A5101726981- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Free Radicals and Antioxidants
- Synthesis of β-Lactam Compounds
- Synthesis and Biological Evaluation
- Andrographolide Research and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Animal Virus Infections Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Hibiscus Plant Research Studies
- Click Chemistry and Applications
- Synthesis and pharmacology of benzodiazepine derivatives
- Sesame and Sesamin Research
- Inorganic and Organometallic Chemistry
- Estrogen and related hormone effects
- Viral gastroenteritis research and epidemiology
- Synthesis and Characterization of Pyrroles
- Dye analysis and toxicity
- Advances in Cucurbitaceae Research
- Diverse Scientific Research Studies
- HER2/EGFR in Cancer Research
Nitte University
2012-2025
Career Point University
2023
Lala Lajpat Rai University of Veterinary and Animal Sciences
2019
Christ University
2010
ABSTRACT The most frequent type of breast cancer in women is infiltrating ductal carcinoma, followed by lobular carcinoma and triple‐negative cancer, which account for 10%–15% cases. Since this disease not aggressive its early stages thus does flee with the duct perspective, Epidermal Growth Factor Receptor (EGFR) was chosen relevance stage 0 as a primary target. study aimed to evaluate protective effects 19 flavonoids against cancer. In addition, pharmacokinetics investigations, molecular...
The recent increase in morbidity is primarily due to chronic diseases including Diabetes, Heart disease, Lung cancer, and brain tumours. results for patients can be improved, the financial burden on healthcare system lessened, through early detection prevention of certain disorders. In this study, we built a machine-learning model predicting existence numerous utilising datasets from various sources, Kaggle, Dataworld, UCI repository, that are relevant each intended predict. Following...
Abstract The effect of different smoking processes on the nutritional value and polycyclic aromatic hydrocarbon (PAHs) content Clarias gariepinus Cyprinus carpio has been assessed in this study. After processes, finish products were analyzed to determine quality PAHs content. Different significantly decreased ( p < 0.05) lipids fish. smoked fish with unfiltered Psidium guajava revealed higher lipid contents 14.17 ± 0.15% 14.96 0.05%, respectively, for SNE GSF SE GSF. A significant...
This study focused on molecular docking, dynamic simulation, and in vivo approaches to examine the interactions between citronellal (CT) neurotoxic proteins. In silico studies of CT were performed using proteins involved pathophysiology stroke, such as interleukin-6 (IL-6), interleukin-12 (IL-12), TNF-α, nitric oxide synthase (NOS), determine binding affinity based their interactions. The docking results revealed that, among targets, NOS had a better energy −6.4 Kcal/mol. showed good...
ABSTRACT Breast cancer, a formidable threat to women's health, mainly manifests in the HER2 subtype, affecting approximately one five women. Thus, this study endeavors pioneer novel approaches by exploring efficacy of benzothiazole‐coupled azetidinone derivatives against EGFR. We aimed elucidate their potential employing comprehensive array silico methodologies, including molecular docking, pharmacokinetics profiling, pharmacophore mapping, dynamic simulations, and MMPBSA analysis....
Background: Andrographolide, the primary active constituent in Andrographis extract, exhibits poor aqueous solubility, necessitating a novel formulation strategy for effective dermal delivery. Aim: To formulate and optimise olive oil-infused emulgel from extract. Methods: Various formulations were prepared using different combinations of oil Carbopol 940. The assessed visual inspection, pH, spreading ability, extrudability, viscosity, drug content, vitro release. optimal (AEE 6) was...
An epidermoid carcinoma is a form of non-melanoma skin cancer that originates from the outer layer skin's squamous cells. Previous studies have shown andrographis extract and andrographolide inhibit growth proliferation cells while also inducing cell cycle arrest apoptosis. The objective this study was to improve anticancer efficacy andrographolide-rich by delivering it in nanoemulgel. During formulation emulgels, sonication, homogenization were employed, 22-factorial design used optimize...
The appearance to antimicrobial resistance the agent has become a matter of high concern for health care professionals since last ten years. It will an effort establish new phenylpropenone pyrrolyl; chalcones as improved agent. In this particular series novel substituted pyrrol (AP1-AP5) were synthesized by simple condensation reaction between different aldehydes and 3 acetyl -2,4-dimethyl pyrrole in presence strong ethanolic base yield chalcones. structures final compounds characterized IR,...
The α,β unsaturated ketone 3-(2,4-dimethyl-1H-pyrrol-3-yl)-1-phenylprop-2-en-1-onederivatives were treated with benzene-1,2-diamine to obtain 2-(2,4-dimethyl-1H-pyrrol-3-yl)-4-phenyl-2,3-dihydro-1H-benzo[b][1,4]diazepine derivatives. These synthesized compound characterized by IR, 1H NMR, and mass spectroscopy. molecules evaluated for invitro antimicrobial activity. All compounds, showed potent anti-microbial activity as compare reference drug. In these study the docked Type IIA...
Anti-microbial resistance has emerged as the leading cause of death worldwide with rise multidrug-resistant (MDR) bacteria, need for novel anti-microbials to treat serious illnesses become a great necessity. Hence, in this study, we aimed design and synthesize benzothiazole-coupled azetidinone derivatives (GD1-GD12) antibacterial agents. The synthesized compounds were elucidated by nuclear magnetic resonance, infrared mass spectroscopy. activities these tested against antibiotic-susceptible...
BOHECO DESIRE is an Ayurvedic proprietary medicine formulated in capsule form, recommended for enhancing sexual health, libido, stamina, and energy. Objectives: This study aims to explore the molecular binding interactions of major phytocompounds present with a target protein also understand affinity bioavailability, using advanced computational tools. Methodology: Molecular docking studies were performed ChemDraw 20.1.1. Glide extra precision (XP) scoring tools employed calculate scores....
Drug resistance causes serious difficulties in the routine therapy for curing common microbial infections. Thus it is very essential to develop new antimicrobial agents which can offer alternative treatments. The development of potent and effective utmost importance overcome emerging multidrug strains bacteria fungi. technique involves Knoevenagel reaction between substituted salicylaldehyde ethyl acetoacetate presence piperidine as catalyst give 3-acetyl coumarin. intermediate coumarinyl...
A series of new substituted coumarinyl schiff base (AJS1-AJS6) have been synthesized by condensing 3-acetyl coumarin and aniline in alcohol medium. The intermediate were Knoevenagel reaction between salicylaldehyde ethylacetoacetate presence piperidine as catalyst. structures the final compounds characterized IR, mass 1H NMR spectra. screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli Pseudomonas aeruginosa tube dilution method. Most...
Present study on NDV was carried out at Department of Veterinary Microbiology, LUVAS, Hisar. As we all know that Newcastle disease is also known as Ranikhet in India. Virus causes a worldwide birds e.g. chickens, turkeys, guinea fowl, pheasants and pigeons. Man susceptible suffers from self limiting conjunctivitis. It transmitted by droplet, direct contact, fomites or the ingestion excreted virus its average incubation period 5-6 days but it may vary 2-15 days. In severe outbreaks symptoms...
Comparative study between HI and Indirect ELISA antibody titres in samples for NDV Virus poultry was carried out at Deptt. of Veterinary Microbiology, LUVAS, Hisar. As we all know that Newcastle disease is also known as Ranikhet India. causes a worldwide birds e.g. chickens, turkeys, guinea fowl, pheasants pigeons. The principal aim this to compare with tests the diagnosis virus (NDV) infections causing respiratory problems poultry. However, comparative has been shown test reproducible have...
The present study was designed to estimate the antimicrobial and antioxidant activities of ethanolic aqueous extract Borassus flabellifer fruit, juice, leaves sap. evaluation carried out by various radical scavenging assays activity disk diffusion method. For antibacterial activity, bacterial species such as Escherichia coli Staphylococcus aureus were tested for all extracts. showed moderate when compared standard vitamin C. In both DPPH nitric oxide assay related IC 50 value, fruit...
Vaccinium secundiflorum of the Ericaceae family, a shrub in Madagascar, is used by localities to treat diabetes mellitus. The study's aim was determine binding interactions thirty phytoconstituents with proteins, 4GQQ and 1HD2, assess their antidiabetic antioxidant activities, respectively. In silico approaches Schrödinger software carried molecular docking, pharmacophore modelling reveal features responsible for biological activities. Quinic acid hyperoside are well-interacted...
In order to develop relatively small molecules as pharmacologically active molecules, a series of novel oxazolidinones having benzothiazinen and their derivatives were synthesized, characterized by IR, 1H NMR Mass spectral studies. Various substituted prepared simple reflux in the presence acetonitrile. Treatment these deravatives with methanesulfonyl gives its sulphonates on further treatment sodium azide tri phenyl phosphine acetic anhydride give acetamide derivatives. Further synthesized...
Pyrimidine, a six-membered heteroaromatic molecule, is structural element found in several essential biomolecules, such as thiamine and nucleosides.Its significant biological activity important chemical medicinal chemistry.Traditional methods for synthesizing pyrimidines often use hazardous solvents toxic reagents, which can pose risk to human health the environment.However, many green chemistry have been developed recent years.These safer more sustainable techniques, catalysts,...