A5068588827- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Diet, Metabolism, and Disease
- Misinformation and Its Impacts
- Climate Change Communication and Perception
- Metal complexes synthesis and properties
- Metabolism, Diabetes, and Cancer
- Risk Perception and Management
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Antimicrobial Peptides and Activities
- Ethnobotanical and Medicinal Plants Studies
- Liver Disease Diagnosis and Treatment
- Phytochemical and Pharmacological Studies
- Phytochemicals and Medicinal Plants
- Tannin, Tannase and Anticancer Activities
- Phenothiazines and Benzothiazines Synthesis and Activities
- Social Media and Politics
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activity of medicinal plants
- Heavy metals in environment
- Antibiotic Resistance in Bacteria
- Advances in Cucurbitaceae Research
- Synthesis and Biological Evaluation
- Genomics, phytochemicals, and oxidative stress
University of Botswana
2016-2025
Botswana International University of Science and Technology
2023-2024
Abstract Science is crucial for evidence-based decision-making. Public trust in scientists can help decision makers act on the basis of best available evidence, especially during crises. However, recent years epistemic authority science has been challenged, causing concerns about low public scientists. We interrogated these with a preregistered 68-country survey 71,922 respondents and found that most countries, people agree should engage more society policymaking. variations between within...
Abstract Science is integral to society because it can inform individual, government, corporate, and civil decision-making on issues such as public health, new technologies or climate change. Yet, distrust populist sentiment challenge the relationship between science society. To help researchers analyse science-society nexus across different geographical cultural contexts, we undertook a cross-sectional population survey resulting in dataset of 71,922 participants 68 countries. The data were...
This 68-country survey (n = 71,922) examines how people encounter information about science and communicate it with others, identifies cross-country differences, tests the extent to which economic sociopolitical conditions predict such differences. We find that social media are most used sources of in countries, except those democratic-corporatist systems where news tend be more widely. People collectivist societies less outspoken daily life, whereas low education is associated higher...
Contamination of vegetables with toxic metals is one the most important contributing factors to ill health throughout world, more so because are considered essential for human and their consumption highly recommended by authorities. The aim this study was determine concentrations selected elements (Fe, Cu, Mn, Mo, Zn) (As, Cd, Cr, Pb) in common sold supermarkets open market Maun village, Botswana. Five (cabbage, rape, tomatoes, onions potatoes) were purchased from different selling points,...
Objectives: This study aimed to evaluate the hypoglycemic effects of an ethanol extract Cassia abbreviata (ECA) bark and possible mechanisms its action in diabetic albino rats.Methods: ECA was prepared by soaking powdered plant material 70% ethanol.It filtered made solvent-free evaporation on a rotary evaporator.Type 2 diabetes induced rats injecting 35 mg/ kg body weight (bw) streptozotocin after having fed high-fat diet for weeks.Diabetic were divided into ECA-150, ECA-300 Metformin...
Oxidative stress plays a major role in the pathogenesis of many diseases like diabetes, cancer, cardiovascular diseases, and neurodegenerative diseases. has become potential for therapeutic target prevention management such This spiked interest use natural antioxidants disease prevention. The present study was aimed at assessing antioxidant cytotoxic properties sequentially extracted Euclea natalensis leaf extracts. total phenolics flavonoids were estimated, activity determined using...
Aim The study was conducted to screen the ethanol extract of Sida rhombifolia leaves for its phytochemical constituents and elucidate some possible mechanism action in lowering hyperglycemia. Methodology The prepared effect carbohydrate hydrolyzing enzymes (α-amylase α-glucosidase) both vitro vivo, glucose uptake by muscle tissues investigated. Qualitative screening also conducted. Results Sida contained bioactive phytochemicals showed significant dose dependent inhibition α-amylase...
Background:: Repeated heating of cooking oils induces the overproduction reactive oxygen species with an overwhelmed cellular antioxidant defense system, resulting in oxidative stress, known cause cardiovascular diseases. Elaeodendron transvaalense is a medicinal plant believed to have phytochemicals that help ameliorate effects stress. Objective:: This study investigated pro-oxidant repeatedly heated sunflower oil and possible ameliorative potential leaf powder Sprague Dawley rats....
Background:: Postprandial hyperglycemia is a key factor in type 2 diabetes, and its management critical alleviating the deleterious consequences of diabetes associated micro macrovascular complications. Objective:: The current study aims to determine effect Euclea natalensis leaf extracts on α- glucosidase inhibition vitro postprandial vivo rats. Methods:: Sequentially extracted were evaluated for their inhibitory effects α-glucosidase suppression normoglycemic fingerprinted using...
Euclea natalensis is a commonly used plant in traditional African medicine for treating several diseases, including diabetes. The objective of the present study was to evaluate antidiabetic effects leaf extracts and elucidate some its mechanisms action. High-fat diet – low Streptozotocin-induced diabetic Sprague Dawley rats were orally treated with methanol dichloromethane (100 200 mg/kg bw), their fasting blood glucose levels, body weights, food water intake measured every seven days 21...
Diabetes, a chronic metabolic disorder with increasing global prevalence, poses significant public health concern, necessitating the development of safe and effective drugs. This study specifically assessed inhibitory effects Euclea natalensis leaf extracts on alpha-amylase through in vitro, vivo, silico methods. The were sequentially obtained using solvents graded polarity. inhibition studies conducted spectrophotometric methods, while vivo assessments performed starch tolerance test rats....
Oxidative stress has been linked to a wide array of health-debilitating diseases. To alleviate oxidative stress, antioxidants especially plant origin are desired due their potency and low toxicity. The current study, therefore, evaluated the antioxidant properties cytoprotective effects Terminalia prunioides pods. Hexane, chloroform, ethyl acetate methanol extracts from pods were for flavonoid total phenol contents. Their on 2, 2-diphenyl-1-picryl hydrazyl (DPPH), 2,2’-azino-bis...
Several medicinal plants have anti-diabetic properties and can be considered as an alternative therapy because of their actions which are like those conventional antidiabetic drugs. In this study, we investigated Myrothamnus flabellifolius (MF) ethanol: water (70:30) extract for its possible potential in streptozotocin-high energy diet (STZ-HED) induced type 2 diabetes mellitus (T2DM) rats mechanisms action. Diabetic were divided into MF-50, MF-100, MF200, MF-300, MF-400, Metformin (MET)-500...