A5079905978- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Syncope and Autonomic Disorders
- Pericarditis and Cardiac Tamponade
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Antimicrobial Resistance in Staphylococcus
- Cardiomyopathy and Myosin Studies
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic Disease and Treatment Approaches
- Analytical Methods in Pharmaceuticals
- Surgical site infection prevention
Université Claude Bernard Lyon 1
1999-2024
Hôpital Louis Pradel
2000-2015
Hospices Civils de Lyon
1995-2013
Intensive Care Society
2006-2013
May Institute
2013
Hôpital Pierre Wertheimer
2013
Lille’s Cardiology Hospital
1991-2012
Hôpital Arnaud de Villeneuve
1997-2008
Inserm
2006-2008
Université Paris Cité
2008
Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury occurs at time reperfusion. In this pilot trial, we sought to determine whether administration cyclosporine percutaneous coronary intervention (PCI) would limit size infarct during acute infarction.We randomly assigned 58 patients who presented with ST-elevation infarction receive either an intravenous bolus 2.5 mg per kilogram body...
Background— We previously demonstrated that ischemic postconditioning decreases creatine kinase release, a surrogate marker for infarct size, in patients with acute myocardial infarction. Our objective was to determine whether could afford (1) persistent size limitation and (2) an improved recovery of contractile function several months after Methods Results— Patients presenting within 6 hours the onset chest pain, suspicion first ST-segment–elevation infarction, whom clinical decision made...
Intravenous thrombolysis remains a widely used treatment for ST-elevation myocardial infarction; however, it carries higher risk of reinfarction than primary PCI (PPCI). There are few data comparing PPCI with followed by routine angiography and PCI. The purpose the present study was to assess contemporary outcomes in infarction patients, specific emphasis on pharmacoinvasive strategy (thrombolysis angiography) PPCI.This nationwide registry France included 223 centers 1714 patients over...
AimsThe CAPTIM (Comparison of primary Angioplasty and Pre-hospital fibrinolysis In acute Myocardial infarction) study found no evidence that a strategy angioplasty was superior in terms 30-day outcomes to pre-hospital with transfer an interventional facility patients managed early at the phase myocardial infarction. The present analysis designed compare both strategies 5 years.
To evaluate the utility of sensory and event-related evoked potentials for prediction awakening/nonawakening in severe anoxic coma to design a decision tree helping any patient this condition.Prospective cohort study.Clinical neurophysiology unit intensive care French university hospital.Sixty-two consecutive comatose patients after out-of-hospital cardiac arrest.None.We gathered clinical variables recorded somatosensory, auditory, cognitive within an average period 8 days arrest. The were...
ST-segment elevation in acute pericarditis is believed to be caused by superficial myocardial inflammation or epicardial injury. We used cardiac troponin I, a sensitive and specific marker of injury, assess lesions idiopathic its relationship elevation.Sixty-nine consecutive patients (53 men, 48+/-17 years) with were included. an enzymoimmunoflurometric method measure serum I on admission (myocardial infarction threshold was 1.5 ng. ml(-1)).Cardiac detectable 34 (49%) beyond the...
Previous reports have shown that radiofrequency ablation can terminate atrial flutter and prevent recurrences. However, different methods been used, the current experience remains limited. The objective of present study was to determine efficacy tissue in patients with using an anatomically guided approach.We treated 22 aged 30 73 years. Atrial recurrent for a mean 5 years despite administration multiple antiarrhythmic drugs. Radiofrequency directed isthmus between inferior vena cava...
To avoid atrioventricular node-His bundle ablation, catheter ablation of the atrial myocardium was attempted in eight patients with drug refractory type I flutter. In seven patients, a zone prolongation and fragmentation endocardial electrogram found low posterior part right atrium. Entrainment flutter by high pacing accompanied local recording second-degree regional block several sectors but never septal area. We, therefore, hypothesized that latter represented critical slow conduction...
To determine factors predictive of mortality in patients undergoing emergency mitral valve surgery the setting severe post-infarction regurgitation.Patients admitted for an acute myocardial infarction who required urgent regurgitation were studied. Factors outcome analysed.Fifty-five consecutive (mean 65+/-10 years, 37 males) included. The infarct was inferior 31 patients, posterior 10, anterior 9 and lateral 5. Thirty-four (62%) Killip class IV. Peroperative findings confirmed total...
Introduction: The aim of this study was to determine whether impaired adaptation the QT interval changes in heart rate predicts sudden death after an acute myocardial infarction. Methods and Results: Groupe d'Etude du Pronostic de l'Infarctus Myocarde (GREPI) trial a prospective multicenter designed evaluate long‐term outcome dynamicity evaluated 265 patients by analyzing 24‐hour Holter recordings obtained 9 14 days linear regression slope intervals measured apex end T wave (QTe) plotted...
Electrophysiologic studies were performed in three patients suffering from attacks of paroxysmal tachycardia with wide QRS complexes. Two had atrioventricular dissociation. The arrhythmia could be initiated and terminated by premature ventricular stimulation all patients. One patient developed the after rapid atrial stimulation. In each subject, complexes during identical to recorded supraventricular beats (left bundle branch block pattern two cases right one). A His potential was noted...
Patients with an implanted cardioverter defibrillator (ICD) may experience a certain degree of suffering. A sample 32 patients was surveyed to determine the psychological benefit resulting from this treatment.Hamilton Anxiety Scale, Beck Depression Inventory and shortened version Minnesota Multiphasic Personality were used. 10-item scale global index quality life especially designed assess tolerance effect its implantation on patients' current well-being.Both scores negatively correlated...
The effects of amiodarone on the sinuatrial node were studied in 24 patients after an intravenous injection drug (5 mg/kg). Sinuatrial function was assessed by rapid atrial pacing and premature stimulation. Sinus cycle length did not change significantly, but corrected sinus recovery time prolonged. While there no significant conduction time, prolongation non-reset zone 14 cases, as well abolition platesu 2/24 patients, suggested that responses to might have been depressed.
Objectives The present study was performed to evaluate whether the modalities of risk stratification after myocardial infarction were still operative in thrombolytic era. Background Prediction fatal events aftermath relies on tests which aim assess function, residual ischaemia and propensity for ventricular arrhythmias. Recent data improved prognosis have led view that needs be updated. Methods In this multicentre, prospective study, 471 acute patients, 45% whom given therapy, enrolled from...
<i>Objective:</i> Microvascular obstruction (MO) is a factor of adverse outcome in patients with ST-elevated myocardial infarction (STEMI). We assessed the presence and extent MO its relationship infarct size left ventricular (LV) functional parameters after acute non-ST-elevated (NSTEMI). <i>Methods:</i> Twenty-five first NSTEMI underwent cine first-pass perfusion cardiac magnetic resonance (CMR) study, late gadolinium enhancement imaging 72 h infarction....