A5066839620- Systemic Sclerosis and Related Diseases
- Autoimmune Bullous Skin Diseases
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Connective Tissue Growth Factor Research
- Urticaria and Related Conditions
- Bacterial Identification and Susceptibility Testing
- Mast cells and histamine
- Ocular Surface and Contact Lens
- Kruppel-like factors research
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Pediatric Urology and Nephrology Studies
- Psoriasis: Treatment and Pathogenesis
- Musculoskeletal synovial abnormalities and treatments
- Reproductive Health and Contraception
- Fungal Biology and Applications
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Cell Adhesion Molecules Research
- Reproductive tract infections research
- Drug-Induced Adverse Reactions
- Pressure Ulcer Prevention and Management
- Antifungal resistance and susceptibility
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Hanoi Medical University
2019-2025
National Hospital of Pediatrics
2022-2025
Thai Binh University of Medicine and Pharmacy
2024
University of Fukui
2016-2021
Ministry of Health
2007
Purpose: Staphylococcus aureus is a commensal bacteria species that can cause various illnesses, from mild skin infections to severe diseases, such as bacteremia. The distribution and antimicrobial resistance (AMR) pattern of S. varies by population, time, geographic location, hospital wards. In this study, we elucidated the epidemiology AMR patterns isolated general in Vietnam. Methods: This was cross-sectional study. Data on all 2014 2021 were collected Microbiology department Military...
In a Vietnamese teaching hospital, this study examined the prevalence and patterns of antimicrobial resistance (AMR) common bacteria isolated from hospitalized patients with urinary tract infections (UTIs) between 2014 2021. From 4060 urine samples collected, pathogens were using quantitative culture on brilliance UTI Clarity agar blood agar. Bacterial identification, susceptibility testing, multidrug (MDR) classification followed standardized techniques. Bacteria frequency less than 2%...
Transforming growth factor-β (TGF-β)/Smad signaling is well known to play a critical role in the pathogenesis of systemic sclerosis (SSc). We previously developed an artificial molecule, histidine-pyridine-histidine ligand derivative HPH-15, which may have antifibrotic effect. The purpose present study was clarify effects this drug human skin fibroblasts and preclinical model SSc. HPH-15 on expression extracellular matrix components TGF-β dermal were analyzed. properties its mechanisms also...
Abstract Background Systemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays central role in extracellular matrix (ECM) production by α-SMA-positive myofibroblasts. Myofibroblasts may be partially derived from various precursor cells addition to resident fibroblasts. Recently, our high-throughput vitro screening discovered small compound, LG283, disrupt...
Objective To assess the preclinical efficacy and mechanism of action an anti‐ CX 3 CL 1 monoclonal antibody ( mA b) in systemic sclerosis SS c). Methods Cultured human dermal fibroblasts were used to evaluate direct effect b on fibroblasts. In addition, bleomycin‐induced growth factor–induced models c investigate leukocyte infiltration, collagen deposition, vascular damage skin. Results Anti‐ treatment significantly inhibited Smad3 phosphorylation P < 0.05) expression type I fibronectin...
At a teaching Hospital in Vietnam, the persistently high incidence of diagnosed wound infection poses ongoing challenges to treatment. This study seeks explore causative agents and their antimicrobial multidrug resistance patterns.
, including methicillin-resistant
Fractures of the long bones in lower limbs are injuries that cause severe to extremely pain, posing risks patient's circulation, respiration, and even life. Pain management for patients with limb bone fractures emergency department is critically important.
prevented the development of protective immunity.In another murine model, immunity was also inhibited by azithromycin. 9Brunham et al 10 observed that while chlamydial sexually transmitted infections in Vancouver decreased substantially over a few years after an azithromycin treatment program began, they estimated annual risk re-infection increased 4.6% thereafter.Personal hygiene and environmental improvements have already eliminated blinding trachoma developed some developing...
Abstract BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous adverse drug reactions. There some immunological genetic factors which believed to be involved in the pathogenesis of SJS/TEN. The treatment SJS/TEN is still controversial several studies showed variable results. AIMS: To evaluate clinically efficacy systemic corticosteroid analyze related cytokines METHODS: This open, pilot uncontrolled study was conducted at National Hospital Dermatology...
Abstract BackgroundSystemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays central role in extracellular matrix (ECM) production by myofibroblasts. Myofibroblasts may be derived from epithelial endothelial precursor cells addition to resident fibroblasts. Recently, our high-throughput vitro screening discovered small compound, LG283, can disrupt differentiation...