A5017181574- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Diet and metabolism studies
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Bone and Joint Diseases
- Ovarian cancer diagnosis and treatment
- Memory and Neural Mechanisms
- Hematological disorders and diagnostics
- Neuroscience and Neuropharmacology Research
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Stress Responses and Cortisol
- Advanced Data Storage Technologies
- Biochemical effects in animals
- Birth, Development, and Health
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Parallel Computing and Optimization Techniques
- CAR-T cell therapy research
- Scientific Computing and Data Management
University of Southern California
2023-2024
Southern California University for Professional Studies
2023
Icahn School of Medicine at Mount Sinai
2015-2018
Combination immune checkpoint blockade has demonstrated promising benefit in lung cancer, but predictors of response to combination therapy are unknown. Using whole-exome sequencing examine non-small-cell cancer (NSCLC) treated with PD-1 plus CTLA-4 blockade, we found that high tumor mutation burden (TMB) predicted improved objective response, durable benefit, and progression-free survival. TMB was independent PD-L1 expression the strongest feature associated efficacy multivariable analysis....
Background Inhibition of programmed death-ligand 1 (PD-L1) with atezolizumab can induce durable clinical benefit (DCB) in patients metastatic urothelial cancers, including complete remissions chemotherapy refractory disease. Although mutation load and PD-L1 immune cell (IC) staining have been associated response, they lack sufficient sensitivity specificity for use. Thus, there is a need to evaluate the peripheral blood environment conduct detailed analyses load, predicted neoantigens,...
Immune checkpoint inhibitors are promising treatments for patients with a variety of malignancies. Toward understanding the determinants response to immune inhibitors, it was previously demonstrated that presence somatic mutations is associated benefit from inhibition. A hypothesis posited neoantigen homology pathogens may in part explain link between and response. To further examine this hypothesis, we reanalyzed cancer exome data obtained our published study 64 melanoma treated CTLA-4...
"Next generation" data acquisition technologies are allowing scientists to collect exponentially more at a lower cost. These trends broadly impacting many scientific fields, including genomics, astronomy, and neuroscience. We can attack the problem caused by exponential growth applying horizontally scalable techniques from current analytics systems accelerate processing pipelines.
Western diet (WD) consumption during early life developmental periods is associated with impaired memory function, particularly for hippocampus (HPC)-dependent processes. We developed an WD rodent model long-lasting HPC dysfunction to investigate the neurobiological mechanisms mediating these effects. Rats received either a cafeteria-style (ad libitum access various high-fat/high-sugar foods; CAF) or standard healthy chow (CTL) juvenile and adolescent stages (postnatal days 26–56)....
Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due increased neoantigen expression. Many chemotherapies including platinum compounds are known be mutagenic, but the impact standard treatment protocols on mutational burden and resulting expression in most human cancers is unknown.
Abstract Immune checkpoint inhibitors are promising treatments for patients with a variety of malignancies. Toward understanding the determinants response to immune inhibitors, it was previously demonstrated that somatic mutation burden is associated benefit and hypothesis posited neoantigen homology pathogens may in part explain link between mutations response. To further examine this hypothesis, we reanalyzed cancer exome data obtained from published study 64 melanoma treated CTLA-4...
Western diet (WD) consumption during development yields long-lasting memory impairments, yet the underlying neurobiological mechanisms remain elusive. Here we developed an early life WD rodent model to evaluate whether dysregulated hippocampus (HPC) acetylcholine (ACh) signaling, a pathology associated with impairment in human dementia, is causally-related WD-induced cognitive impairment. Rats received cafeteria-style (access various high-fat/high-sugar foods; CAF) or healthy chow (CTL)...
Background Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due increased neoantigen expression. Many chemotherapies including platinum compounds are known be mutagenic, but the impact standard treatment protocols on mutational burden and resulting expression in most human cancers is unknown. Methods We sought quantify effect chemotherapy computationally predicted for 12 high...
Abstract Background: Inhibition of programmed death-ligand one (PD-L1) with atezolizumab can induce durable clinical benefit (DCB) in patients metastatic urothelial cancers, including complete remissions chemotherapy refractory disease. Although mutation load and PD-L1 immune cell (IC) staining have been associated response, they lack sufficient sensitivity specificity for use. Thus, there is a need to evaluate the peripheral blood environment conduct detailed analyses load, predicted...
Early life Western diet (WD) consumption leads to impaired memory function, particularly for processes mediated by the hippocampus. However, precise critical developmental window(s) during which WD exposure negatively impacts hippocampal function are unknown. Here, we exposed male and female rats a model involving free access variety of high-fat and/or high-sugar food drink items either early-adolescent period (postnatal days [PN] 26-41; WD-EA) or late-adolescent (PN 41-56; WD-LA). Control...