A5056874321- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Dermatology and Skin Diseases
- Genital Health and Disease
- Connective Tissue Growth Factor Research
- Urologic and reproductive health conditions
- Calpain Protease Function and Regulation
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Urological Disorders and Treatments
- Urticaria and Related Conditions
- Nail Diseases and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Ocular Surface and Contact Lens
- Eosinophilic Disorders and Syndromes
- Celiac Disease Research and Management
- Skin Diseases and Diabetes
- Dermatological and Skeletal Disorders
- Drug-Induced Adverse Reactions
- Immune Response and Inflammation
- Genetic Associations and Epidemiology
- Allergic Rhinitis and Sensitization
University of Fukui
2017-2024
Kumamoto University
1971
Immune checkpoint inhibitors, such as ipilimumab and nivolumab, reverse the imbalance of antitumor self-tolerance enhance T-cell responses. Currently, nivolumab have a reported therapeutic impact on unresectable or metastatic melanomas; however, they also induce immune-related adverse events (irAEs). Ipilimumab-induced cutaneous irAEs are mostly low grade manageable, although all-grade rash may occur in approximately 45% all patients. We here report case young woman with erythema multiforme...
Abstract Background Systemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays central role in extracellular matrix (ECM) production by α-SMA-positive myofibroblasts. Myofibroblasts may be partially derived from various precursor cells addition to resident fibroblasts. Recently, our high-throughput vitro screening discovered small compound, LG283, disrupt...
Abstract Background Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and inflammation, followed excessive fibrosis of the skin other internal organs, including lungs. CX3CL1 (fractalkine), a chemokine expressed on endothelial cells, supports migration macrophages T cells that express its specific receptor CX3CR1 into targeted tissues. We previously reported anti-CX3CL1 monoclonal antibody (mAb) treatment significantly inhibited transforming growth factor...
Objective To assess the preclinical efficacy and mechanism of action an anti‐ CX 3 CL 1 monoclonal antibody ( mA b) in systemic sclerosis SS c). Methods Cultured human dermal fibroblasts were used to evaluate direct effect b on fibroblasts. In addition, bleomycin‐induced growth factor–induced models c investigate leukocyte infiltration, collagen deposition, vascular damage skin. Results Anti‐ treatment significantly inhibited Smad3 phosphorylation P < 0.05) expression type I fibronectin...
Linear IgA bullous dermatosis (LABD) is a rare autoimmune disorder characterized by linear deposits of at the basement membrane zone(BMZ) and/or circulating anti-BMZ antibodies. Comparing with other immuno-bullous diseases, LABD represents heterogeneous disease entitywith diversity pathogenic autoantibodies to different hemidesmosomal antigens and an association malignancies occasional drug use. We herein present 82-year-old Japanese man LABD, whose indirect immunofluorescence using 1M...
To investigate the clinical course of Japanese patients with early diffuse cutaneous systemic sclerosis (dcSSc) and SSc interstitial lung disease (ILD).We prospectively analyzed features 207 dcSSc (n = 150) limited (lcSSc) ILD 57) in 10 medical centers every year for 7 consecutive years.Mean modified Rodnan total skin thickness score (mRSS) was 18.3 67.4% cohort had ILD. Most started immunosuppressive therapy vasodilators during years (83.4% 87.9%, respectively). Mean value mRSS...
Abstract Growing and sustainable consumption of health‐care products raises a controversial issue underlying the reliability an in vitro diagnostic approach for adverse skin reaction. This report aimed to: (i) discuss causative nature commercial dietary supplement composed natural ingredients, particularly Euglena ‐containing product, suspicious erythema multiforme our exemplified case; (ii) to address assay suitability lymphocyte transformation test ( LTT ) identifying allergic reaction any...
Systemic sclerosis (SSc) is a connective tissue disease that characterized by fibrosis in the skin and internal organs, such as lungs. Activated differentiation of progenitor cells, which are mainly resident fibroblasts, into myofibroblasts considered key mechanism underlying overproduction extracellular matrix resultant SSc. Calpains members Ca
92歳,女性。5年前に左腰部の黒褐色局面から皮膚生検を施行され,脂漏性角化症と診断された。その後,腫瘤は緩徐に増大して出血を伴ってきたため当科を受診した。左腰部に,辺縁に褐色斑を伴う黒褐色局面があり,その内部に紅色腫瘤を認めた。病理組織学的に,紅色腫瘤の部分は有棘細胞癌であり,黒褐色局面の部分はクローン型の脂漏性角化症,褐色斑の部分は日光黒子であった。脂漏性角化症と日光黒子は同一スペクトラム上の疾患であり,自験例は,脂漏性角化症に合併した有棘細胞癌である可能性が高いと考えられた。
Dermatomyositis is an autoimmune inflammatory myopathy with characteristic cutaneous features. Dysphagia secondary to oropharyngeal and oesophageal involvement develops in a part of patients dermatomyositis may affect prognosis. Systemic immunosuppressive therapy usually effective for dysphagia as well lesion myositis. Here, we report 78-year-old man anti-TIF-1γ antibody-positive that presented early gastric carcinoma resistant oral prednisolone tacrolimus therapy. Endoscopic examination...
Abstract We conducted a Japanese GWAS for systemic sclerosis (SSc) comprising 1,428 cases and 112,599 controls, the largest Asian SSc ever, identified three novel signals. The lead SNP in FCGR/FCRL region had strong effect size (OR 2.05, P = 4.9×10 −11 ). complete LD SNP, rs10917688, was found cis-regulatory element part of binding motifs IRF8. IRF8 significant locus European rs10917688 showed an association only presence risk allele Japanese. marked with H3K4me1 primary B cells,...
Abstract Background Systemic sclerosis (SSc) is a connective tissue disease that characterized by fibrosis in the skin and internal organs, such as lungs. Activated differentiation of progenitor cells, which are mainly resident fibroblasts, into myofibroblasts considered key mechanism underlying overproduction extracellular matrix resultant SSc. Calpains members Ca 2+ -dependent cysteine protease family, whose enzymatic activities participate signal transduction remodeling, potentially...