A5022678677- Legionella and Acanthamoeba research
- Heme Oxygenase-1 and Carbon Monoxide
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Enterobacteriaceae and Cronobacter Research
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Toxoplasma gondii Research Studies
- HIV/AIDS drug development and treatment
- Infant Nutrition and Health
- Hepatitis C virus research
- HIV Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Tea Polyphenols and Effects
- Probiotics and Fermented Foods
Kansas State University
2018-2025
University of Cincinnati Medical Center
2020
ABSTRACT The emergence and global spread of carbapenem-resistant Enterobacter cloacae complex species present a pressing public health challenge. Carbapenem-resistant spp. cause wide variety infections, including septic shock fatalities in newborns immunocompromised adults. intestine may be major reservoir for these resistant strains, either by facilitating contamination fomites transfer to susceptible individuals, or through translocation from the gut bloodstream. For this reason, we sought...
Legionella pneumophila is ubiquitous in freshwater environments, where it replicates within unicellular protozoa. However, L. also an accidental human pathogen that can cause Legionnaires' disease immunocompromised individuals by uncontrolled replication alveolar macrophages. To replicate eukaryotic phagocytes, utilizes a Dot/Icm type IV secretion system to translocate large arsenal of over 300 effector proteins directly into host cells. In mammals, translocated effectors contribute innate...
ABSTRACT Polyphenols derived from a variety of plants have demonstrated antimicrobial activity against diverse microbial pathogens. Legionella pneumophila is an intracellular bacterial pathogen that opportunistically causes severe inflammatory pneumonia in humans, called Legionnaires’ Disease, via replication within macrophages. Previous studies tea polyphenols attenuate L. mouse macrophages increased tumor necrosis factor (TNF) production. Sorghum bicolor sustainable cereal crop thrives...
Viral diversity is an important feature of hepatitis C virus (HCV) infection and predictor disease progression treatment response. HIV/HCV co-infection associated with enhanced HCV replication, increased fibrosis, the development liver disease. HIV also increases quasispecies structural genes, although limited data are available regarding impact on non-structural genes HCV, particularly in absence direct-acting therapies. The genetic presence drug resistance mutations within RNA-dependent...
Legionella pneumophila is a natural pathogen of amoebae that causes Legionnaires' Disease in immunocompromised individuals via replication within macrophages. L. virulence and intracellular hinges on hundreds Dot/Icm-translocated effector proteins, which are essential for biogenesis the replication-permissive Legionella-containing vacuole (LCV). However, activity can also enhance mammalian host defense effector-triggered immunity. The LegC4 important but enhances against mouse lung and,...
The emergence and global spread of carbapenem-resistant
Legionella pneumophila is ubiquitous in freshwater environments where it replicates within unicellular protozoa. However, L. also an accidental human pathogen that can cause Legionnaires’ Disease immunocompromised individuals by uncontrolled replication alveolar macrophages. To replicate eukaryotic phagocytes, utilizes a Dot/Icm type IV secretion system to translocate large arsenal of over 300 effector proteins directly into host cells. In mammals, translocated effectors contribute innate...
Abstract Legionella pneumophila is a natural pathogen of amoebae that causes Legionnaires’ Disease in immunocompromised individuals via replication within macrophages. L. virulence and intracellular hinges on hundreds Dot/Icm-translocated effector proteins, which are essential for biogenesis the permissive -containing vacuole (LCV). However, activity can also enhance mammalian host defense effector-triggered immunity. The LegC4 important but enhances against mouse lung and, uniquely,...