A5089082935- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Clusterin in disease pathology
- Autoimmune Bullous Skin Diseases
- Hepatitis C virus research
- Urinary Tract Infections Management
- Ferroptosis and cancer prognosis
- COVID-19 Clinical Research Studies
- Pediatric Urology and Nephrology Studies
- SARS-CoV-2 and COVID-19 Research
- Genetic and Kidney Cyst Diseases
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Iron Metabolism and Disorders
Riga Stradiņš University
2021-2024
Pauls Stradiņš Clinical University Hospital
2021-2024
BACKGROUND:Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods different pathologies are important. Leucine-rich alpha-2-glycoprotein (LRG-1) an innovative biomarker that elevated in cases angiogenesis, inflammation, kidney injury. However, there limited data about role LRG-1 recipients. The aim this study was to evaluate association between serum LRG-1, urine function...
IgA nephropathy (IgAN) is characterised by the production of galactose-deficient IgA1 (GdIgA1) antibodies. As source pathogenic antibodies, B cells are central to IgAN pathogenesis, but cell activation pathways as well potential dysregulated IgA-secretion remain unknown.
Shrunken Pore Syndrome (SPS), defined as a reduced ratio between two estimated filtration rates (based on cystatin C and creatinine) is an increasingly recognized risk factor for long-term mortality. Although some patients with other conditions might be erroneously identified SPS. Our aim was to bring the focus possible pathophysiologic mechanisms influencing in setting of SARS-CoV-2 pneumonia acute kidney injury.A single-centered prospective cohort study conducted investigate biomarkers...
Abstract Background IgA nephropathy (IgAN) is characterised by the production of galactose-deficient IgA1 (Gd-IgA1) antibodies. As source pathogenic antibodies, B cells are central to IgAN pathogenesis, but cell activation pathways as well potential dysregulated IgA-secretion remain unknown. Methods We carried out flow cytometry analysis peripheral blood in patients with and control subjects a focus on IgA-expressing uncover how these could give rise GdIgA1 Results In addition global changes...
Abstract Background and Aims Patients with chronic kidney disease (CKD) are at an increased risk of cognitive dysfunction, which is characterized by deficits in executive functions, memory attention. Previous studies have suggested that albuminuria lower estimated glomerular filtration rate (eGFR) related to mild impairment (MCI) dementia. There no noticed connection between activity presented dysmorphic red blood cells (RBC) count evaluation results. The aim the study was investigate...
Abstract BACKGROUND AND AIMS Leucine-rich alpha-2-glycoprotein (LRG1) is a novel proangiogenic factor involved in the abnormal angiogenesis and renal fibrosis diabetic nephropathy by potentiating endothelial transforming growth factor-beta/activin receptor-like kinase 1 (TGF-β/ALK1) signalling [1]. TGF-β mediates mesangial matrix accumulation culminating development of glomerulosclerosis [2], which also occurs immunoglobulin A (IgAN) patients. Our study aims to evaluate LRG1 as marker cell...
Abstract BACKGROUND AND AIMS The current strategy to fight against the COVID-19 pandemic involves active patient vaccination. Patients with renal and autoimmune diseases are in high risk for severe infection [1]. Therefore they should be prioritized Immunoglobulin A nephropathy (IgAN) is one of most common primary glomerulonephritis triggered by mucous membrane alteration; however, there a discussion about vaccination-caused IgA flare [2]. immunological nature IgAN misleading information...
Abstract Background and Aims Urine sediment microscopy is mostly abandoned by nephrologists nowadays, however it an important diagnostic tool in kidney urinary tract diseases. The aim of this study to emphasize the benefits urine performed a nephrologist. Method A prospective cohort at Pauls Stradins Clinical University Hospital Nephrology center included patients with histologically confirmed diagnosis IgA nephropathy from 1st January 2020 till December 2020. Appropriately collected samples...
Abstract The aim of the study was to determine kidney survival and validate novel international immunoglobulin A nephropathy (IgAN) prediction tool (PT) in Latvian population. Adults with morphologically confirmed IgAN were included. Kidney analysed Kaplan–Meier method. PT-assigned risk compared calculated by Cox regression model. analysis included 95 patients. five-year Q3 24 months. Women had longer median kidney-survival time (> 60 months) than men (58 months). Median participants MEST...