A5089246081- Renal Diseases and Glomerulopathies
- Lipid metabolism and biosynthesis
- interferon and immune responses
- Photosynthetic Processes and Mechanisms
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Blood disorders and treatments
- Endoplasmic Reticulum Stress and Disease
- Caveolin-1 and cellular processes
- Mitochondrial Function and Pathology
- Viral Infections and Vectors
- Cytokine Signaling Pathways and Interactions
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- Complement system in diseases
University of Miami
2022-2024
University of Miami Hospital
2022
Significance Statement A signaling molecule that plays a role in the innate immune system, stimulator of IFN genes (STING), is crucial regulator cyclic GMP-AMP synthase (cGAS)-STING pathway. This pathway regulates inflammation and energy homeostasis under conditions obesity, kidney fibrosis, AKI, but its exact pathogenesis glomerular diseases remains unclear. The authors found activation STING wild-type mice sufficient to cause albuminuria podocyte loss, cGAS-STING upregulated with...
OSBPL7 and ER stress comprise a central mechanism in glomerular injury. This study highlights crucial link between deficiency CKD. causes stress, leading to podocyte apoptosis. There is selective effect on lipid homeostasis that affects homeostasis, altering cellular triglyceride but not cholesterol content. The interaction of apoptosis supports reduced autophagy, the main driver OSBPL7-deficient podocytes.
Ito, Marie; Varona Santos, Javier T.; Gurumani, Margaret Z.; Sloan, Alexis J.; Merscher, Sandra M.; Fornoni, Alessia Author Information