A5003149990- Lipid Membrane Structure and Behavior
- Thermodynamic properties of mixtures
- Phase Equilibria and Thermodynamics
- Spectroscopy and Quantum Chemical Studies
- Chemical and Physical Properties in Aqueous Solutions
- Protein Structure and Dynamics
- Chemical Thermodynamics and Molecular Structure
- thermodynamics and calorimetric analyses
- Surfactants and Colloidal Systems
- Advanced Polymer Synthesis and Characterization
- Sphingolipid Metabolism and Signaling
- Spectroscopy and Chemometric Analyses
- Research in Social Sciences
- Analytical Chemistry and Chromatography
- Environmental Chemistry and Analysis
- Process Optimization and Integration
- Proteins in Food Systems
- Ionic liquids properties and applications
- Education, Healthcare and Sociology Research
- Endoplasmic Reticulum Stress and Disease
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pharmacological Effects of Natural Compounds
Tampere University
2008
Helsinki Institute of Physics
2008
International Institute for Applied Systems Analysis
2008
Roskilde University
1999-2005
University of Southern Denmark
2004-2005
Technical University of Denmark
1999-2001
University of Copenhagen
1995-2000
Danmarks Nationalbank
1999
University of British Columbia
1997-1998
We have combined experiments with atomic-scale molecular dynamics simulations to consider the influence of ethanol on a variety lipid membrane properties. first employed isothermal titration calorimetry together solvent-null method study partitioning molecules into saturated and unsaturated systems. The results show that is considerably more favorable in bilayers, which are characterized by their disordered nature compared counterparts. Simulation studies at varying concentrations propose...
Pluronic P85 (poloxamer 235), which is a symmetrical PEO−PPO−PEO triblock copolymer of poly(ethylene oxide) and poly(propylene oxide), has been investigated by differential scanning calorimetry chromatography. Interaction chromatography at critical conditions for PEO was used chromatographic characterization preparative separation according to PPO block lengths. The results show that the sample heterogeneous with respect chemical composition molar mass. contains 12 wt % lower size...
The excess chemical potentials, the partial molar entropies, and volumes in tert-butyl alcohol (TBA)−dimethyl sulfoxide (DMSO)−H2O mixtures were determined. These data, together with previously published enthalpies (Fluid Phase Equilib. 1997, 136, 207) used to evaluate intermolecular interactions. TBA−TBA TBA−DMSO, DMSO−DMSO interactions found be crucially dependent on composition. net interaction terms of potential is very intricate. For example, DMSO a hydrophobic moiety (represented here...
We determined excess chemical potential, partial molar enthalpy, entropy and volume, heat capacity, isothermal compressibility thermal expansivity for aqueous butan-1-ol in the water-rich region up to phase separation boundary at 25°C. The latter three response functions were used calculate mean-square fluctuation densities, which signifies amplitude, or intensity, of fluctuations cross (entropy–volume) fluctuations. Furthermore, we calculated (mean-square) normalized that are indicative...
The molecular mechanisms by which ethanol and other short-chain alcohols perturb biological systems have been suggested to involve specific interactions with proteins and/or nonspecific the lipid bilayer part of membranes. To gain insight into influence on well-defined bilayers, isothermal titration calorimetry (ITC) is used determine excess partial molar enthalpy alcohol in liposome suspensions as well liposomes dilute alcohol−water mixtures at temperatures above main phase transition...
Volume changes associated with the partitioning of eight different alcohols and acetone into unilamellar vesicles dimyristoyl phosphatidylcholine in fluid state was investigated by newly designed, automated titration densitometric equipment. The change free volume process, expressed specific excess solutions, positive for all solutes. magnitude total per mole alcohol partitioned, ΔVm, calculated combining volumetric data previously published coefficients. For aliphatic 1-alcohols, ΔVm...
The conformational stability of calreticulin was investigated. Apparent unfolding temperatures (Tm) increased from 31 degrees C at pH 5 to 51 9, but electrophoretic analysis revealed that oligomerized instead unfolding. Structural analyses showed the single C-terminal alpha-helix major importance calreticulin.