A5101428077- Metabolomics and Mass Spectrometry Studies
- Algal biology and biofuel production
- Mass Spectrometry Techniques and Applications
- Advanced Chemical Sensor Technologies
- Mitochondrial Function and Pathology
- Aquaculture Nutrition and Growth
- Metabolism and Genetic Disorders
- Analytical Chemistry and Chromatography
- Cardiac Ischemia and Reperfusion
- Aquaculture disease management and microbiota
- Nitric Oxide and Endothelin Effects
- Systemic Lupus Erythematosus Research
- Photodynamic Therapy Research Studies
- Peroxisome Proliferator-Activated Receptors
- Enzyme Catalysis and Immobilization
- Martial Arts: Techniques, Psychology, and Education
- Aquatic Ecosystems and Phytoplankton Dynamics
- Multiple Sclerosis Research Studies
- Pesticide and Herbicide Environmental Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sphingolipid Metabolism and Signaling
- Physical Education and Sports Studies
- Physical Education and Gymnastics
- Marine and coastal ecosystems
- Diet and metabolism studies
University of Aveiro
2018-2024
Rede de Química e Tecnologia
2020-2024
Universidade de Santa Cruz do Sul
2022
University of Trás-os-Montes and Alto Douro
2018
The demand for sustainable and environmentally friendly food sources ingredients is increasing, microalgae are promoted as a source of essential bioactive lipids, with high levels omega-3 fatty acids (ω-3 FA), comparable to those fish. However, most FA screening studies on algae scattered or use different methodologies, preventing true comparison its content between microalgae. In this work, we used gas-chromatography mass-spectrometry (GC-MS) characterize the profile seven commercial...
Abstract The disruption of mitochondria‐associated endoplasmic reticulum (ER) membranes (MAMs) plays a relevant role in Alzheimer's disease (AD). MAMs have been implicated neuronal dysfunction and death since it is associated with impairment functions regulated this subcellular domain, including lipid synthesis trafficking, mitochondria dysfunction, ER stress‐induced unfolded protein response (UPR), apoptosis, inflammation. Since play an important metabolism, study we characterized...
Nitrated phospholipids have recently been detected in vitro and vivo associated with beneficial health effects. They were identified quantified biological samples by lipidomics methodologies using liquid chromatography-collision-induced dissociation (CID) tandem mass spectrometry (MS/MS) acquired the linear ion trap spectrometer. Only a few studies used higher-energy collision (HCD)-MS/MS high-resolution Orbitraps to characterize nitrated phosphatidylserines cardiolipins, highlighting marked...
Frying allows cooking food while promoting their organoleptic properties, imparting crunchiness and flavor. The drawback is the oxidation of triacylglycerides (TAGs), leading to formation primary oxidized TAGs. Although they have been associated with chronic degenerative diseases, are precursors pleasant flavors in fried foods. Nevertheless, there a lack knowledge about species present foods involvement positive/negative health effects. In this work, high-resolution (HR) C30 reversed-phase...
Nitrated lipids have been detected in vitro and vivo, usually associated with a protective effect. While nitrated fatty acids widely studied, few studies reported the nitration nitroxidation of phospholipid classes phosphatidylcholine, phosphatidylethanolamine. However, no information regarding nitroxidized phosphatidylserine can be found literature. This work aims to identify characterize derivatives 1-palmitoyl-2-oleoyl-sn-3-glycero-phosphoserine (POPS), obtained after incubation nitronium...
is a green microalga extensively explored for β-carotene production, while knowledge of its lipid composition still limited and poorly investigated. Among lipids, polar lipids have been highlighted as bioactive phytochemicals with health-promoting properties. This research aimed to provide an in-depth lipidome profiling
Acute myocardial infarction (AMI) is the leading cause of death, morbidity, and health costs worldwide. In AMI, a sudden blockage blood flow causes ischemia cell death. Reperfusion after has paradoxical effects may exacerbate injury, process known as ischemic reperfusion injury. this work we evaluated lipidome isolated rat hearts, maintained in controlled perfusion (CT), undergoing global (ISC) or followed by (IR). 153 polar lipid levels were significantly different between conditions. 48...
Phosphatidylinositols (PIs) are complex lipids that play a key role in cell signaling. Like other phospholipids, they esterified with unsaturated fatty acyl residues (FAs), making them susceptible to modification by reactive oxygen and nitrogen species (RNS). Recent studies using mass spectrometry (MS)-based lipidomics approaches have revealed lipid nitration results plethora of structurally chemically modified (epilipids), including nitrated nitroxidized derivatives phosphatidylcholines,...
Microbially enriched food in conjugated linoleic (CLA) and linolenic (CLNA) acids is intensively studied nowadays. The conversion of (LA) α-linolenic (α-LNA) into these compounds may involve different fatty acid (FA) intermediates. This research aimed to investigate potential FA byproducts milk during microbial CLA/CLNA-enrichment using Bifidobacterium breve DSM 20091. Milk fermented with pure α-LNA showed a decrease free myristic acid, while LA led an increase stearic acid. No additional...
SETD7 (SET7/9, KMT7) is a lysine methyltransferase that targets master regulators of cell proliferation and differentiation. Here, the impact inhibiting catalytic activity on mammary epithelial differentiation was studied by focusing genes associated with differentiation, lactogenesis, lipid metabolism in HC11 EpH4 lines. Setd7 mRNA protein levels were induced upon lactogenic both Inhibition compound (R)-PFI-2 increased downregulated E-cadherin, beta-catenin, lactoferrin, insulin-like growth...