A5026474844- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Catalysis for Biomass Conversion
- Phytochemical compounds biological activities
- Chemical synthesis and pharmacological studies
- Bioactive Compounds and Antitumor Agents
- Biofuel production and bioconversion
- Advanced Cellulose Research Studies
Fundação Oswaldo Cruz
2021-2025
Instituto Nacional de Metrologia, Qualidade e Tecnologia
2018
Leishmaniasis remains a significant public health problem in Brazil, particularly due to Leishmania (Viannia) braziliensis, which is associated with severe dermatological syndromes. The current treatments are limited by toxicity and uncertain efficacy, highlighting the need for new compounds pharmacological potential. This study investigates chalcones as multitarget binding agents oligopeptidase B (OPB) cysteine proteinase (CPB), critical pathogenic determinants of L. (V.) braziliensis....
Epoxy-α-lapachone (Lap) and Epoxymethyl-lawsone (Law) are oxiranes derived from Lapachol have been shown to be promising drugs for Leishmaniases treatment. Although, it is known the action spectrum of both compounds affect Leishmania spp. multiplication, there gaps in molecular binding details target enzymes related parasite’s physiology. Molecular docking assays simulations were performed using DockThor server predict preferred orientation form stable complexes with key metabolic pathway,...