A5020827912- Carbohydrate Chemistry and Synthesis
- Research on Leishmaniasis Studies
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
University of Otago
2022-2025
University of Auckland
2025
This work describes a highly efficient route to an orthogonally protected α-galactosylphytosphingosine (α-GalPhyt) from which 6″-N-modified α-galactosylceramide (α-GalCer) analogues can be synthesized rapidly and on-scale. Key this is the use of d-galactal-derived 1,2-anhydro donor that undergoes α-selective glycosylation with sphingoid acceptor. The resulting α-GalPhyt intermediate deprotected, enabling selective manipulation at either C-6″ position galactose ring or C-2 lipid. utility...
An undergraduate laboratory was developed as part of the Drugs for Neglected Diseases initiative's Open Synthesis Network. This activity aimed to develop new compounds efficacious against visceral leishmaniasis. Students successfully synthesized, purified, and characterized ten different benzoxazole amides that were sent biological testing several protozoan parasites. Although all had poor L. donovani, (2, 4, 9) showed moderate T. cruzi, b. rhodesiense, brucei paired with low cell...