A5015666553- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Ion channel regulation and function
- Insect symbiosis and bacterial influences
- Protein Structure and Dynamics
- Mathematical and Theoretical Epidemiology and Ecology Models
- Systemic Lupus Erythematosus Research
- Insect and Pesticide Research
- Mosquito-borne diseases and control
- Cardiac electrophysiology and arrhythmias
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
North Carolina State University
2022-2024
Duke University
2020
Duke University Hospital
2020
Duke Medical Center
2020
University of Maryland, Baltimore County
2016
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV during pregnancy leads to a higher frequency (cCMV) than maternal re-infection, suggesting that immunity confers partial protection. However, poorly understood immune correlates protection against placental transmission contributes current lack an approved vaccine prevent cCMV. In this study, we characterized kinetics plasma rhesus (RhCMV) viral load (VL) RhCMV-specific antibody...
Uncovering the sanctuaries of long-lived HIV-1 reservoir is crucial to develop cure strategies. Pediatric immunity distinct from that adults, which may alter where established in infancy. Thus, it important utilize pediatric models inform cure-directed approaches for HIV-1-infected children. We used an infant rhesus macaque model infection via breastfeeding identify key sites viral persistence under antiretroviral therapy (ART). The gastrointestinal tract was found be a site low-level...
Dengue virus, primarily transmitted by the Aedes aegypti mosquito, is a major public health concern affecting ≈3.83 billion people worldwide. Recent releases of Wolbachia-transinfected Ae. in several cities worldwide have shown that it can reduce dengue transmission. However, these are costly, and, to date, no framework has been proposed for determining economically optimal release strategies account both costs associated with disease risk and releases.
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV during pregnancy leads to a higher frequency (cCMV) than maternal re-infection, suggesting that immunity confers partial protection. However, poorly understood immune correlates protection against placental transmission contributes current lack an approved vaccine prevent cCMV. In this study, we characterized kinetics plasma rhesus (RhCMV) viral load (VL) RhCMV-specific antibody...
Similar to observations of HIV-1 decay, the dynamics viral decay following initiation antiretroviral therapy in a nonhuman primate model HIV infection, infant rhesus macaques infected with SHIV.C.CH505, does not follow simple exponential dynamics. Several mathematical models have been proposed describe its more complex behavior, most popular which is two-phase decay. The underlying assumption twophase that there are two classes cells different lifespans. However, excepting CD4+ T cells,...