A5035762218- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Advanced Memory and Neural Computing
- Neurobiology and Insect Physiology Research
- Neuroscience and Neural Engineering
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Action Observation and Synchronization
- Spaceflight effects on biology
- Aesthetic Perception and Analysis
- Neuroscience and Music Perception
- Eicosanoids and Hypertension Pharmacology
- Optical Imaging and Spectroscopy Techniques
- Zebrafish Biomedical Research Applications
- Neural and Behavioral Psychology Studies
- Microbial Metabolism and Applications
- Circadian rhythm and melatonin
Boehringer Ingelheim (Germany)
2016-2024
Boehringer Ingelheim (Australia)
2018-2024
Boehringer Ingelheim (India)
2017-2024
University Psychiatric Hospital
2024
University of Zurich
2024
Bernstein Center for Computational Neuroscience Berlin
2008-2019
Humboldt-Universität zu Berlin
2008-2015
Scuola Internazionale Superiore di Studi Avanzati
2007-2013
Italian Institute of Technology
2007-2008
UNSW Sydney
2008
Rats and mice palpate objects with their whiskers to generate tactile sensations. This form of active sensing endows the animals capacity for fast accurate texture discrimination. The present work is aimed at understanding nature underlying cortical signals. We recorded neuronal activity from barrel cortex while rats used discriminate between rough smooth textures. On whisker contact either texture, firing rate increased by a factor two ten. Average was significantly higher than textures, we...
Conspecific recognition and discrimination is a vital aspect of social interactions. Genetic manipulations have implicated the CA2 sub-field ventral hippocampus in rodent memory. However, little known about nature hippocampal responses to signals. We characterized CA1 rats while interacting with conspecifics across gap. Many cells showed unusual "social presence responses," i.e., large elevations firing rates, which were contingent on conspecific. Sharp-wave ripple activity was also...
Rodents can robustly distinguish fine differences in texture using their whiskers, a capacity that depends on neuronal activity primary somatosensory “barrel” cortex. Here we explore how was collectively encoded by populations of three to seven clusters simultaneously recorded from barrel cortex while rat performed discrimination task. Each cluster corresponded the single-unit or multiunit at an individual electrode. To learn firing different combines represent texture, computed population...
Little is known about how hippocampal neurons in rodents respond to and represent conspecifics. To address this question, we let rats interact while quantifying neuronal activation patterns with extracellular recordings immediate-early gene (c-Fos) expression. A total of 319 single putative pyramidal was recorded dorsal hippocampus. In sessions multiple stimulus rats, no cell responded differentially individual (N = 267 cells). We did find, however, that the presence other induced a...
Schizophrenia has been linked to hypofrontality (reduced prefrontal activation) and neural disinhibition GABAergic inhibition) within the dorsolateral cortex (dlPFC), as well reversal learning deficits. Interestingly, whilst strongly orbitofrontal cortex, research suggests that primate dlPFC - or its rodent analogue, medial PFC (mPFC) is less important for this process. Nevertheless, we hypothesized mPFC may be required if particularly demanding. Furthermore, even not required, impair...
Abstract Neurons in the lateral hypothalamus expressing neuropeptide Hypocretin, also known as orexin, are critical modulators of arousal stability. However, their role different components construct such attention and decision making is poorly understood. Here we study Hypocretin neuronal circuit dynamics during stop action impulsivity a Go/NoGo task mice. We show that activity correlates with anticipation reward. then assessed causal using optogenetics task. stimulation neurons cue period...
Abstract Accumulating evidence supports parvalbumin expressing inhibitory interneuron (PV IN) dysfunction in the prefrontal cortex as a cause for cognitive impairment associated with schizophrenia (CIAS). PV IN decreased activity is suggested to be culprit many of EEG deficits measured patients, which correlate working memory (WM), flexibility and attention. In last few decades, CIAS has been recognized heavy burden on quality life patients schizophrenia, but little progress made finding new...
Apathy, deficiency of motivation including willingness to exert effort for reward, is a common symptom in many psychiatric and neurological disorders, depression schizophrenia. Despite improved understanding the neurocircuitry neurochemistry underlying normal deficient motivation, there still no approved pharmacological treatment such deficiency. GPR139 an orphan G protein-coupled receptor expressed brain regions which contribute neural circuitry that controls effortful responding typically...
Abstract Signals sent back to the neocortex from hippocampus control long-term storage of memories in 1,2 , but cellular mechanisms underlying this process remain elusive. Here, we show that learning is controlled by specific medial-temporal input neocortical layer 1. To used direct cortical microstimulation detection task allowed precise region be examined and manipulated. Chemogenetically suppressing last stage medial temporal loop, i.e. perirhinal cortex 1, profoundly disrupted early...
Extracellular recordings in medial entorhinal cortex have revealed the existence of spatially-modulated firing patterns, which are thought to contribute a cognitive map external space. Previous work indicated that during exploration novel environments, spiking activity deep layers is much sparser than superficial layers. In present report, we ask whether this laminar profile consequence environmental novelty. We report on large dataset juxtacellularly-recorded neurons (n = 70) whose was...
Cognitive flexibility, the ability to adapt unexpected changes, is critical for healthy environmental and social interactions, thus everyday functioning. In neuropsychiatric diseases, cognitive flexibility often impaired treatment options are lacking. Probabilistic reversal learning (PRL) commonly used measure in rodents humans. PRL tasks, subjects must sample choice and, from probabilistic feedback, find current best which then changes without warning. However, rodents, pharmacological...
Abstract Cognitive flexibility, the capacity to adapt behaviour changes in environment, is impaired a range of brain disorders, including substance use disorder and Parkinson’s disease. Putative neural substrates cognitive flexibility include mesencephalic pathways ventral striatum (VS) dorsomedial (DMS), hypothesised encode learning signals needed maximize rewarded outcomes during decision-making. However, it unclear whether projections dorsal are distinct their contribution flexible...
Abstract Cognitive flexibility, the capacity to adapt behaviour changes in environment, is impaired a range of brain disorders, including schizophrenia and Parkinson's disease. Putative neural substrates cognitive flexibility include mesencephalic pathways ventral striatum (VS) dorsomedial (DMS), hypothesized encode learning signals needed maximize rewarded outcomes during decision‐making. However, it unclear whether projections dorsal are distinct their contribution flexible reward‐related...
<title>Abstract</title> Reward processing dysfunctions e.g., anhedonia, apathy, are common in stress-related neuropsychiatric disorders including depression and schizophrenia, there currently no established therapies. One potential therapeutic approach is restoration of reward anticipation during appetitive behavior, deficits which co-occur with attenuated nucleus accumbens (NAc) activity, possibly due to NAc inhibition mesolimbic dopamine (DA) signaling. Targeting regulation ventral...
95(F = 5.812, P < 0.05).In addition, response bias was significantly reduced after bilateral saccadic eye movements relative to that fixation (F 10.366,P 0.01).Statistically significant interaction effects were not observed between movement conditions and face emotion types. Conclusion:The present study showed enhanced the performance of recognition memory task in patients with schizophrenia.This finding suggests may be used for cognitive rehabilitation schizophrenia.