A5012849156- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Ocular Infections and Treatments
- Biosensors and Analytical Detection
- TiO2 Photocatalysis and Solar Cells
- Dental Research and COVID-19
- SARS-CoV-2 detection and testing
- Advanced Photocatalysis Techniques
- Algal biology and biofuel production
- Essential Oils and Antimicrobial Activity
- Chemical Synthesis and Reactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- Organic Chemistry Cycloaddition Reactions
- Advanced Chemical Sensor Technologies
- Oil Spill Detection and Mitigation
- Advanced Nanomaterials in Catalysis
- bioluminescence and chemiluminescence research
- Aquaculture disease management and microbiota
- Synthesis and Biological Evaluation
University of Aveiro
2018-2025
Antimicrobial photodynamic therapy (aPDT) is gaining a special importance as an effective approach against multidrug-resistant strains responsible of fatal infections. The addition potassium iodide (KI), non-toxic salt, recognized to increase the aPDT efficiency some photosensitizers (PSs) on broad-spectrum microorganisms. As reported cases only refer positive potentiation results, in this work we selected broad range porphyrinic and non-porphyrinic PSs order gain more comprehensive...
The increasing world-wide rate of antibiotic resistance as well the capacity microorganisms to form biofilms, have led a higher incidence mortal infections that require alternative methods for their control. Antimicrobial photodynamic therapy (aPDT) emerged an effective solution against resistant strains. present work aims evaluate aPDT efficiency photosensitizer (PS) based on low-cost formulation constituted by five cationic porphyrins (FORM) and its potentiation effect KI broad spectrum...
Antimicrobial photodynamic treatment (aPDT) offers an alternative option for combating microbial pathogens, and in this way, addressing the challenges of growing antimicrobial resistance. In promising effective approach, cationic porphyrins related macrocycles have emerged as leading photosensitizers (PS) aPDT. general, their preparation occurs via
The last two years have been marked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This virus is found in intestinal tract; it reaches wastewater systems and, consequently, natural receiving water bodies. As such, inefficiently treated (WW) can be a means of contamination. currently used methods for disinfection WW lead to formation toxic compounds and expensive or inefficient. new alternative approaches must considered, namely, photodynamic inactivation (PDI)....
Abstract Fish is a highly nutritious but perishable food, prone to rapid spoilage due microbial proliferation and biochemical degradation during handling storage. Moreover, certain microorganisms can be pathogenic humans, leading foodborne diseases. This study presents, for the first time, efficacy of photodynamic inactivation (PDI) mediated by 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP) methylene blue (MB) decontaminating seabass ( Dicentrarchus labrax ) fillets. The...
Antibacterial resistance causes around 1.27 million deaths annually the globe and has been recognized as a top 3 priority health threat. Antimicrobial photodynamic therapy (aPDT) is considered promising alternative to conventional antibiotic treatments. Algal lipid extracts have shown antibacterial effects when used photosensitizers (PSs) in aPDT. In this work we assessed efficiency of lipidic microalgae belonging different phyla (Bacillariophyta, Chlorophyta, Cyanobacteria, Haptophyta,...
Research has demonstrated the presence of viruses in wastewater (WW), which can remain viable for a long period, posing potential health risks. Conventional WW treatment methods involving UV light, chlorine and ozone efficiently reduce microbial concentrations, however, they produce hazardous byproducts resistance that are detrimental to human ecosystem. Hence, there is need novel disinfection techniques. Antimicrobial Photodynamic Inactivation (PDI) emerges as promising strategy, utilizing...
Sulfonamides are a conventional class of antibiotics that well-suited to combat infections. However, their overuse leads antimicrobial resistance. Porphyrins and analogs have demonstrated excellent photosensitizing properties been used as agents photoinactivate microorganisms, including multiresistant Staphylococcus aureus (MRSA) strains. It is well recognized the combination different therapeutic might improve biological outcome. In this present work, novel meso-arylporphyrin its Zn(II)...
Antimicrobial resistance remains an enduring global health issue, manifested when microorganisms, such as bacteria, lack responsiveness to antimicrobial treatments. Photodynamic inactivation (PDI) of microorganisms arises a noninvasive, nontoxic, and repeatable alternative for the broad range pathogens. So, this study reports synthesis, structural characterization, photophysical properties new tetra-β-substituted pyridinium-pyrazolyl zinc(II) phthalocyanine (ZnPc
In the present work possibility of improving solubility, bioavailability and bactericidal activity carbon monoxide releasing molecule (CORM) [Mo(CO)5Br]− (as its tetraethylammonium salt) (1) by solvent-free co-grinding with β-cyclodextrin (βCD) in a planetary ball mill was investigated. Data obtained FT-IR spectroscopy, Raman powder X-ray diffraction thermogravimetric analysis showed that, other than small decrease crystallinity 1, process produced finely dispersed physical mixture...
Antimicrobial photodynamic therapy (aPDT) is a promising approach against multidrug-resistant microorganisms. In this work, we accessed the efficiency of an affordable formulation composed five cationic porphyrins (FORM) and its combined effect with potassium iodide (KI) on large spectrum For purpose, aPDT assays were conducted FORM alone + KI planktonic biofilm forms Gram(+) (Staphylococcus aureus) Gram(−) (Escherichia coli) bacteria yeast Candida albicans. The results obtained indicate...
The past 2 years have been marked by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. This virus is found in intestinal tract and reaches wastewater system, and, consequently, natural receiving water bodies, inappropriate or/and inefficient WW treatment a means of contamination. In present work, we used SARS-CoV-2 model—the phage Phi6—to evaluate its survival under different environmental conditions (pH, temperature, salinity, solar, UV-B irradiation). Then, tested...
Currently, world population faces an episode where bacteria are becoming resistant to antibiotics, and it is crucial find alternatives new molecules fight these microorganisms. Photodynamic inactivation of microorganisms has been pointed out as alternative conventional therapies. This work describes the synthesis benzoporphyrins derivatives bearing triazolyl groups analogues with pyridyl units under Heck coupling conditions. The benzoporphyrin containing were further quaternized iodomethane...