A5100687043- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Toxin Mechanisms and Immunotoxins
- Phagocytosis and Immune Regulation
- Neuroendocrine Tumor Research Advances
- Cancer, Stress, Anesthesia, and Immune Response
- Chemokine receptors and signaling
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Neuroblastoma Research and Treatments
- Low-power high-performance VLSI design
- Cancer Research and Treatments
- Phytochemistry and Bioactive Compounds
- Medicinal Plant Pharmacodynamics Research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immune cells in cancer
- Chromatin Remodeling and Cancer
- Cancer therapeutics and mechanisms
- Genetic Associations and Epidemiology
- Magnesium in Health and Disease
- Bone and Dental Protein Studies
- Winter Sports Injuries and Performance
- Vector-Borne Animal Diseases
Sichuan University
2023
West China Hospital of Sichuan University
2023
St. Jude Children's Research Hospital
2023
Kelun Group (China)
2022-2023
Union Hospital
2023
Huazhong University of Science and Technology
2023
Shanghai Veterinary Research Institute
2022
Chinese Academy of Agricultural Sciences
2022
Hubei University of Technology
2021
Hangzhou Center for Disease Control and Prevention
2020
Purpose This study aimed to investigate the causal association between unhealthy lifestyle factors and diabetic retinopathy (DR) risk determine better interventions targeting these modifiable factors. Design Two-sample Mendelian randomization (MR) analysis was performed in this study. The inverse variance-weighted method used as primary method. Method Our included 687 single-nucleotide polymorphisms associated with instrumental variables. Aggregated data on individual-level genetic...
Purpose The aim of this study was to improve the intratumoral accumulation an antibody–drug conjugate (ADC) and minimize its off-target toxicity, SKB264, a novel anti-trophoblast antigen 2 (TROP2) ADC that developed using 2-methylsulfonyl pyrimidine as linker payload (KL610023), belotecan-derivative topoisomerase I inhibitor. preclinical pharmacologic profiles SKB264 were assessed in study. Methods vitro vivo including efficacy, pharmacokinetics–pharmacodynamics (PK-PD), safety, tissue...
Bovine herpesvirus type 1 (BHV-1) causes bovine respiratory disease that poses a significant threat to the cattle industry. The prevalence of BHV-1 has recently increased in China. However, lack information about prevalent isolates limits control disease. In this study, novel strain was isolated from nasal swabs Holstein cows 2020 China, designated as BHV SHJS. genome SHJS is 135, 102 bp length and highly similar SP1777 (KM258883.1) with an identity 99.64%. Mutations, insertions, or...
Circular RNAs (circRNAs), a new class of non-coding RNAs, have been recently confirmed to regulate cell development, functions and certain types pathological responses. In addition, it has proved that circ_0000190 can serve as tumor suppressor in several cancers. However, the underlying mechanism biological cervical cancer (CC) remain be revealed. our study, relative expression indicated molecules was detected by RT-qPCR analysis. Loss-of-function gain-of-function experiments were conducted...
Nitrogen-vacancy (NV) center is a kind of point defect, which consist nitrogen atom and vacancy distributed in diamond. Under the irradiation 532nm laser, NV can emit fluorescence with 640nm∼800nm wavelength, while intensity could be influenced by microwave magnetic field. This feature used to realize high-precision field measurement. The current sensor has characteristics ultrahigh precision long-term stability, leads great application potential such as transformers. In test, it was found...
<p>PDF file - 127K, Detailed description of some the routine procedures used to generate data</p>
<p>PDF file - 476KB Supplementary Figure 1. CX3CR1 is expressed in multiple types of ovarian carcinoma. Brown CX3CR1; blue hematoxylin. Images were generated using an Aperio ScanScope digital slide scanner. Magnification 20X. Positive cases Krukenberg tumors (core A7), yolk sac B3), dysgerminoma C4), mature teratomas D3), Sertoli-stromal cell E9), granular F4), thecomas G7), and gynandroblastomas H10) are presented; these detailed Supplemental Table 4.</p>
<p>PDF file - 225K, Immunohistochemical analysis of XCR1 expression in distant metastasis originating from different primary solid tumors: a) bladder to pelvic cavity, b) breast armpit, c) cervix d) colon liver, e) endometrium abdominal f) esophagus mediastinum, g) kidney right upper arm, h) larynx neck, i) liver j) lung cerebellum, k) skin left thigh groin, l) pancreas omentum, m) prostate costal bone, n) duodenum mesentery, o) rectum ovary, p) small intestine q) stomach wall, r)...
<p>PDF file - 21K, Alignment of XCL1 (NM_002995) and XCL2 (NM_003175) gene sequences using NCBI BLAST (NIH). Nucleotides that do not match are highlighted in yellow. Positions the used to construct primers for detection indicated by blue arrows.</p>
<p>Detailed methods, description of supplemental tables, and figures.</p>
<div>Abstract<p>Pediatric sarcomas represent a heterogeneous group of malignancies that exhibit variable response to DNA-damaging chemotherapy. Schlafen family member 11 protein (SLFN11) increases sensitivity replicative stress and has been implicated as potential biomarker predict agents (DDA). SLFN11 expression was quantified in 220 children with solid tumors using IHC. Sensitivity the PARP inhibitor talazoparib (TAL) topoisomerase I irinotecan (IRN) assessed sarcoma cell...
<div>Abstract<p>Pediatric sarcomas represent a heterogeneous group of malignancies that exhibit variable response to DNA-damaging chemotherapy. Schlafen family member 11 protein (SLFN11) increases sensitivity replicative stress and has been implicated as potential biomarker predict agents (DDA). SLFN11 expression was quantified in 220 children with solid tumors using IHC. Sensitivity the PARP inhibitor talazoparib (TAL) topoisomerase I irinotecan (IRN) assessed sarcoma cell...