A5079197869- Neurobiology and Insect Physiology Research
- Insect and Pesticide Research
- Cholinesterase and Neurodegenerative Diseases
- Physiological and biochemical adaptations
- Nanoparticles: synthesis and applications
- Circadian rhythm and melatonin
- Insect and Arachnid Ecology and Behavior
- Vitamin C and Antioxidants Research
- Photodynamic Therapy Research Studies
- Genetics, Aging, and Longevity in Model Organisms
- Plant and animal studies
- Neurotransmitter Receptor Influence on Behavior
- Invertebrate Immune Response Mechanisms
- Animal Behavior and Reproduction
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Phosphodiesterase function and regulation
- Various Chemistry Research Topics
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Zebrafish Biomedical Research Applications
- Neurology and Historical Studies
- Aluminum toxicity and tolerance in plants and animals
- Aquaculture Nutrition and Growth
- RNA modifications and cancer
University of Rijeka
2017-2024
University of Zagreb
2023
Alumosilicate materials zeolites are widely exploited due to porous structure and ion-exchange properties in several industrial, agriculture veterinary applications. The mainly used zeolite for medical purposes animals humans is the natural clinoptilolite. Clinoptilolite may be prepared applications by different methods that usually based on mechanical or tribomechanical processing increase specific surface area. Different procedures known cause substantial changes physical-chemical of...
Reactive Oxidative Species (ROS) are produced during cellular metabolism and their amount is finely regulated because of negative consequences that ROS accumulation has on functioning survival. However, play an important role in maintaining a healthy brain by participating signaling regulating neuronal plasticity, which led to shift our understanding from being solely detrimental having more complex the brain. Here we use Drosophila melanogaster investigate influence behavioral phenotypes...
Drosophila melanogaster can be used to identify genes with novel functional roles in neuronal plasticity induced by repeated consumption of addictive drugs. Behavioral sensitization is a relatively simple behavioral output plastic changes that occur the brain after exposures drugs abuse. The development screening procedures for control has stalled due lack high-throughput tests genetically tractable organism, such as Drosophila. We have developed new test, FlyBong, which combines delivery...
As complexities of addictive behaviors cannot be fully captured in laboratory studies, scientists use simple addiction-associated phenotypes and measure them animals. Locomotor sensitization, characterized by an increased behavioral response to the same dose drug, has been extensively used elucidate genetic basis molecular mechanisms neuronal plasticity. However, what extent it contributes development addiction is not completely clear. We tested if locomotor sensitization methamphetamine...
Addiction is a complex brain disease influenced by genetic, environmental, and neurological factors. Psychostimulants, cocaine, methamphetamine influence different cell types in regions, with focus on the neurons responsible for rewarding effects nucleus accumbens (NAc) ventral tegmental area (VTA). Known markers psychostimulant-induced neuronal plasticity combination droplet-based high-throughput single-cell sequencing divided heterogeneity of populations NAc VTA into clusters, where all...
Non-enzymatic glycation and covalent modification of proteins leads to Advanced Glycation End products (AGEs). AGEs are biomarkers aging neurodegenerative disease, can be induced by impaired neuronal signaling. The objective this study was investigate if manipulation dopamine (DA) in vitro using the model protein, bovine serum albumin (BSA), vivo organism Drosophila melanogaster, influences fluorescent (fAGEs) formation as an indicator dopamine-induced oxidation events. DA inhibited...
Addiction is a multifactorial biological and behavioral disorder that studied using animal models, based on simple responses in isolated individuals. A couple of decades ago it was shown Drosophila melanogaster can serve as model organism for behaviors related to alcohol, nicotine cocaine (COC) addiction. Scoring COC-induced large group flies has been technologically challenging, so we have applied local, middle global level network-based analyses study social interaction networks (SINs)...
Porphyrins are frequently employed in photodynamic therapy (PDT), a non-invasive technique primarily utilized to treat subcutaneous cancers, as photosensitizing agents (PAs). The development of new PA with improved tissue selectivity and efficacy is crucial for expanding the application PDT management diverse cancers. We investigated systemic effects 5,10,15,20-tetrakis(
In this work we hypothesize novel anti‐oxidative role for the stable gastric pentadecapeptide BPC 157 and test using a model organism, Drosophila melanogaster. was originally an anti‐ulcer peptide used in trials ulcerative colitis now is treatment of multiple sclerosis where it largely interacts with NO‐system (Curr Pharm Des 2014;20(7):1126–35). also thought to be mediator Robert's cytoprotection rat studies, its endothelium mucosal protection believed related oxidative stress injury To...
Due to similarities in genetics, cellular response, and behavior, Drosophila is used as a model organism addiction research. A well described behavioral response examined flies the induced increase locomotor activity after single dose of volatilized cocaine (vCOC) methamphetamine (vMETH) known sensitivity, escalation repeated dose, sensitization. However, knowledge about how vCOC vMETH affect different neurotransmitter systems over time scarce. We LC-MS/MS systematically examine changes...
Due to similarities in genetics, cellular response, and behavior, Drosophila is used as a model organism addiction research. A well-described behavioral response examined flies the induced increase locomotor activity after single dose of volatilized cocaine (vCOC) methamphetamine (vMETH), sensitivity, escalation repeated dose, sensitization. However, knowledge about how vCOC vMETH affect different neurotransmitter systems over time scarce. We LC-MS/MS systematically examine changes...