A5079638153- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Dermatological and Skeletal Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Platelet Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Advanced biosensing and bioanalysis techniques
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Sepsis Diagnosis and Treatment
- Zebrafish Biomedical Research Applications
- Lung Cancer Research Studies
- Hematological disorders and diagnostics
- Blood transfusion and management
- Lymphoma Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Oral and gingival health research
Children's Health Ireland at Crumlin
2022-2024
Royal Hospital for Children
2024
Wellcome/MRC Cambridge Stem Cell Institute
2016
Medical Research Council
2016
University of Cambridge
2014-2016
Despite the frequent use and radiation exposure of computed tomography (CT) scans, there is little information on patterns CT their utility in management pediatric patients with fever neutropenia (FN). We examined contribution either commonly employed pan-CT (multiple anatomical locations) or targeted (single location) scanning to identify possible infectious etiologies this challenging clinical scenario. Procedure Pediatric an underlying malignancy admitted for (temperature ≥ 38.3 °C)...
Infant B-cell acute lymphoblastic leukaemia (B-ALL) is a rare, aggressive entity characterised by KMT2A rearrangements and poor outcomes. One of the unique features KMT2A-rearranged infant ALL that contributes to these outcomes particularly high rate central nervous system (CNS) involvement. There broad lack understanding regarding molecular processes immune environment in CNS ALL. This hinders development targeted therapies for ALL, which increasingly essential given potentially reduced...
<b>Neil Barrett</b> discusses the unusual haematological implications of accidental transfusion from a close relative in high profile case She-Hulk, barriers to future research, and real heroes this
Summary Infants and children with MLL-AF4+ leukemia have an urgent need for more efficient less aggressive therapy. In this study, we studied three microRNAs that are downregulated in B-cell precursor acute lymphoblastic (BCP-ALL): miR-194, miR-99b miR-125a-5p. When overexpressed, all impaired the survival of leukemic blasts maintenance BCP-ALL. We identified microRNA target genes responsible phenotype upregulated BCP-ALL: CA5B, PPP3CA PPP2R5C. Using CRISPR-Cas9 specific inhibitors,...
Click to increase image sizeClick decrease size AcknowledgementsThe authors acknowledge all the staff involved in care of these patients and course families themselves.Disclosure statementNo potential conflict interest was reported by author(s).Data availability statementThe data that support findings this study are available on request from corresponding author, AT. The not publicly due their containing information could compromise privacy research participants.Additional...