A5012832327- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Phytoplasmas and Hemiptera pathogens
- Cardiac Ischemia and Reperfusion
- Protein Structure and Dynamics
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Heat shock proteins research
- Protein Degradation and Inhibitors
- Enzyme Structure and Function
- Polyamine Metabolism and Applications
- Parathyroid Disorders and Treatments
- Agriculture and Rural Development Research
- Dialysis and Renal Disease Management
- Histone Deacetylase Inhibitors Research
- Blood Pressure and Hypertension Studies
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Insect Utilization and Effects
- Amino Acid Enzymes and Metabolism
AstraZeneca (United Kingdom)
2024
University of Glasgow
1993-2020
Cancer Research UK Scotland Institute
2013-2018
National Institute for Medical Research
1994
Universidad de Montevideo
1957
The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges. mechanisms driving such are largely unknown. Here, we show enteroendocrine cells in the adult Drosophila intestine respond nutrients by secreting hormone Bursicon α, which signals via its neuronal receptor DLgr2. α/DLgr2 regulate metabolism through a relay leading restriction...
The porcine spasmolytic protein (pSP) is a 106-residue cell growth factor that typifies family of eukaryotic proteins contain at least one copy an approximately 40-amino acid domain known as the trefoil motif. In fact, pSP contains two highly homologous domains. We have determined complete three-dimensional solution structure by using combination two- and 1H NMR spectroscopy distance geometry calculations. relatively elongated molecule, consisting compact globular domains joined via small...
Bursicon is the main regulator of post molting and eclosion processes during arthropod development. The active hormone a heterodimer Burs-α Burs-β. However, adult midguts express to regulate intestinal stem cell niche. Here, we examined potential expression function its heterodimeric partner, Burs-β in midgut. Unexpectedly, our evidence suggests that not significantly expressed burs-β mutants displayed characteristic developmental defects but showed wild type-like midguts, thus uncoupling...
IT IS a well known fact that in myxedema there is hypotonia of the heart (1), uterus (2), alimentary canal (manifested as megaduodenum (3) or megacolon (4, 5)), and gallbladder (6, 7). Evans (8) mentions case myxedematous patient who had difficulty at beginning micturition pollakiuria, whom volumes residual urine ranging from 700 to 1,500 cc. were obtained by catheterization bladder. A similar was observed Escamilla (9). All these manifestations visceral muscles disappear after treatment...
1. Intracellular pH (pHi) and phosphorus metabolites were measured in isolated ferret hearts with 31P nuclear magnetic resonance (NMR). 2. The application of cyanide (to mimic hypoxia) produced a fall the concentration phosphocreatine ([PCr]) rise those inorganic phosphate ([Pi]) sugar phosphates. These accompanied by an intracellular acidosis. 3. If glycolysis was partly inhibited prior exposure to glucose‐free solution then also [ATP]. acidosis similar that observed presence glucose. 4....
p120ctn is a ubiquitously expressed core component of cadherin junctions and essential for vertebrate development. Surprisingly, Drosophila (dp120ctn) dispensable adherens development, which has discouraged researchers from further pursuing the biological role dp120ctn. Here we demonstrate that dp120ctn loss results in increased heat shock sensitivity reduced animal lifespan, are completely rescued by ectopic expression dp120ctn-GFP transgene. Transcriptomic analysis revealed multiple...