematic using Screening Tool Older Persons' potentially Prescriptions...
Internationally, older patients (≥65 years) account for more than 40% of acute admissions. Older admitted to the emergency department (ED) are frequently malnourished and exposed inappropriate medication prescribing, due in part inaccuracy creatinine-based equations estimated glomerular filtration rate (eGFR). The overall aims this trial investigate: (1) efficacy a review (MED intervention) independent nutritional status, (2) accuracy eGFR based on various biomarkers compared measured GFR...
Sympathetic and vagal activation is linked to atrial arrhythmogenesis. Here we investigated the small conductance Ca2+-activated K+ (SK)-channel pore-blocker N-(pyridin-2-yl)-4-(pyridine-2-yl)thiazol-2-amine (ICA) on action potential (AP) fibrillation (AF) parameters in isolated rat atria during β-adrenergic [isoprenaline (ISO)] muscarinic M2 [carbachol (CCh)] activation. Furthermore, antiarrhythmic efficacy of ICA was benchmarked toward class-IC drug flecainide (Fleca). ISO increased...
Background & Aim Malnutrition, risk of malnutrition, and factors for malnutrition are prevalent among acutely admitted medical patients aged ≥65 years have significant health-related consequences. Consequently, we aimed to investigate the effectiveness a multidisciplinary transitional nutritional intervention on quality life compared with standard care. Methods The study was block randomized, observer-blinded clinical trial two parallel arms. Intervention Group offered consisting dietary...
Hospitalized patients are at an increased risk of developing kidney disease after discharge, often despite the absence any clinical indicators during hospitalization. Soluble urokinase plasminogen activator receptor (suPAR) is a marker systemic chronic inflammation that can be measured from routine blood samples. We determined whether elevated suPAR hospitalization associated with decline in estimated glomerular filtration rate (eGFR) discharge. This was retrospective longitudinal cohort...
In human hearts, muscarinic receptors (M-R) are expressed in ventricular and atrial tissue, but the acetylcholine-activated potassium current (IK,ACh) is mainly atrium. M-R activation decreases force increases electrical stability atrium, impact of IK,ACh to both effects remains unclear. We used a new selective blocker elaborate contribution activation-mediated Force action potentials were measured rat atria right trabeculae. Cumulative concentration-effect curves for norepinephrine-induced...
Aims To investigate whether the association between levels of medication use (including polypharmacy and potentially inappropriate medications [PIMs]) health outcomes such as readmission mortality is dependent on baseline soluble urokinase plasminogen activator receptor (suPAR). Methods This registry‐based cohort study included medical patients admitted to emergency department at Copenhagen University Hospital Hvidovre, Denmark. Patients were grouped according their admission suPAR levels:...
The study's aim is to compare current and new equations for estimating glomerular filtration rate (GFR) based on creatinine, cystatin C, β-trace protein (BTP) β2 microglobulin (B2M) among patients undergoing major amputation.This a secondary analysis of data from prospective cohort study investigating nontraumatic lower extremity amputation. Estimated GFR (eGFR) was calculated using creatinine (eGFRcre[2009] eGFRcre[2021]), C (eGFRcys), the combination (eGFRcomb[2012] eGFRcomb[2021]) or...