A5021835886- Malaria Research and Control
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Toxoplasma gondii Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Trypanosoma species research and implications
Oregon Health & Science University
2018-2024
Portland VA Medical Center
2021
Cytochrome bc1 inhibitors have been broadly studied as human and veterinary medicines agricultural fungicides. For the most part, cytochrome compete with ubiquinol at oxidation (Qo) site or ubiquinone quinone reduction (Qi) site. 4(1 H)-Quinolones 3-position substituents may inhibit either based on quinolone ring substituents. that Qi are highly effective against toxoplasmosis, malaria, babesiosis do not bc1. We tested a series of wild-type drug resistant strains Toxoplasma gondii Plasmodium...
The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis its known pharmacodynamic and pharmacokinetic profiles after oral dosing, ELQ-331, prodrug parasite mitochondrial electron transport inhibitor ELQ-300, was selected study pharmacokinetics efficacy as LAI-C in mice. Four trials were conducted which mice injected with single intramuscular dose...
Robenidine is a veterinary drug used in the poultry industry to treat coccidiosis caused by parasites Eimeria genus. Though this compound and related aminoguanidines have recently been studied other pathogens, chemotype has not systematically explored optimize antimalarial activity despite close genetic relationship between Plasmodium (both are members of Apicomplexa phylum unicellular, spore-forming parasites). In study, series aminoguanidine robenidine analogues was prepared tested vitro...
Schistosomiasis caused by Schistosoma spp. is a disease that causes considerable health burden to millions of people worldwide. The limited availability effective drugs on the market and increased risk resistance development due extensive usage, highlight urgent need for new antischistosomal drugs. Recent studies have shown robenidine derivatives, containing an aminoguanidine core, exhibit promising activities against Plasmodium falciparum, motivating further investigation into their...
Abstract Background The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis its known pharmacodynamic and pharmacokinetic profiles after oral dosing, ELQ-331, prodrug parasite mitochondrial electron transport inhibitor ELQ-300, was selected study pharmacokinetics efficacy as LAI-C in mice. Methods Four trials were conducted which mice injected...