A5025481710- Herpesvirus Infections and Treatments
- RNA regulation and disease
- interferon and immune responses
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- FOXO transcription factor regulation
- Circular RNAs in diseases
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
University of Rijeka
2018-2023
Abstract Since the original publication of sRNAtoolbox in 2015, small RNA research experienced notable advances different directions. New protocols for sequencing have become available to address important issues such as adapter ligation bias, PCR amplification artefacts or include internal controls spike-in sequences. microRNA reference databases were developed with foci, either prioritizing accuracy (low number false positives) completeness negatives). Additionally, other molecules well...
Herpes simplex virus 1 is an important human pathogen that has been intensively studied for many decades. Nevertheless, the molecular mechanisms regulating its establishment, maintenance, and reactivation from latency are poorly understood. Here, we show HSV-1-encoded miR-H2 post-transcriptionally edited in latently infected tissues. Hyperediting of viral miRNAs increases targeting potential these may play role latency. We can target ICP4, essential protein. Interestingly, found no evidence...
Herpes simplex virus 1 (HSV-1) expresses a large number of miRNAs, and their function is still not completely understood. In addition, HSV-1 has been found to deregulate host which adds the complexity regulation efficient replication. this study, we comprehensively addressed deregulation miRNAs by massive-parallel sequencing. We that only expressed from single cluster, miR-183/96/182, are reproducibly deregulated during productive infection. These predicted regulate great potential targets...
Herpes simplex virus 1 (HSV-1) expresses a large number of miRNAs, and their function is still not completely understood. In addition, HSV-1 has been found to deregulate host which adds the complexity regulation efficient replication. this study, we comprehen-sively addressed deregulation miRNAs by massive-parallel sequencing. We that only expressed from single cluster, miR-183/96/182 are reproducibly deregulated dur-ing productive infection. These predicted regulate great potential tar-gets...
Abstract Viruses use miRNAs to enable efficient replication, control host defense mechanisms, and regulate latent infection. Herpes simplex virus 1 (HSV-1) expresses multiple miRNAs, whose functions are largely unknown. The evolutionary conservation of many HSV-1 in the closely related HSV-2 suggests their functional importance. similar other transcripts, can undergo various posttranscriptional modifications that may affect biogenesis, stability targeting. To investigate whether editing...