A5049719830- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Clusterin in disease pathology
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Autoimmune Bullous Skin Diseases
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Gout, Hyperuricemia, Uric Acid
- Neurological Complications and Syndromes
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Urinary Tract Infections Management
- Dupuytren's Contracture and Treatments
- Acute Kidney Injury Research
- Urinary and Genital Oncology Studies
- Congenital limb and hand anomalies
- Blood disorders and treatments
- Nuclear Structure and Function
- Bacteriophages and microbial interactions
- Dermatological and Skeletal Disorders
- Innovation Policy and R&D
- Hepatitis Viruses Studies and Epidemiology
Pauls Stradiņš Clinical University Hospital
2016-2024
Riga Stradiņš University
2010-2024
The European Renal Association - Dialysis and Transplant (ERA-EDTA) Registry collects data on kidney replacement therapy (KRT) via national regional renal registries in Europe countries bordering the Mediterranean Sea. This article summarizes 2018 ERA-EDTA Annual Report, describes epidemiology of KRT for failure 34 countries.Individual patient patients undergoing were provided by or aggregated 17 registries. incidence prevalence KRT, transplantation activity survival probabilities these...
This article presents a summary of the 2017 Annual Report European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry describes epidemiology renal replacement therapy (RRT) for end-stage disease (ESRD) in 37 countries.The ERA-EDTA received individual patient data on patients undergoing RRT ESRD from 32 national or regional registries aggregated 21 registries. The incidence prevalence RRT, kidney transplantation activity survival probabilities these were...
BACKGROUND Major adverse cardiovascular (CV) events (MACEs) are the primary cause of morbidity and mortality in kidney transplantation (KT) recipients. The risk for MACEs is impacted by an array traditional transplant-related non-traditional CV factors. AIM To investigate association between potential factors related to KT MACEs, their modification hyperuricemia (HU). METHODS relationship was examined a cohort 545 patients who underwent 2008 2019. mean age at 55.0 years ± 14.2 (range...
IgA nephropathy (IgAN) is characterised by the production of galactose-deficient IgA1 (GdIgA1) antibodies. As source pathogenic antibodies, B cells are central to IgAN pathogenesis, but cell activation pathways as well potential dysregulated IgA-secretion remain unknown.
Peritonitis caused by Staphylococcusaureus is of major importance in peritoneal dialysis (PD) patients due to its great virulence profile and biofilm formation ability. Bacteriophages are a potential tool treat peritonitis resulting from biofilm-associated infections. We screened S. aureus colonization 71 PD the nasal cavity, groin, exit-site regions analyzed clinical outcomes these patients. performed biofilm-formation testing different strains compared isolates one patient detect...
BACKGROUND:Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods different pathologies are important. Leucine-rich alpha-2-glycoprotein (LRG-1) an innovative biomarker that elevated in cases angiogenesis, inflammation, kidney injury. However, there limited data about role LRG-1 recipients. The aim this study was to evaluate association between serum LRG-1, urine function...
Introduction: Latvia faces a challenging shortage of available kidney donors, leading to significant mismatch between demand for transplantation and supply. Although older adult donors require thorough pre-donation workup rule out medical comorbidities, it offers hope potential candidates. Case Presentation: This case study presents the unique scenario an 87-year-old living donor, where individualized decision-making resulted in outstanding outcomes both donor recipient. Conclusions: The...
Background and objectives: In kidney transplant recipients (KTR), hyperuricemia (HU) is a commonly-observed phenomenon, due to calcineurin inhibitors reduced graft function. Factors predicting HU, its association with function, remains equivocal. Materials Methods: We conducted retrospective longitudinal study assess factors associated HU in KTR, determine risk measured as glomerular filtration rate (GFR). Moreover, GFR > 60 mL/min/1.73 m2 was considered normal. defined serum uric acid...
Abstract Background IgA nephropathy (IgAN) is characterised by the production of galactose-deficient IgA1 (Gd-IgA1) antibodies. As source pathogenic antibodies, B cells are central to IgAN pathogenesis, but cell activation pathways as well potential dysregulated IgA-secretion remain unknown. Methods We carried out flow cytometry analysis peripheral blood in patients with and control subjects a focus on IgA-expressing uncover how these could give rise GdIgA1 Results In addition global changes...
Abstract Background and Aims Kidney transplantation is a treatment for many patients with end stage renal disease leading to increased quality of life. In last decades results in kidney have been improving, but allograft rejection remains an important clinical problem. Graft biopsy the gold standard assess cause transplant status. This study aimed determine histopathological characteristics, short-term outcomes biopsy-proved graft Latvia. Method this retrospective observational all biopsies...
Abstract Kidney transplantation has become a preferred treatment for many patients with end-stage renal disease, leading to increased quality of life. In recent decades, results in kidney have been improving, but allograft rejection remains an important clinical problem. This retrospective study reviewed all biopsies performed at Pauls Stradiņš Clinical University Hospital from January 2014 December 2022, the aim determine and histopathological characteristics, treatment, short-term outcomes...
A patient undergoing peritoneal dialysis was admitted with acute dialysis-related peritonitis. On the 10th day of intraperitoneal antibacterial therapy, patient's dialysate developed a green color. Gallbladder perforation revealed. The underwent conventional cholecystectomy preserved catheter. There are few cases in medical literature about dialysate. In all them, catheters were removed after cholecystectomy. present case report shows an intact catheter and no further complications.Bilirubin...
Abstract BACKGROUND AND AIMS Pulmonary-renal syndrome (PRS) is characterized by rapidly progressive glomerulonephritis and lung vasculitis. Most common causes of PRS are Goodpasture's disease, antineutrophil cytoplasm antibody (ANCA) associated vasculitis systemic lupus erythematosus; rarely it could be caused cryoglobulinemic ANCA cryoglobulins present in a wide range infectious, inflammatory malignant conditions with or without evidence clinical positivity has been described patients human...
Abstract Background and Aims Patients with chronic kidney disease (CKD) are at an increased risk of cognitive dysfunction, which is characterized by deficits in executive functions, memory attention. Previous studies have suggested that albuminuria lower estimated glomerular filtration rate (eGFR) related to mild impairment (MCI) dementia. There no noticed connection between activity presented dysmorphic red blood cells (RBC) count evaluation results. The aim the study was investigate...
Renal anaemia: the role of haemoglobin control in patients with chronic kidney disease Chronic (CKD) is a significant and prevalent health problem world. Anaemia one most common manifestations CKD. The correction anaemia erythropoietin normalises level improves quality life. Many aspects impact treatment erythropoiesis-stimulating agents on progression CKD remain unresolved disputable. present study retrospective chart review 1654 outpatients data were collected from Centre Nephrology...
Abstract Immunoglobulin A nephropathy (IgAN) is the most common chronic glomerulopathy with variable clinical manifestations. IgAN diagnostics became possible in Latvia 2013. The study aim was to describe manifestations Latvian population by analysing epidemiological, clinical, histological data, and reveal factors that might determine course of disease. retrospective, one-centre included biopsy-proven patients over a five-year period Nephrology Centre at Pauls Stradiņš Clinical University...
Abstract BACKGROUND AND AIMS Leucine-rich alpha-2-glycoprotein (LRG1) is a novel proangiogenic factor involved in the abnormal angiogenesis and renal fibrosis diabetic nephropathy by potentiating endothelial transforming growth factor-beta/activin receptor-like kinase 1 (TGF-β/ALK1) signalling [1]. TGF-β mediates mesangial matrix accumulation culminating development of glomerulosclerosis [2], which also occurs immunoglobulin A (IgAN) patients. Our study aims to evaluate LRG1 as marker cell...
Abstract BACKGROUND AND AIMS The current strategy to fight against the COVID-19 pandemic involves active patient vaccination. Patients with renal and autoimmune diseases are in high risk for severe infection [1]. Therefore they should be prioritized Immunoglobulin A nephropathy (IgAN) is one of most common primary glomerulonephritis triggered by mucous membrane alteration; however, there a discussion about vaccination-caused IgA flare [2]. immunological nature IgAN misleading information...