A5079692502- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Toxin Mechanisms and Immunotoxins
- Advanced biosensing and bioanalysis techniques
- Toxoplasma gondii Research Studies
- RNA regulation and disease
- Renal and related cancers
- RNA modifications and cancer
- Congenital Diaphragmatic Hernia Studies
- Urological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Virus-based gene therapy research
- Viral-associated cancers and disorders
University of Manchester
2020-2023
University of Cambridge
2015-2020
The tegument of herpesviruses is a highly complex structural layer between the nucleocapsid and envelope virions. Tegument proteins play both regulatory functions during replication spread, but interactions many these are poorly understood. Here we focus on two from herpes simplex virus 1 (HSV-1), pUL7 pUL51, which have homologues in all other herpesviruses. We now identified that HSV-1 pUL51 form stable direct protein-protein interaction, their expression levels rely presence each other,...
Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a molecular mechanism that remains unclear. Herpes simplex virus (HSV)−1 proteins pUL7 and pUL51 form complex required for efficient envelopment. We show interaction between homologues is conserved across human herpesviruses, as association with trans-Golgi membranes. characterized HSV-1 pUL7:pUL51 by solution scattering chemical crosslinking, revealing 1:2 can higher-order oligomers solution, we solved...
ZMYM2 is a zinc finger transcriptional regulator that plays key role in promoting and maintaining cell identity. It has been implicated several diseases such as congenital anomalies of the kidney where its activity diminished cancer it participates oncogenic fusion protein events. thought to function through repression here we provide more evidence support this designation. Here studied human cells demonstrate part distinct chromatin-bound complexes including established LSD1-CoREST-HDAC1...
ZMYM2 is a zinc finger transcriptional regulator that plays key role in promoting and maintaining cell identity. It has been implicated several diseases such as congenital anomalies of the kidney where its activity diminished cancer it participates oncogenic fusion protein events. thought to function through repression here we provide more evidence support this designation. We demonstrate part distinct chromatin-bound complexes including established LSD1-CoREST-HDAC1 corepressor complex...
Abstract ZMYM2 is a zinc finger transcriptional regulator that plays key role in promoting and maintaining cell identity. It has been implicated several diseases such as congenital anomalies of the kidney where its activity diminished cancer it participates oncogenic fusion protein events. thought to function through repression here we provide more evidence support this designation. Here studied human cells demonstrate part distinct chromatin-bound complexes including established...
Abstract Herpesviruses are an ancient family of highly-prevalent human and animal pathogens that acquire their membrane envelopes in the cytoplasm infected cells. While multiple conserved viral proteins known to be required for efficient herpesvirus production, many these lack identifiable structural homologues molecular details assembly remain unclear. We have characterized complex pUL7 pUL51 from herpes simplex virus (HSV)-1, α-herpesvirus, using multi-angle light scattering small-angle...
ZMYM2 is a zinc finger transcriptional regulator that plays key role in promoting and maintaining cell identity. It has been implicated several diseases such as congenital anomalies of the kidney where its activity diminished cancer it participates oncogenic fusion protein events. thought to function through repression here we provide more evidence support this designation. Here studied human cells demonstrate part distinct chromatin-bound complexes including established LSD1-CoREST-HDAC1...
ZMYM2 is a zinc finger transcriptional regulator that plays key role in promoting and maintaining cell identity. It has been implicated several diseases such as congenital anomalies of the kidney where its activity diminished cancer it participates oncogenic fusion protein events. thought to function through repression here we provide more evidence support this designation. Here studied human cells demonstrate part distinct chromatin-bound complexes including established LSD1-CoREST-HDAC1...