A5103109148- Genetics, Aging, and Longevity in Model Organisms
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- Aquaculture disease management and microbiota
- Ion Transport and Channel Regulation
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Aquaculture Nutrition and Growth
- Spaceflight effects on biology
- MicroRNA in disease regulation
Southwest University
2024-2025
Huazhong University of Science and Technology
2015-2023
Institut de Génomique Fonctionnelle
2020-2023
Inserm
2020-2023
Université de Montpellier
2020-2023
Centre National de la Recherche Scientifique
2020-2023
Allosteric modulators bear great potential to fine-tune neurotransmitter action. Promising targets are metabotropic glutamate (mGlu) receptors, which associated with numerous brain diseases. Orthosteric and allosteric ligands act in synergy control the activity of these multidomain dimeric GPCRs. Here, we analyzed effect such molecules on concerted conformational changes full-length mGlu2 at single-molecule level. We first established FRET sensors through genetic code expansion combined...
Significance G protein-coupled receptors regulate several physiological processes, many of which sense nutrients. The mode action these nutrients remains elusive, as it is difficult to control nutrient concentrations around living cells. calcium-sensing receptor regulated by multiple factors, including ions and amino acids, calcium homeostasis; genetic mutations are responsible for human diseases. Here, we investigated this in a perfect ambient Based on the identification ion activation...
Abstract The nervous system plays an important but poorly understood role in modulating longevity. GABA, a prominent inhibitory neurotransmitter, is best known to regulate function and behaviour diverse organisms. Whether GABA signalling affects aging, however, has not been explored. Here we examined mutants lacking each of the major neurotransmitters C. elegans , find that deficiency extends lifespan. This pro-longevity effect mediated by metabotropic B receptor GBB-1, ionotropic A...
This study was the first report regarding application of barley malt (BM) for diets aquaculture species. Triplicate groups grass carp Ctenopharyngodon idellus with an initial size about 1.2 kg were selected and fed either BM or commercial feed (CF) to apparent satiation 8 weeks in outdoor ponds connected a flow-through system. The results showed that final body weight (1651 g) lower fish than CF (1791 g). edible part as indicated by viscerosomatic index. Except ash levels, which fillet fish,...
The eyeless C. elegans exhibits robust phototaxis behavior in response to short-wavelength light, particularly UV light. senses light through LITE-1, a unique photoreceptor protein that belongs the invertebrate taste receptor family. However, it remains unclear how LITE-1 is regulated. Here, we performed forward genetic screen for genes when mutated suppress function. One group of lite-1 suppressors are required producing two primary antioxidants thioredoxin and glutathione, suggesting...
The aim of this study was to explain the mechanism underlying liver injury juvenile largemouth bass
Abstract Selective allosteric modulators bear great potential to fine-tune neurotransmitter-induced brain receptor responses. Promising targets are metabotropic glutamate (mGlu) receptors, which associated different diseases. These multidomain class C GPCRs experience concerted structural rearrangements and rely on modulation of agonist action be fully activated. Here we establish live cell compatible fluorescence labeling mGlu2 by click chemistry through genetic code expansion. Using...