A5103120014- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Click Chemistry and Applications
- Polydiacetylene-based materials and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Tetrazole Derivatives
- Prion Diseases and Protein Misfolding
- Graphene and Nanomaterials Applications
- Sulfur-Based Synthesis Techniques
- Organophosphorus compounds synthesis
- Protein Structure and Dynamics
- 2D Materials and Applications
- Synthesis and biological activity
- Chemical Synthesis and Reactions
- Alzheimer's disease research and treatments
- Advanced Synthetic Organic Chemistry
- DNA and Nucleic Acid Chemistry
- Chemical Reactions and Isotopes
Tel Aviv University
2019-2020
Indian Institute of Science Bangalore
2016
Bangalore University
2010-2013
Diphenylalanine (FF) represents the simplest peptide building block that self-assembles into ordered nanostructures with interesting physical properties. Among self-assembled structures, FF nanotubes display notable stiffness and piezoelectric parameters (Young's modulus = 19–27 GPa, strain coefficient d33 18 pC/N). Yet, inorganic alternatives remain major materials of choice for many applications due to higher piezoelectricity. Here, aiming broaden motif in chemistry, we designed three...
Peptidomimetic low-molecular-weight hydrogelators, a class of peptide-like molecules with various backbone amide modifications, typically give rise to hydrogels diverse properties and increased stability compared peptide hydrogelators. Here, new peptidomimetic hydrogelator is designed based on the well-studied
The extension of the amyloid hypothesis to include non-protein metabolite assemblies invokes a paradigm for pathology inborn error metabolism disorders. However, direct demonstration assembly amyloid-like structures has so far been provided only in vitro. Here, we established an vivo model adenine self-assembly yeast, which toxicity is associated with intracellular accumulation metabolite. Using strain blocked enzymatic pathway downstream adenine, observed non-linear dose-dependent growth...
The variety and complexity of DNA-based structures make them attractive candidates for nanotechnology, yet insufficient stability mechanical rigidity, compared to polyamide-based molecules, limit their application. Here, we combine the advantages polyamide materials structural patterns inspired by nucleic-acids generate a mechanically rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphology photoluminescent properties. assembly possesses...
Abstract Bacterial type IV pili (T4P) are polymeric protein nanofibers that have diverse biological roles. Their unique physicochemical properties mark them as a candidate biomaterial for various applications, yet difficulties in producing native T4P hinder their utilization. Recent effort to mimic the of metal‐reducing Geobacter sulfurreducens bacterium led design synthetic peptide building blocks, which self‐assemble into T4P‐like nanofibers. Here, it is reported efficiently bind metal...
The synthesis of hydroxamic acids starting from carboxylic employing 1-propanephosphonic acid cyclic anhydride (T3P) activation is described. Application ultrasonication accelerates this conversion. Further, the T3P has also been employed to activate hydroxamates, leading isocyanates via Lossen rearrangement. were trapped with suitable nucleophiles afford corresponding ureas and carbamates.
A novel class of N-Fmoc-protected amino alkyl thiocyanates/selenocyanates has been prepared by thiocyanation/selenocyanation the corresponding iodides. These undergo a facile [2+3]-cycloaddition reaction with sodium azide to afford N-Fmoc S/Se-linked tetrazoles.
Coiled-coil peptides represent the principal building blocks for structure-based design of bionanomaterials. The sequence-structure relationship and precise nanoscale ordering coiled-coil helices originate from knob-into-hole (KIH) packing side chains. helical interface stabilized by KIH interaction is known to have chain lengths ranging 30 1000 residues. Yet shortest peptide required oligomerization through assembly still unknown. Here, we report that atomic resolution a minimal...
Abstract The conformational characteristics of protected homo‐oligomeric Boc‐[β 3 (R)Val] n ‐OMe, = 1, 2, 3, 4, 6, 9, and 12 have been investigated in organic solvents using nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR) absorption spectroscopy circular dichroism (CD) methods. detailed 1 H NMR analysis ‐OMe reveals that the peptide aggregates extensively CDCl , but is disaggregated 20%, (v/v) dimethyl sulfoxide (DMSO) CD OH. Limited assignment N‐terminus NH groups,...
Abstract Artificial photosynthesis serves as a promising approach to exploit inexhaustible sunlight energy by converting it into chemical energy. However, the limited availability of stable systems with precise and coordinated organization both an harvesting catalytic moiety hinders its practical application. Herein, for first time, we demonstrate utilization self‐assembled G‐quadruplex inspired peptide nucleic acid (PNA)‐tetramer (Fmoc‐G‐PNA tetramer) template artificial system. Our...
Novel helical, structures unprecedented in the chemistry of α-polypeptides, may be found polypeptides containing β and γ amino acids. The structural characterization C12 C14 -helices oligo β-peptides was originally achieved using conformationally constrained cyclic β-residues. This study explores conformational characteristics proteinogenic β3 residues homooligomeric sequences addresses issue inducing a transition between helices by introduction guest α-residue. Folded -helical are...
Abstract A convenient procedure is presented for the conversion of aromatic acids and amino into hydroxamates using T3P as activator.
Abstract A facile conversion of N‐Fmoc amino alkyl iodides to the corresponding thiocyanates or selenocyanates is developed.