A5062573082- interferon and immune responses
- Cholesterol and Lipid Metabolism
- Effects and risks of endocrine disrupting chemicals
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Carcinogens and Genotoxicity Assessment
City of Hope
2022-2023
Beckman Research Institute
2022-2023
The University of Texas at El Paso
2017-2020
One in 8 women will develop breast cancer their lifetime. Yet, the burden of disease is greater Black women. have a 40% higher mortality rate than White women, and incidence at age 40 younger. While underlying cause this disparity multifactorial, exposure to endocrine disrupting chemicals (EDCs) hair other personal care products has been associated with an increased risk cancer. Parabens are known EDCs that commonly used as preservatives products, disproportionately exposed containing parabens.
There are 8 different human syndromes caused by mutations in the cholesterol synthesis pathway. A subset of these disorders such as Smith-Lemli-Opitz disorder, associated with facial dysmorphia. However, molecular and cellular mechanisms underlying deficits not fully understood, primarily because diverse functions Recent evidence has demonstrated that mutation zebrafish ortholog HMGCR results orofacial clefts. Here we sought to expand upon data, deciphering dependent pathway from independent...
Summary Inborn errors of cholesterol metabolism occur as a result mutations in the synthesis pathway (CSP). Although CSP cause multiple congenital anomaly syndrome, craniofacial abnormalities are hallmark phenotype associated with these disorders. Previous studies have established that mutation zebrafish hmgcs1 gene (Vu57 allele), which encodes first enzyme CSP, causes defects development and abnormal neural crest cell (NCC) differentiation. However, molecular mechanisms by products disrupt...
Abstract Background Inborn errors of cholesterol metabolism occur as a result mutations in the synthesis pathway (CSP). Although CSP cause multiple congenital anomaly syndrome, craniofacial abnormalities are hallmark phenotype associated with these disorders. Previous studies have established that mutation zebrafish hmgcs1 gene (Vu57 allele), which encodes first enzyme CSP, causes defects development and abnormal neural crest cell (NCC) differentiation. However, molecular mechanisms by...
The cholesterol synthesis pathway produces two independent lipid molecules, and isoprenoids, both of which have diverse cellular functions. Mutations that inhibit the result in at least 8 different human syndromes, some are characterized by defects facial development. presence dysmorphia these disorders strongly suggests facilitates appropriate Recently, it was demonstrated mutation or inhibition this zebrafish results craniofacial abnormalities interfering with neural crest cell...
Abstract One in 8 women will develop breast cancer their lifetime. Yet, the burden of disease is greater Black women. have a 40% higher mortality rate compared to White women, and incidence at age 40 younger. While underlying cause this disparity multifactorial, exposure endocrine disrupting chemicals (EDCs) hair other personal care products has been associated with an increased risk cancer. Parabens are known EDCs that commonly used as preservatives products, disproportionately exposed...