Tirsit Ketsela Zeleke

ORCID: 0000-0003-3528-0703
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Medication Adherence and Compliance
  • Pharmaceutical Practices and Patient Outcomes
  • Bipolar Disorder and Treatment
  • Health Systems, Economic Evaluations, Quality of Life
  • Diabetes Management and Research
  • Pneumonia and Respiratory Infections
  • Schizophrenia research and treatment
  • Global Maternal and Child Health
  • Blood Pressure and Hypertension Studies
  • Antibiotic Use and Resistance
  • Quality and Safety in Healthcare
  • Liver Disease and Transplantation
  • Disaster Management and Resilience
  • Pharmaceutical studies and practices
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Pharmaceutical Economics and Policy
  • Plant Toxicity and Pharmacological Properties
  • Ethnobotanical and Medicinal Plants Studies
  • Health and Conflict Studies
  • Liver Disease Diagnosis and Treatment
  • Artificial Intelligence in Healthcare
  • Health Services Management and Policy
  • Tryptophan and brain disorders
  • Migration, Health and Trauma
  • Bacterial biofilms and quorum sensing

Debre Markos University
2021-2025

While pharmacotherapy is the primary approach for treating patients with bipolar disorder, non-adherence most common barrier preventing these from achieving optimal medication effectiveness. This study aimed to assess and its predictors among disorder in Northwest Ethiopia. A hospital-based cross-sectional was conducted 404 Ethiopia January March 2024. Study participants were enrolled using systematic random sampling. Medication measured Adherence Rating Scale (MARS). Data entered analyzed...

10.1038/s41598-025-85379-3 article EN cc-by-nc-nd Scientific Reports 2025-01-07

Providing timely first-aid by trained responders can reduce deaths and disabilities from road traffic accidents, a leading global cause of death. Ethiopia ranks 19th worldwide 4th in Africa. Therefore, this study assesses the knowledge and, attitudes toward emergency first aid, its factors among public transport drivers Injibara, Ethiopia. To assess Knowledge, Attitude towards utilization associated Public Transport Service Drivers Northwest Ethiopia, 2023. A cross-sectional was conducted...

10.1186/s12873-025-01190-3 article EN cc-by-nc-nd BMC Emergency Medicine 2025-02-26

Background: An edible oil factory is a labor-intensive and technologically complex industry, with workers potentially exposed to variety of dangers associated such industries. Personal protective equipment universal, legal requirement, an important strategy for preventing occupational injuries illnesses caused by workplace hazards. However, industries receive little attention, especially in Ethiopia. Objective: To assess personal utilization its factors among the PhiBela Burie, Ethiopia,...

10.1177/11786302251321230 article EN cc-by-nc Environmental Health Insights 2025-01-01

Background The incidence and nature of excessive weight gain associated with antiretroviral treatment using tenofovir, lamivudine, dolutegravir based regimens among patients living human immunodeficiency virus has not been properly examined in Ethiopia. Therefore, this study aimed to assess the factors People on a real-world setting. Method A multicenter retrospective cross-sectional was conducted from December 1, 2022, August 30, 2023, involving 620 initiating regimen. Data...

10.3389/fphar.2025.1394458 article EN cc-by Frontiers in Pharmacology 2025-04-04

BackgroundNephrotoxic drugs may hasten the decline in kidney function and worsen progression of renal impairment as a result; these should be avoided or used with caution patients pre-existing insufficiency. The purpose this study was to assess burden nephrotoxic medication use its predictors among underlying impairment.MethodsA multicenter, institution-based, cross-sectional conducted from May 30, 2021 July 2021, at medical wards. Renal impaired admitted during data collection period who...

10.1016/j.heliyon.2024.e24618 article EN cc-by-nc-nd Heliyon 2024-01-01

Antibiotics are drugs of natural or synthetic origin used to treat various infections. The practice excessive and inappropriate antibiotics use is the main global cause bacterial resistance, which one most serious public health threats. It estimated that about 50% antibiotic prescriptions inappropriate. This study assesses prevalence pattern amongst ambulatory care visits in Ethiopia.

10.7573/dic.2023-12-2 article EN Drugs in Context 2024-05-07

Background: Psychotropic medications, consisting of antidepressants, mood stabilizers, antipsychotics, and anxiolytics, are the pillars managing mental illnesses. Since there is impairment in judgment, attitude, stability patients with severe conditions, they vulnerable to non-adherence, which compromises treatment outcome. Nevertheless, a lack studies investigating medication non-adherence its predictors illnesses Ethiopia has been noticed. The purpose this study was evaluate extent...

10.2147/ppa.s422659 article EN cc-by-nc Patient Preference and Adherence 2023-11-01

Background. Kidney disease affects absorption, distribution, metabolism, and excretion of medicines their metabolites. Therefore, when prescribing for patients with kidney disease, dose adjustment is an accepted standard practice. Objective. This study aimed to assess medicine practice associated factors among adult renal impairment admitted medical wards at Amhara region referral hospitals. Method. Multicenter, institution-based, cross-sectional was conducted from March 28, 2020, August 30,...

10.1155/2021/8238250 article EN cc-by International Journal of Nephrology 2021-12-01

Introduction Irrational prescribing and dispensing of oral dosage forms medicines to paediatric patients are major public health issues, especially in low-income middle-income countries. Many challenges affect the rational use children; these include a lack appropriate for age dose flexibility forms. Objectives To assess practices children at dispensaries University Gondar Comprehensive Specialised Hospital (UoGCSH). Method A retrospective design indicators cross-sectional study were used...

10.1136/bmjpo-2023-002431 article EN cc-by-nc BMJ Paediatrics Open 2024-08-01

Patients with chronic kidney disease frequently face various nutritional and metabolic problems that necessitate the use of multiple medications. This drug can lead to several drug-related including adverse events, hospital admissions, poor medication adherence, harmful interactions, inadequate therapeutic outcomes, death. Despite these challenges, there is a notable lack studies on extent its determinants among patients in Ethiopia. study aims assess magnitude identify vulnerability

10.1186/s12882-024-03773-x article EN cc-by BMC Nephrology 2024-10-07

About 80% of pregnant women use at least one medication during their pregnancy period. Many drugs that are not allowed to be used (from FDA Pregnancy Categories D and X) were used. Irrational these may result in different birth defects, as explained by thalidomide diethylstilbestrol's tragedy. Knowledge drug utilization associated factors affect the pattern is important enhance rational prescribing. But information about prescription patterns among scarce Debre Tabor area generally Ethiopia.

10.1155/2024/5577862 article EN cc-by BioMed Research International 2024-01-01

Abstract Background Compared to the overall population, patients with mental health problems are more likely experience concurrent physical illnesses, poorer outcomes, and mortality. Psychotropic medications, which pillars in management of conditions, associated adverse effects such as weight gain, an increased level glucose, elevated circulating lipid levels, all contribute metabolic disorders. Inadequate monitoring may led suboptimal interventions worsening these conditions. However, there...

10.1186/s12888-024-06266-1 article EN cc-by BMC Psychiatry 2024-11-12

Background: Pathophysiological alterations in liver cirrhosis affect how medications are metabolized and eliminated. Therefore, when prescribing medicines for patients with cirrhosis, appropriate prescription of medication is an accepted standard practice. Since require a complex therapy plan, it necessitates regular reviews utilization. However, no research was conducted Ethiopia. The aim this study to figure out the predictors inappropriate prescriptions pattern cirrhosis. Patients...

10.2147/hmer.s423351 article EN cc-by-nc Hepatic Medicine Evidence and Research 2023-09-01

Low levels of living standards amongst street dwellers worldwide limit their access to conventional healthcare services, resulting in self-medication use for the treatment an illness. Nevertheless, has risks, including adverse drug reactions, increased polypharmacy, resistance, dependence, interactions and incorrect diagnosis. Ethiopia a large street-dwelling community; however, there are no studies conducted assessing dwellers. This study provides insight into predictors Ethiopia.

10.7573/dic.2023-7-2 article EN Drugs in Context 2023-01-11
Coming Soon ...