Lai Gwen Chan

ORCID: 0000-0003-3553-1525
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Research Areas
  • HIV/AIDS Research and Interventions
  • HIV Research and Treatment
  • Stroke Rehabilitation and Recovery
  • Acute Ischemic Stroke Management
  • Migration and Labor Dynamics
  • COVID-19 and Mental Health
  • Employment and Welfare Studies
  • Migration, Health and Trauma
  • HIV-related health complications and treatments
  • Cardiac Health and Mental Health
  • Electroconvulsive Therapy Studies
  • Frailty in Older Adults
  • Health Systems, Economic Evaluations, Quality of Life
  • Healthcare professionals’ stress and burnout
  • Takotsubo Cardiomyopathy and Associated Phenomena
  • Mental Health Treatment and Access
  • Bone health and osteoporosis research
  • Neurological Disorders and Treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Bone and Joint Diseases
  • Obsessive-Compulsive Spectrum Disorders
  • Pharmacological Effects and Toxicity Studies
  • Healthcare Decision-Making and Restraints
  • Psychopathy, Forensic Psychiatry, Sexual Offending
  • Treatment of Major Depression

Tan Tock Seng Hospital
2013-2025

Nanyang Technological University
2023-2025

National University of Singapore
2023

Waikato District Health Board
2021

Christian Health Association of Nigeria
2015

Institute of Mental Health
2008-2013

Changi General Hospital
2005

University of Hong Kong
1996

Duchess of Kent Children's Hospital
1996

Background Low-wage migrant workers are vulnerable to healthcare inequities. We sought identify potential barriers and risk factors for mental health issues in non-domestic Singapore, high-risk subgroups. Methods A cross-sectional, interviewer-administered survey of 433 was conducted at subsidised clinics a foreign worker dormitory from July August 2016. Questions assessed usage patterns, affordability issues, care psychological distress using validated screening scale (Kessler-6). Findings...

10.1136/bmjgh-2016-000213 article EN cc-by-nc BMJ Global Health 2017-03-01

To estimate the prevalence of HIV-associated neurocognitive disorders (HAND) among HIV patients in a multiethnic South Asian population, describe pattern impairment HAND and factors associated with HAND.A cross-sectional survey HIV-positive outpatients inpatients.The sole referral centre for HIV/AIDS treatment Singapore.Inclusion criteria were positive, age between 21 80 years old at least 3 education. Exclusion included concomitant delirium, serious systemic disease or major psychiatric...

10.1136/bmjopen-2011-000662 article EN cc-by-nc BMJ Open 2012-01-01

To investigate the effect of sleep disturbances on functional and social outcomes after mild traumatic brain injury.Outpatient injury clinic in a tertiary trauma center.A total 374 patients were assessed within 3 months followed up every for 1 year.Analysis historical cohort naturalistic clinical setting.At each visit, symptoms concussion psychological distress indices measured with Rivermead Postconcussion Questionnaire, 28-item General Health Head Injury Follow-up respectively. Changes...

10.1097/htr.0000000000000119 article EN Journal of Head Trauma Rehabilitation 2015-05-01

Post-stroke depression and anxiety, collectively known as post-stroke adverse mental outcome (PSAMO) are common sequelae of stroke. About 30% stroke survivors develop about 20% anxiety. Stroke with PSAMO have poorer health outcomes higher mortality greater functional disability. In this study, we aimed to a machine learning (ML) model predict the risk PSAMO. We retrospectively studied 1780 patients who were divided into vs. no groups based on results validated anxiety questionnaires. The...

10.3390/s23187946 article EN cc-by Sensors 2023-09-17

Abstract Background The potential clinical impact of routine proactive detection and early intervention for poststroke depression (PSD) is currently unknown, despite broad evidence the adverse PSD on stroke outcomes. Objective To measure a service screening (Effective Mood Management After Stroke [EMMAS]) long‐term outcomes survivors stroke. Design Cross‐sectional case–control comparison propensity‐score matched samples patients with Setting Tertiary hospital inpatient rehabilitation...

10.1002/pmrj.13372 article EN PM&R 2025-04-21

Depression and anxiety are common comorbidities of stroke. Research has shown that about 30% stroke survivors develop depression 20% anxiety. Stroke with such adverse mental outcomes often attributed to poorer health outcomes, as higher mortality rates. The objective this study is use deep learning (DL) methods predict the risk a survivor experiencing post-stroke and/or anxiety, which collectively known (PSAMO). This studied 179 patients stroke, who were further classified into PSAMO versus...

10.3390/bioengineering12050517 article EN cc-by Bioengineering 2025-05-14

Summary This study attempts to identify the incidence and specific sources of anxiety in parents children admitted hospital for elective surgery, isolate factors associated with increased useful ameliorative measures. One hundred were interviewed completed a questionnaire before their child's surgery. Parental levels measured using Leeds scale self‐assessment anxiety. Anxiety‐related illness was identified 47% parents, who significantly more concerned than others about all aspects children's...

10.1111/j.1365-2044.1996.tb14992.x article EN Anaesthesia 1996-11-01

Uncertainties related to COVID-19 have strained the mental health of healthcare workers (HCWs) worldwide. Gaining ability adapt and thrive under pressure will be key addressing this. We explore what characterises risk, vulnerability resilient responses HCWs during early stages outbreak in Singapore.We undertook qualitative theory-guided thematic analysis e-diary entries from who navigated June-August 2020. Data were extracted a subset an online survey n = 3616 participants collected across 9...

10.1186/s12960-022-00756-7 article EN cc-by Human Resources for Health 2022-07-15

Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed develop a brief clinically feasible battery screen HIV-associated disorders (HAND) resource-limited settings even where English is not the native language. A total 53 outpatients were recruited from multi-ethnic Southeast Asian...

10.1186/s12981-019-0224-4 article EN cc-by AIDS Research and Therapy 2019-04-15

Objective: Sleep–wake disturbances, such as excessive daytime somnolence (EDS), are nonmotor symptoms of Parkinson's disease (PD) and significantly affect the quality life. This study aimed to examine relationship between EDS motor PD. Methods: Eighty-two patients with idiopathic mild PD were followed up twice a year for 2 years assessed on sleep, mood, anxiety, cognition, function, severity. Data analyzed retrospectively, comparing outcomes those without. Results: At baseline, 27.9% had...

10.1177/0891988719892326 article EN Journal of Geriatric Psychiatry and Neurology 2019-12-13

(1) Background: As COVID-19 transmission continues despite vaccination programs, healthcare workers (HCWs) face an ongoing pandemic response. We explore the effects of this on Heartware, by which we refer to morale and commitment HCWs; identify how improve (2) Hardware, or ways enabling operational safety functioning. Methods: Qualitative e-diary entries were shared HCWs during early phases outbreak in Singapore from June August 2020. Data collected via online survey n = 3616 all cadres....

10.3390/ijerph19042477 article EN International Journal of Environmental Research and Public Health 2022-02-21

Introduction: HIV-associated neurocognitive disorders (HAND) comprise a wide spectrum of cognitive, motor, and mood abnormalities prevalent in people living with HIV AIDS (PLWHAs). This field medicine has gained renewed prominence recent years evidence contending that anti-retroviral agents increased central nervous system (CNS) penetration may improve outcomes those affected. review aims at evaluating the available postulating further study direction Singapore. Materials Methods: A PubMed...

10.47102/annals-acadmedsg.v42n10p527 article EN Annals of the Academy of Medicine Singapore 2013-10-15

Psychosis is a prominent neuropsychiatric symptom of Parkinson's disease (PD) and associated with negative outcomes, such as poorer quality life greater rate functional impairment. Early identification patients PD at risk developing psychosis facilitates appropriate management to improve outcomes. However, this phenomenon has not been examined locally. This study aimed examine the prevalence PD-associated in local setting, identify any factors, well characterise cognitive trajectory...

10.11622/smedj.2021182 article EN cc-by-nc-sa Singapore Medical Journal 2021-12-15

Objective To measure the psychological well-being of healthcare workers (HCWs) during this COVID-19 pandemic and examine experiences subgroup participants who were also HCWs 2003 SARS epidemic. Design Anonymous online survey adapted from a similar study conducted epidemic, disseminated July 2020 to August 2020. Setting Nine institutions across Singapore ranging primary care, community tertiary care specialised referral centres. Participants Employees working in participating institutions....

10.1136/bmjopen-2021-051895 article EN cc-by-nc-nd BMJ Open 2021-11-01

Objectives Research suggests a high prevalence of depression and anxiety in people living with HIV, resulting negative health outcomes poorer help-seeking behaviours when undetected. Subsequent disease progression non-adherence to treatment constitute significant barrier HIV treatment. This paper aims identify the risk factors for development psychological distress antiretroviral medication HIV. Methods An outpatient clinical service screened depressive symptoms. As part retrospective...

10.1136/sextrans-2021-055153 article EN cc-by-nc Sexually Transmitted Infections 2021-12-15

Singapore is a geographically small nation-state that has transformed itself from third-world country to developed nation after attaining political independence 46 years ago. The pace of change been tremendous and mental health care no exception. This paper provides an overview review key legislation, including National Mental Health Blueprint was rolled out in 2007. On this background, the focuses on description forensic psychiatric services Singapore. role Department Forensic Psychiatry at...

10.1111/appy.12033 article EN Asia-Pacific Psychiatry 2013-02-25

Introduction: COVID-19 restrictions and lockdown measures have led to impact on the mental health social service delivery, including rapid adoption of digital solutions healthcare delivery in Singapore. This study aims rapidly document quantitative qualitative pandemic services. Method: descriptive mixed-methods consisted a survey arm arm. Providers clients from eligible organisations agencies were recruited. The respondents completed changes their extent clients. In-depth interviews also...

10.47102/annals-acadmedsg.2022332 article EN Annals of the Academy of Medicine Singapore 2023-05-30

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Lin Y, Dhaliwal J, Kong A, Chan L, Tan P. HIV-related stigma as perceived by HIV-positive individuals in Singapore. HIV & AIDS Review. International Journal of HIV-Related Problems. 2017;16(3):176-182. doi:10.5114/hivar.2017.70711. APA Lin, Y., Dhaliwal, J., Kong, A., Chan, L., Tan, (2017). Problems, 16(3), 176-182. https://doi.org/10.5114/hivar.2017.70711 Chicago Yijun Carol, Jaspal Singh Adele Zi Hing Lai...

10.5114/hivar.2017.70711 article EN cc-by-nc-sa HIV & AIDS Review 2017-10-05
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