A5083181792- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Muscle metabolism and nutrition
- HIV/AIDS Research and Interventions
- Veterinary Equine Medical Research
- HIV-related health complications and treatments
- Opioid Use Disorder Treatment
- Sports Performance and Training
- HIV Research and Treatment
- Medication Adherence and Compliance
- Renal function and acid-base balance
- Chronic Lymphocytic Leukemia Research
- Ion Transport and Channel Regulation
- Diet and metabolism studies
- Pharmacological Effects and Assays
- Sex work and related issues
- Anesthesia and Pain Management
- Otitis Media and Relapsing Polychondritis
- Homelessness and Social Issues
- Nursing Education, Practice, and Leadership
- Advanced Causal Inference Techniques
- Exercise and Physiological Responses
University of Rhode Island
2019-2025
Providence College
2003-2023
University of Washington
2023
Behavioral Health Services
2020-2022
Colorado State University
2005-2021
Miriam Hospital
2006-2020
Brown University
2009-2020
University of Pennsylvania
1998-2019
Centenary College of New Jersey
2019
Oregon Health & Science University
2017
The aim of this study was to systematically evaluate state Medicaid policies for the treatment hepatitis C virus (HCV) infection with sofosbuvir in United States. reimbursement criteria were evaluated all 50 states and District Columbia. authors searched Web sites between 23 June 7 December 2014 extracted data duplicate. Any differences resolved by consensus. Data on whether covered coverage based following categories: liver disease stage, HIV co-infection, prescriber type, drug or alcohol...
We conducted a study to determine the prevalence and factors associated with hepatic steatosis in human immunodeficiency virus (HIV)-seropositive patients hepatitis C investigate whether is liver fibrosis. Retrospective chart reviews were 4 hospitals that serve community-based incarcerated HIV-infected who had undergone biopsy for evaluation of (HCV) infection during period 2000-2003. Demographic characteristics medication laboratory data collected from time biopsy. A pathologist blinded all...
In the developed world, majority of new and existing hepatitis C virus (HCV) infections occur among people who inject drugs (PWID). The burden HCV-related liver disease in this group is increasing, but treatment uptake PWID remains low. Among PWID, there are a number barriers to care that should be considered systematically addressed, these not exclude from HCV treatment. Furthermore, it has been clearly demonstrated safe effective across broad range multidisciplinary healthcare settings....
Abstract Background Hepatitis C virus (HCV) is a leading cause of infectious disease death in the United States. Although highly effective direct-acting antiviral (DAA) regimens are well established, retreatment among people who inject drugs (PWID) has not been sufficiently studied. This study assessed DAA outcomes and associated factors. Methods We performed analyses longitudinal data from HERO Study, US-based multi-site pragmatic randomized trial conducted 8 states to evaluate...
Background: Approximately 1 in 4 of the nearly 2 million individuals state and federal correctional facilities are infected with hepatitis C virus (HCV). Currently, there few reports treatment outcomes this common infection setting. Objective: To describe HCV therapy incarcerated Design: Retrospective, descriptive observational study. Setting: Rhode Island Department Corrections, Cranston, Island. Patients: 93 inmates chronic infection. Intervention: Interferon- ribavirin. Measurements: RNA...
Background. FIB-4 represents a noninvasive, composite index that is validated measure of hepatic fibrosis, which an important indicator liver disease. To date, there are limited data regarding fibrosis in women. Methods. was evaluated cohort 1227 women, and associations were univariate multivariate regression models among 4 groups subjects classified by their human immunodeficiency virus (HIV) hepatitis C (HCV) infection status. Results. The median scores 0.60 HIV-/HCV- 0.83 HIV-/HCV+ 0.86...
<h3>Background:</h3> In Canada, interferon-free, direct-acting antiviral hepatitis C virus (HCV) regimens are costly. This presents challenges for universal drug coverage of the estimated 220 000 people with chronic HCV infection nationwide. The study objective was to appraise criteria reimbursement 4 antivirals in Canada. <h3>Methods:</h3> We reviewed simeprevir, sofosbuvir, ledipasvir<b>-</b>sofosbuvir and paritaprevir<b>-</b>ritonavir<b>-</b>ombitasvir plus dasabuvir 10 provinces 3...
IMPORTANCE Hepatitis C virus (HCV) reinfection after curative treatment remains a concern for people who inject drugs. OBJECTIVE To assess the incidence of HCV and associated risk factors. DESIGN, SETTING, AND PARTICIPANTS This cohort study is secondary analysis randomized clinical trial that was conducted across opioid programs community health centers in US between September 2016 August 2018. The current analyses were performed March 2022. People drugs achieved sustained virologic response...
HIV-1 associated neurocognitive disorders (HAND) develop during progressive infection and affect up to 50% of infected individuals. Activated microglia macrophages are critical cell populations that involved in the pathogenesis HAND, which is specifically related production release various soluble neurotoxic factors including glutamate. In central nervous system (CNS), glutamate typically derived from glutamine by mitochondrial enzyme glutaminase. Our previous study has shown glutaminase...
Outbreaks of sexually transmitted hepatitis C virus (HCV) infection have been reported among human immunodeficiency (HIV)-infected men who sex with in Europe, Australia, and New York. Whether this is occurring across the United States unknown. We determined incidence HCV during 1996-2008 male participants AIDS Clinical Trial Group Longitudinal Linked Randomized Trials cohort, a long-term study HIV-infected persons randomized into selected US-based clinical trials. evaluated associations...
More than half of cancer patients are treated with radiotherapy, which kills tumor cells by directly and indirectly inducing DNA damage, including cytotoxic double-strand breaks (DSBs). Tumor respond to these threats activating a complex signaling network termed the damage response (DDR). The DDR arrests cell cycle, upregulates repair, triggers apoptosis when is excessive. repair pathways fertile terrain for therapeutic intervention. This review highlights strategies improve gain targeting...
Summary High intensity exercise is associated with production of energy by both aerobic and anaerobic metabolism. Conditioning repeated increases the maximal rate metabolism, capacity, horses, but whether amount provided can be increased conditioning horses unknown. We, therefore, examined effects 10 weeks regular (4–5 days/week) high (92 ± 3 %V̇O 2max ) on accumulated oxygen deficit 8 Standardbred that had been confined to box stalls for 12 weeks. Exercise resulted in 17% V̇O (P<0.001),...
To determine effects of feeding diets with various soluble-carbohydrate (CHO) content on rates muscle glycogen synthesis after exercise in horses.7 fit horses.In a 3-way crossover study, horses received each 3 isocaloric (a high soluble CHO [HC] diet, low [LC] or mixed [MC] diet). For were subjected to glycogen-depleting exercise, followed by the HC, LC, MC diet at 8-hour intervals for 72 hours.Feeding HC resulted significantly higher glycemic response hours and greater concentration 48...
Proximal tubules were isolated from control and acidotic rats by collagenase digestion Percoll density gradient centrifugation. Western blot analysis indicated that the approximately 95% pure. The samples analyzed two-dimensional difference gel electrophoresis (DIGE) DeCyder software was used to quantify temporal changes in proteins exhibit enhanced or reduced expression. mass-to-charge ratios amino acid sequences of recovered tryptic peptides determined MALDI-TOF/TOF mass spectrometry...
Background. Sexually transmitted hepatitis C virus (HCV) infection is an emerging epidemic among human immunodeficiency (HIV)–infected men who have sex with (MSM). HCV may be underrecognized in this population, historically thought to at low risk.