A5017483029- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Insect Resistance and Genetics
- Bone fractures and treatments
- Metabolism, Diabetes, and Cancer
- Medical Imaging Techniques and Applications
- Diabetes and associated disorders
- Forest Insect Ecology and Management
- Elasticity and Material Modeling
- Connective tissue disorders research
- Topology Optimization in Engineering
- Analytical Methods in Pharmaceuticals
- Viral Infectious Diseases and Gene Expression in Insects
- Plant Stress Responses and Tolerance
- Pesticide Residue Analysis and Safety
- Parathyroid Disorders and Treatments
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Advanced X-ray and CT Imaging
- Cardiovascular Syncope and Autonomic Disorders
- Bone and Joint Diseases
- Horticultural and Viticultural Research
- ECG Monitoring and Analysis
- Hip disorders and treatments
- Composite Material Mechanics
University of Bern
1990-2024
University of Utah
2023
Pathologic vertebral fractures are a major clinical concern in the management of cancer patients with metastatic spine disease. These direct consequence effect bone metastases on anatomy and structure bone. The goals this study were twofold. First, we evaluated lytic, blastic mixed (both lytic blastic) structure, its material properties, overall strength. Second, tested ability mineral content (BMC) measurements standard FE methodologies to predict strength real bodies.Fifty-seven bodies...
ABSTRACT Type 1 diabetes (T1DM) is associated with an increased fracture risk, specifically at nonvertebral sites. The influence of glycemic control and microvascular disease on skeletal health in long-standing T1DM remains largely unknown. We aimed to assess areal (aBMD) volumetric bone mineral density (vBMD), microarchitecture, turnover, estimated strength patients T1DM, defined as duration ≥25 years. recruited 59 (disease 37.7 ± 9.0 years; age 59.9 9.9 years.; body mass index [BMI] 25.5...
Local mechanical stimuli in the bone microenvironment are essential for homeostasis and adaptation of skeleton, with evidence suggesting that disruption mechanically-driven remodelling process may lead to loss. Longitudinal clinical studies have shown combined use high-resolution peripheral quantitative computed tomography (HR-pQCT) micro-finite element analysis can be used measure load-driven vivo; however, markers mechanoregulation precision these analyses methods not been validated human...
Recent applications of high-resolution peripheral quantitative computed tomography (HR-pQCT) have demonstrated that changes in local bone remodelling can be quantified vivo using longitudinal three-dimensional image registration. However, certain emerging applications, such as fracture healing and joint analysis, require larger multi-stack scan regions result stack shift artifacts. These artifacts detrimental to the accurate alignment structure across multiple timepoints. The purpose this...
Micro finite element analysis (μFE) is a widely applied tool in biomedical research for assessing vivo mechanical properties of bone at measurement sites, including the ultra-distal radius and tibia. A approach (hFE) based on homogenized constitutive models trabecular offers an attractive alternative clinical use, as it computationally less expensive than traditional μFE. The respective patient-specific strength estimation are usually standard high-resolution peripheral quantitative CT...
High-resolution peripheral quantitative computed tomography (HR-pQCT) based micro-finite element (μFE) analysis allows accurate prediction of stiffness and ultimate load standardised (~1 cm) distal radius tibia sections. An alternative homogenized finite method (hFE) was recently validated to compute the larger (~2 sections that include Colles' fracture sites. Since mechanical integrity weight-bearing is gaining clinical interest, it has been shown same properties can be used predict...
Abstract: Cassida rubiginosa Muell. (Col., Chrysomelidae) is considered to be a native biocontrol agent of the creeping thistle, Cirsium arvense (L.) Scop, one world's worst weeds. However, predation major mortality factor in C. populations and prevents high beetle densities nature. We determined temperature‐dependent detection periods shield remains within predators by immunological gut analysis, order define time period which must have occurred. conducted feeding trials with model Nabis...
HR-pQCT based micro finite element (μFE) analyses are considered as "gold standard" for virtual biomechanical of peripheral bone sites such the distal segment radius and tibia. An attractive alternative clinical use is a homogenized method (hFE) on constitutive models, because its much shorter evaluation times modest computational resource requirements. Such hFE models have been experimentally validated radius, but neither segments tibia nor both measurement together. Accordingly, aim...
Osteogenesis Imperfecta (OI) is an inherited form of bone fragility characterised by impaired synthesis type I collagen, altered trabecular architecture and reduced mass. High resolution peripheral computed tomography (HR-pQCT) a powerful method to investigate morphology at sites including the weight-bearing distal tibia. The resulting 3D reconstructions can be used as basis micro-finite element (FE) or homogenized finite (hFE) models for strength estimation. hFE scheme uses local volume...
The microstructure of trabecular bone is known to adapt its morphology in response mechanical loads for achieving a biomechanical homeostasis. Based on this form-function relationship, previous investigators either simulated the remodeling predict resulting density and architecture specific loading or retraced physiological conditions from local architecture. latter inverse approach includes quantifying using computed tomography calculating relative importance selected load cases by...