A5017190390- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Bacterial Infections and Vaccines
- Lipid Membrane Structure and Behavior
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Streptococcal Infections and Treatments
University of Toronto
2016-2024
Nutrient acquisition systems are often crucial for pathogen growth and survival during infection, represent attractive therapeutic targets. Here, we study the protein machinery required heme uptake in opportunistic Acinetobacter baumannii. We show that hemO locus, which includes a gene encoding heme-degrading enzyme, is high-affinity from hemoglobin serum albumin. The locus coding scavenger (HphA), secreted by Slam protein. Furthermore, dependent on TonB-dependent receptor (HphR), important...
Iron acquisition systems are crucial for pathogen growth and survival in iron-limiting host environments. To overcome nutritional immunity, bacterial pathogens evolved to use diverse mechanisms acquire iron. Here, we examine a heme system that utilizes hemophores called hemophilins which also referred as HphAs several Gram-negative bacteria. In this study, report three new HphA structures from
Abstract Iron acquisition systems are crucial for pathogen growth and survival in iron-limiting host environments. To overcome nutritional immunity, bacterial pathogens evolved to use diverse mechanisms acquire iron. Here, we examined a heme system driven by hemophores called HphAs from several Gram-negative bacteria. Structural determination of revealed N-terminal clamp-like domain that binds C-terminal eight-stranded β-barrel shares the same architecture as Slam-dependent Neisserial...