A5068556126- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Organ Donation and Transplantation
- Cancer, Stress, Anesthesia, and Immune Response
- Colorectal Cancer Screening and Detection
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Eicosanoids and Hypertension Pharmacology
- Hippo pathway signaling and YAP/TAZ
- Dialysis and Renal Disease Management
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Ischemia and Reperfusion
- Renal and related cancers
- Cancer Cells and Metastasis
Nanchang University
2021-2025
Second Affiliated Hospital of Nanchang University
2021-2025
Nanjing Normal University
2024
Abstract Renal cell carcinoma (RCC) is one of the most common malignancies in urinary system, and clear renal (ccRCC) subtype. MYBL2 has been reported to be overexpressed various tumors associated with poor prognosis patients, but its biological role ccRCC remains unclear. In this study, we investigated mRNA protein expression levels samples evaluated prognostic value using TCGA dataset. vitro functional assays were performed CCK‐8, EdU, colony formation, scratch, transwell assays, as well...
Renal cell carcinoma (RCC) seriously threatens people's lives and health. The identification of some precise biomarkers during the process RCC progression pathophysiologic procedure is critical for improving diagnosis management RCC. Evidence suggests that ferroptosis may play a pivotal role in eradicating clear (ccRCC, KIRC) tumor cells. We screened out target prognostic ferroptosis-associated genes examined functions farnesyl-diphosphate farnesyltransferase (FDFT1) 786-O cells by plasmid...
Ectodermal neural cortex 1 (ENC1) is a protein that plays crucial role in the regulation of various cellular processes such as cell proliferation, differentiation, and apoptosis. Numerous studies have shown ENC1 overexpressed types cancers, including breast, lung, pancreatic, colorectal cancer, its upregulation correlated with poorer prognosis. In addition to cancer growth spreading, has also been linked neuronal process development crest differentiation. this review, we provide an overview...
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Renal ischemia-reperfusion injury (RIRI) is a common pathological process that causes kidney injury. Previous studies have indicated both peroxisome proliferator-activated receptor γ (PPARγ) and microRNA-21 (miR-21) exert protective effects against RIRI. However, their relationship not well understood. In the present study, we investigated role of PPARγ/miR-21/programmed cell death 4 (PDCD4) axis in IRI, vivo vitro. vitro hypoxia/reoxygenation (H/R) RIRI models were established, viability,...
Background: The immune microenvironment profoundly affects tumor prognosis and therapy. present study aimed to reveal potential escape mechanisms construct a novel prognostic signature via systematic bioinformatic analysis of the bladder cancer (BLCA) microenvironment. Patients Methods: transcriptomic data clinicopathological information for patients with BLCA were obtained from Cancer Genome Atlas (TCGA). Consensus clustering based on CIBERSORT ESTIMATE algorithms was performed BLCA, which...
Objective: The aim of this study was to investigate gender differences after renal ischemia-reperfusion injury in mice and the effects androgen receptor (AR) microRNA-21 (miR-21) on apoptosis injury. Methods: Renal model induced by 45 min bilateral artery ischemia reperfusion. BALB/c were randomly divided into groups according different experimental protocols. levels function evaluated serum creatinine blood urea nitrogen. TUNEL staining used analyze pathological changes tissue, western...
Background: Immunotherapy has emerged as an important technique for treating a variety of cancers. The dynamic interplay between tumor cells and invading lymphocytes in the microenvironment is responsible good response to immunotherapy (TME). Pyroptosis, or inflammation-induced cell death, closely linked number However, papillary renal carcinoma (KIRP), association pyroptosis clinical prognosis, immune infiltration, impact remains unknown. Methods: We carefully investigated link growth,...