A5037480205- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Cardiovascular Health and Disease Prevention
- Moyamoya disease diagnosis and treatment
- Radiation Therapy and Dosimetry
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Renal and Vascular Pathologies
- Nuclear reactor physics and engineering
- Advanced Radiotherapy Techniques
- Fetal and Pediatric Neurological Disorders
- Vascular anomalies and interventions
- Renal function and acid-base balance
- Abdominal Surgery and Complications
- Cell Image Analysis Techniques
- Image Processing Techniques and Applications
- Neurological diseases and metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Congenital Heart Disease Studies
- Pediatric Urology and Nephrology Studies
- Hemispheric Asymmetry in Neuroscience
- Effects of Radiation Exposure
- Veterinary Medicine and Surgery
- Cerebrospinal fluid and hydrocephalus
University Medical Center Utrecht
2019-2025
Spinoza Centre for Neuroimaging
2024
UK Dementia Research Institute
2024
Ludwig-Maximilians-Universität München
2024
German Center for Neurodegenerative Diseases
2024
Synergy Health
2024
University of Edinburgh
2024
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia, but little known about mechanisms at the level vessels. 7T-MRI allows assessing function in vivo different populations. We hypothesized that multiple aspects are altered patients with cSVD these abnormalities relate to burden.
Objective Cerebral small vessel diseases (cSVDs) are a major cause of stroke and dementia. We used cutting‐edge 7T‐MRI techniques in patients with Autosomal Dominant Arteriopathy Subcortical Infarcts Leukoencephalopathy (CADASIL), to establish which aspects cerebral function affected by this monogenic form cSVD. Methods recruited 23 CADASIL (age 51.1 ± 10.1 years, 52% women) 13 age‐ sex‐matched controls (46.1 12.6, 46% women). Small measures included: basal ganglia centrum semiovale...
Proton therapy is becoming increasingly available, so it important to apply objective and individualized patient selection identify those who are expected benefit most from proton compared conventional intensity modulated radiation (IMRT). Comparative treatment planning using normal tissue complication probability (NTCP) evaluation has recently been proposed. This work investigates the impact of NTCP model dose uncertainties on model-based selection.We used IMRT (IMPT) plans 78 oropharyngeal...
Cerebral small vessel diseases (SVDs) are a major cause of stroke and dementia. Yet, specific treatment strategies lacking in part because limited understanding the underlying disease processes. There is therefore an urgent need to study SVDs at their core, vessels themselves. This paper presents rationale design [email protected] study, which aims establish measures cerebral dysfunction on 7T MRI as novel markers SVDs. prospective observational cohort with two years follow-up. recruits...
Cerebral small vessel disease contributes to stroke and cognitive impairment interacts with Alzheimer pathology. Because of the dimensions affected vessels, in vivo characterization blood flow properties is challenging but important unravel underlying mechanisms disease.A 2D phase-contrast sequence at 7T MR imaging was used assess velocity pulsatility index perforating basal ganglia arteries. We included patients cerebral amyloid angiopathy (n = 8; identified through modified Boston...
Sporadic cerebral small vessel disease (SVD) and autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL) share clinical neuroimaging features possibly vascular dysfunction(s). However few studies have included both conditions, assessed more than one dysfunction simultaneously, or centre. The INVESTIGATE-SVDs study will assess several cerebrovascular dysfunctions MRI in participants sporadic SVD CADASIL at three European centres. We recruit SVDs (ischaemic...
Background Damping of heartbeat‐induced pressure pulsations occurs in large arteries such as the aorta and extends to small microcirculation. Since recently, 7 T MRI enables investigation damping cerebral arteries. Purpose To investigate flow pulsatility between first segment middle artery (M1) perforating using magnetic resonance imaging. Study Type Retrospective. Subjects Thirty‐eight participants (45% female) aged above 50 without history heart failure, carotid occlusive disease, or...
Enlarged perivascular spaces (EPVS) are common in cerebral small vessel disease (CSVD) and have been identified as a marker of dysfunctional brain clearance. However, it remains unknown if the enlargement occurs predominantly around arteries or veins. We combined
Background Blood flow velocity and pulsatility of small cerebral perforating arteries can be measured using 7T quantitative 2D phase contrast (PC) MRI. However, ghosting artifacts arising from subject movement pulsating large cause false positives when applying a previously published perforator detection method. Purpose To develop robust, automated method to exclude perforators located in artifacts. Study Type Retrospective. Subjects Fifteen patients with vascular cognitive impairment or...
Cerebral perforating artery flow velocity and pulsatility can be measured using 7 tesla (T) MRI. Enabling these metrics on more widely available 3T systems would make them employable. It is currently unknown whether measurements performed at MRI due to the lower signal-to-noise ratio (SNR). Therefore, aim of this study investigate if in arteries basal ganglia (BG) assess agreement with 7T as reference. Twenty-nine subjects were included, which 14 patients aortic coarctation [median age 29...
Patients with carotid occlusive disease express altered hemodynamics in the post-occlusive vasculature and lesions commonly attributed to cerebral small vessel (SVD). We addressed question if perforating artery flow measures, using a novel 7T MRI technique, are related SVD lesion burden patients disease. 21 were included uni- (18) or bilateral (3) occlusion (64±7 years) 19 controls (65±10 years). Mean velocity pulsatility arteries semi-oval center (CSO) basal ganglia (BG), measured 2D phase...
<b><i>Introduction:</i></b> Cerebral perforating arteries provide blood supply to the deep regions of brain. Recently, it became possible measure flow velocity and pulsatility in these small arteries. It is unknown if vascular risk factors are related measures. <b><i>Methods:</i></b> We measured artery with 2D phase-contrast 7 Tesla MRI at level centrum semiovale (CSO) basal ganglia (BG) seventy participants from Heart Brain Connection study...
One of the two main branches left renal artery was slowly occluded in four dogs. Repeated angiography carried out from 45 to 61 days postoperatively; this made it possible observe development collaterals between normal and constricted artery, i.e. intrarenal renorenal collaterals. These developed predominantly preexisting vessels extraglomerular system vicinity pelvis calyces and, a lesser extent, medullary forating capsular arteries.
_____________________________________________________________________________________________________attention to the radiotherapy planning and delivery elements, careful systematic prospective documentation of tumor normal tissue outcomes.Even if randomised trials are deemed unsuited setting, protocol based approaches in registered phase I/II appropriate enhance standards should probably include audit quality assurance processes, as well realistic stopping rules address unexpected or...
We assessed blood-flow velocity measurements on 7T MRI as a potential disease marker for cerebral small vessel (SVD). Two-dimensional phase-contrast were performed in perforating arteries of the basal ganglia (BG) and white matter centrum semiovale (CSO) patients with sporadic SVD age- sex-matched controls. Pulsatility index (PI) was significantly higher BG, (0.45 [0.41&ndash;0.49] vs. 0.36 [0.30&ndash;0.41] controls) (p=0.02). In CSO, similar number vessels, mean velocity, PI...
Interest in the small vessels' pathology is growing because of its contribution to cognitive impairment (Pantoni et al., 2009) and possible interaction with AD-related (Boyle 2018). CSVD affects vessels (small arteries & veins, arterioles capillaries), including perforating basal ganglia. Because their dimension, vivo analysis blood flow these challenging. We applied an innovative 2D-Flow sequence at 7 Tesla MRI (Bouvy 2016) order assess velocity pulsatility index (PI) 20 patients (mean [SD]...