A5024910770- Free Radicals and Antioxidants
- Circadian rhythm and melatonin
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Aldose Reductase and Taurine
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical Acid Research Studies
- Bioactive Compounds and Antitumor Agents
- Tryptophan and brain disorders
- Synthesis and Reactions of Organic Compounds
- Cannabis and Cannabinoid Research
- Photoreceptor and optogenetics research
- Glutathione Transferases and Polymorphisms
- Antioxidant Activity and Oxidative Stress
- Electrochemical sensors and biosensors
- Microbial Natural Products and Biosynthesis
- Cholinesterase and Neurodegenerative Diseases
- Synthesis of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Electrochemical Analysis and Applications
- Synthesis of Indole Derivatives
- Diet, Metabolism, and Disease
- Polyamine Metabolism and Applications
Ankara University
2015-2024
Universidade do Porto
2013-2015
Erciyes University
2013
Gazi University
2011
Istanbul University
2011
Istanbul University-Cerrahpaşa
2011
Georgia State University
2000
Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi
2000
Yamagata University
2000
Hacettepe University
1998-1999
Melatonin (MLT) is a hormone produced in the brain by pineal gland, from amino acid tryptophan. It also an antioxidant with particular role protection of nuclear and mitochondrial DNA. In recent years, many physiological properties MLT have been described resulting much attention development synthetic compounds possessing indole ring. Sixteen analogue hydrazide/hydrazone derivatives were synthesized vitro activity was investigated. Most showed significantly higher than at 10(-3) M 10(-4)...
The aim of this study was to synthesize and examine possible in vitro antioxidant effects indole-based melatonin analogue compounds. As a part our ongoing nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized their activity investigated by three different assays: evaluating reducing effect against oxidation redox sensitive fluorescent probe, examining protective H2O2-induced membrane lipid peroxidation determining inhibitory on AAPH-induced hemolysis human...
Overproduction of reactive oxygen species results in oxidative stress that can cause fatal damage to vital cell structures. It is known the use antioxidants could be beneficial prevention or delay numerous diseases associated with stress. Melatonin (MLT) as a powerful free-radical scavenger and antioxidant. was found indole ring MLT employed by bioisosteric replacement other aromatic rings. Quinoline derivatives constitute an important class compounds for new drug development. Owing...
Oxidative stress has been implicated in the development of many neurodegenerative diseases and also responsible from aging some cancer types. Indolic compounds are a broad family substances present microorganisms, plants animals. They mainly related to tryptophan metabolism, particular properties that depend on their respective chemical structures. Due free radical scavenger antioxidant indolic derivatives such as indolinic nitroxides melatonin, series 2-phenyl indole were prepared vitro...
Indoles and hydrazone-type compounds constitute an important class of for new drug development in order to discover effective compound against multi-drug-resistant microbial infections.A series indole-3-aldehyde 5-bromoindole-3-aldehyde hydrazide hydrazones was evaluated their vitro antimicrobial activities using the 2-fold serial dilution technique Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Escherichia coli, Bacillus subtilis Candida albicans. The minimum inhibitory...
Increased levels of reactive oxygen species attributed to oxidative stress have been found be responsible for the development some vital diseases such as cardiovascular, neurodegenerative and autoimmune diseases. Recently, it was observed that melatonin is a highly important antioxidant, analogues are under investigation find out improved antioxidant activity. In this study, 14 ‐based analogue indole amino acid N‐protected derivatives were synthesized elucidated spectrometrically. To...
Melatonin (MLT) is a hormone synthesized from the pineal gland. It direct scavenger of free radicals, which related to its capability defend cells oxidative stress. Recently MLT-related compounds are under investigation establish exhibit maximum activity with lowest side effects. In this study 5-chloroindole hydrazide/hydrazone derivatives were 5-chloroindole-3-carboxaldehyde and phenyl hydrazine derivatives. All characterized in vitro antioxidant was investigated against MLT BHT. Most...