A5030507737- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Glioma Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Peripheral Artery Disease Management
- Zebrafish Biomedical Research Applications
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Airway Management and Intubation Techniques
- Mitochondrial Function and Pathology
- Hematopoietic Stem Cell Transplantation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Clinical practice guidelines implementation
- Cancer-related molecular mechanisms research
- Radiopharmaceutical Chemistry and Applications
- CAR-T cell therapy research
- Mosquito-borne diseases and control
- Neonatal Respiratory Health Research
- Malaria Research and Control
- RNA modifications and cancer
- Nosocomial Infections in ICU
MRC Centre for Regenerative Medicine
2021-2024
University of Edinburgh
2021-2024
NHS Lanarkshire
2023
Addenbrooke's Hospital
2013
University of Cambridge
2010
Emory University
2010
Background Environmental enrichment (EE) in laboratory animals improves neurological function and motor/cognitive performance, is proposed as a strategy for treating neurodegenerative diseases. EE has been investigated the R6/2 mouse model of Huntington's disease (HD), where increased social interaction, sensory stimulation, exploration, physical activity improved survival. We have also shown previously that HD patients mice disrupted circadian rhythms, treatment which may improve cognition,...
Ventilation-associated pneumonia (VAP) is the commonest nosocomial infection in intensive care. Implementation of a VAP prevention care bundle proven method to reduce its incidence. The UK recommends maintenance tracheal tube cuff pressure at 20 30 cmH₂O with 4-hourly checks and use tubes subglottic aspiration ports patients admitted for more than 72 h.To evaluate effects type monitoring technique on leakage secretions past cuff.Bench-top study.Laboratory.A model adult trachea simulated was...
Background: Environmental enrichment (EE) in laboratory animals improves neurological function and motor/cognitive performance, is proposed as a strategy for treating neurodegenerative diseases.EE has been investigated the R6/2 mouse model of Huntington's disease (HD), where increased social interaction, sensory stimulation, exploration, physical activity improved survival.We have also shown previously that HD patients mice disrupted circadian rhythms, treatment which may improve cognition,...
Infant B-cell acute lymphoblastic leukaemia (B-ALL) is a rare, aggressive entity characterised by KMT2A rearrangements and poor outcomes. One of the unique features KMT2A-rearranged infant ALL that contributes to these outcomes particularly high rate central nervous system (CNS) involvement. There broad lack understanding regarding molecular processes immune environment in CNS ALL. This hinders development targeted therapies for ALL, which increasingly essential given potentially reduced...
Summary Infants and children with MLL-AF4+ leukemia have an urgent need for more efficient less aggressive therapy. In this study, we studied three microRNAs that are downregulated in B-cell precursor acute lymphoblastic (BCP-ALL): miR-194, miR-99b miR-125a-5p. When overexpressed, all impaired the survival of leukemic blasts maintenance BCP-ALL. We identified microRNA target genes responsible phenotype upregulated BCP-ALL: CA5B, PPP3CA PPP2R5C. Using CRISPR-Cas9 specific inhibitors,...
One of the unique clinical features infant leukaemia is a high rate central nervous system (CNS) disease, typically leukaemic infiltrate meninges. Using fully murine MLL-AF4+ model (Malouf et al. Blood 2021), which develops this characteristic meninges, we performed RNA sequencing to identify niche-specific drivers CNS leukaemia. Differential gene expression analysis BM and CNS-derived identified genes involved in PI3K/Akt signalling pathway specifically Pten Cdkn1a. We confirmed these...
Abstract Aim This audit aims to assess the current adherence local health board guidelines for Venous Thromboembolism (VTE) risk assessment in Orthopaedic Trauma lists. Method Data was collected all patients who underwent operation on trauma lists between 1st June 2022 and 31st 2022. included type, if VTE completed admission pre-operatively. Plan post-operatively discharge also noted as well length of prophylaxis prescribed. Results There were 172 total, 117 lower limb procedures 55 upper...
MLL-AF4+ infant leukemia patients have a unique microRNA expression signature that can be used to understand leukemogenesis and identify novel therapeutic avenues. We previously shown miR-128a miR-130b, which are upregulated in patients, act as essential lineage-specific co-drivers of (PMID: 34111240). Our most recent unpublished work now focuses on three additional microRNAs downregulated pro-B ALL patients: miR-194, miR-99b miR-125a-5p. The overexpression all decreased the survival...