A5010192922- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Catalytic C–H Functionalization Methods
- Estrogen and related hormone effects
- Sulfur-Based Synthesis Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Eicosanoids and Hypertension Pharmacology
- Click Chemistry and Applications
- Catalytic Cross-Coupling Reactions
- Computational Drug Discovery Methods
- Hormonal Regulation and Hypertension
- Bioactive Compounds and Antitumor Agents
- Diabetes Treatment and Management
- Cytokine Signaling Pathways and Interactions
- Free Radicals and Antioxidants
- Synthesis and Biological Evaluation
- Synthesis of β-Lactam Compounds
- Receptor Mechanisms and Signaling
- Cyclopropane Reaction Mechanisms
- Quinazolinone synthesis and applications
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Adenosine and Purinergic Signaling
- Synthesis and Catalytic Reactions
Islamic Azad University Medical Branch of Tehran
2023-2025
Shahid Beheshti University of Medical Sciences
2019-2023
Islamic Azad University Pharmaceutical Sciences Branch
2023
Abstract: Aromatase, a crucial enzyme assigned for transforming androgen into estrogen, has vital function in the advancement of drug-resistant breast cancers that respond to endocrine treatments. Aromatase (CYP19A1) is monooxygenase from cytochrome P450 family involved conversion androgens estrogens. Breast cancer cells express aromatase activity, indicating tumor may be able produce local estrogen. By inhibiting aromatase, serum estrogen levels decrease, which, turn, hinders...
Sclareol is an organic compound with potential anti-tumor effects against various cancer types. However, its precise molecular mechanism in the suppression of tumor growth has not been fully elucidated. In present study, anti-proliferative and apoptosis-inducing sclareol cyclophosphamide were investigated breast cells involvement JAK/STAT pathway was evaluated. For this purpose, MCF-7 cultured treated concentrations to determine IC50. Cell viability measured by MTT assay apoptosis assessed...
In this study, we synthesized some new derivatives of N ‐(4‐amino‐5‐cyano‐6‐(trichloromethyl)pyridin‐2‐yl)alkyl sulfonamides in the presence a copper catalyst. A one‐pot reaction system was used, and four components participated process. These were sulfonyl azides, terminal alkynes, malononitrile, trichloroacetonitrile. The rate increased by use (I) iodide as catalyst tetrahydrofuran used solvent. We achieved final compounds moderate to good yields. Moreover, converted “NH 2 ” side group...
Abstract Soluble epoxide hydrolase (sEH) inhibitors are effective in reducing blood pressure, inflammation, and pain a number of mammalian disease models. As most classical urea‐based sEH suffer from poor solubility pharmacokinetic properties, the development novel with an improved specification has received great deal attention. In this study, series amide‐based bearing phthalimide ring as secondary pharmacophore (P 2 ) was designed, synthesized, evaluated. Docking results illustrated that...
Multiple lines of evidence indicate that the NF-κB signaling pathway plays a pivotal role in carcinogenesis; activation cancer increases cell proliferation and suppresses apoptosis, both which define tumor mass development. Inhibiting leads to suppression by blocking IKK-α/β enzymes, thus inhibiting its translocation. Furthermore, protecting p65 from acetylation phosphorylation inhibits through active site. Some small molecules are assumed inhibit IκB function separately. This study took one...
Abstract A novel series of 2‐(trichloromethyl)‐1 H ‐ benzo[ d ]imidazole analogs were synthesized via an ultrasonic‐assisted, one‐pot, copper‐catalyzed three‐component reaction the amine‐trichloroacetonitrile adduct and 1, 2‐dihalo benzene at room temperature. Affordable starting materials, simple work‐up method, short time process relatively high yields advantages this modified version Ullmann reaction.
The persistence of HIV mutations and the existence multidrug resistance have produced an opportunity for array innovative anti-HIV medicines with a variety structures that target key enzymes.
: A novel series of thiadiazole compounds was synthesized through the reaction thiosemicarbazone intermediates with 2, 3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The antiplatelet activity evaluated using an aggregation test adenosine diphosphate (ADP) and arachidonic acid (AA) as platelet inducers. Among analogs, compound 3b exhibited most potent inhibition induced by ADP (half maximal inhibitory concentration [IC50] = 39 ± 11 µM). Molecular docking studies revealed hydrogen bonds...
Abstract Soluble epoxide hydrolase (sEH) enzyme has been proposed as a promising target for the treatment of several peripheral inflammatory‐related diseases. The most potent sEH inhibitors are urea or amide‐based which play active‐site transition state mimic and often suffer from poor solubility low bioavailability. Therefore, development novel with improved pharmacokinetic specification is great deal attention. In this study, bearing N′ ‐acetylacetohydrazide/oxadiazole moieties primary (P...
: A novel series of diimino dihydroquinazoline derivatives were synthesized from isocyanides and guanidine analogs in quantitative yields by applying an efficient, inexpensive, one-pot copper-catalyzed intramolecular C-H activation reaction under mild conditions. The structures confirmed on the basis IR, 1 HNMR, 13 C NMR, mass spectral elemental analysis data. protocol offers advantages like short time, simple workup process, high yields, environmentally benign methodology. Interestingly,...
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: An unprecedented copper-catalyzed reaction of acetylene analogs with dialkyl azo dicarboxylate and benzazole via a cross-coupling sequence was reported. A library triazolobenzazole fused ring systems including [1,2,3] triazolo [3,4-b] [1,3] benzothiazole, benzoxazole triazolo[3,4-b][1,3]benzimidazole structures were obtained in moderate to excellent yields under very mild conditions. Structural confirmation the final products became possible using different methods like spectroscopy...