Background and objectives Recent studies have reported an increasing incidence of anxiety among adolescent girls, associated this with self-reported social media use. This study aimed to measure smartphone use objectively evaluate its associations measures mental health well-being. Methods In autumn 2022, we recruited a cohort 1164 first-year female students from 21 socioeconomically diverse high schools. Students responded online survey comprising validated questionnaires (Bergen Social...

Ipratropium is a parasympatholytic agent with high topical activity. The effect of intranasal ipratropium was studied in 34 patients who were over 60 years age and suffered from chronic watery vasomotor rhinorrhoea. study double-blind cross-over placebo controlled trial. Trial parameters were: daily nasal symptom side scores, methacholine testing before after treatment, clinical evaluation. active drug clearly reduced discharge. Nasal showed reduction secretion the treatment period. majority...

Abstract Introduction Giant prolactinomas are rare, especially in children and adolescents often resistant to the recommended first-line cabergoline monotherapy. In addition, possible second line guideline treatment recommendations (surgery, radiotherapy, temozolomide) not suitable. Clinical Case A 14-year-old girl (51kg/155,7cm/BMI 18.4 kg/m2, bone age 14.37) was referred pediatric endocrinologist because of primary amenorrhea delayed puberty. Two years earlier, she underwent a brief...

Objective Among adolescents, amenorrhea is a common reason for medical consultation. Despite the variety of underlying etiologies, prevalence causes incompletely understood. This study aimed to assess demographic and etiological factors among patients with treated in single specialist unit adolescent gynecology. Design Retrospective register study. Methods Medical records 438 girls evaluated primary or secondary tertiary care center between 2015 2019 were retrospectively reviewed. In all,...

Inborn errors of immunity offer important insights into mucosal immunity. In autoimmune polyendocrine syndrome type-1 (APS-1), chronic mucocutaneous candidiasis has been ascribed to neutralizing IL-17 autoantibodies. Recent evidence implicates excessive T-cell IFN-γ secretion and ensuing epithelial barrier disruption in predisposition candidiasis, but these results remain be replicated. Whether paucity, increased type I inflammation, or their combination underlies susceptibility mucocutaneus...

From a previous sample of 634 students and school children, 115 subjects were selected for thorough rhinological examination allergy work‐up in order to assess the value nasal secretion eosinophilia screening immediate‐type allergy. Part had, study, been found have history chronic/allergic rhinitis, part had either or rhinitis history, them neither nor history. A significant correlation was obtained between Nasal provocation tests correlated with skin 87%, whereas IgE determinations serum...

The aim of the study was to investigate urine matrix metalloproteinase (MMP-2 and -9) activity, alkaline phosphatase/creatinine (U-AP/Cr) gamma-glutamyl-transpeptidase/creatinine (U-GGT/Cr) ratios, glucose concentration, protein/creatinine (U-Prot/Cr) ratio compare data with plasma MMP-2 -9 cystatin-C creatinine concentrations in colic horses healthy controls. Horses surgical (n = 5) were compared stallions 7) that came for castration. Blood samples collected. MMP gelatinolytic activity...

A follow-up study was carried out in 87 patients who received intra-nasal BDP therapy during 1–6 years (mean 5 years) for perennial allergic rhinitis. The initial dose of 400 μg/day but long-term use a 2–300 sufficient to maintain control nasal symptoms 69 % the patients. 74/87 remained completely or almost symptomfree when continuing therapy. 13 used antihistaminics addition BDP. caused no adverse effects 44 while commonest side-effect remaining 43 drying mucosa. In randomly selected...

Allergological, clinical and histological findings in 109 unselected patients, treated for nasal polyps during the period Feb. 1977 to 1978 are reported. The material was divided into three groups according findings: 1) Atopy Group; 18 patients with positive history skin test; 2) ASA Intolerance 25 a definite of acetylsalicylic acid intolerance; 3) Intrinsic Disease 66 whom specific etiological factors were not found. On testing, reactions obtained 42 patients. In 23 test result agreed...

Advances in multimodality cancer treatments have increased long-term survival rates for early onset patients, with 5-year reaching 80% Northern Europe. According to recent recommendations, clinicians should, as possible, inform patients about the impact that treatment may on their fertility. Still, there is limited published data fertility counselling (FC) and preservation (FP) patients.

The aim of this study was to identify pitfalls in ovarian tissue cryopreservation protocol from referral surgical procedure and analyze factors associated with chemotherapy exposure the cryopreserved decreased function a cohort young girls at high risk infertility. population comprised 200 eligible for between 2002 2020 Children's Hospital University Central Helsinki (Finland). Analyses included evaluation proportion patients who underwent cryopreservation, patient selection timing during...

Biallelic, partial loss-of-function mutations in GNRHR cause a wide spectrum of reproductive phenotypes from constitutional delay growth and puberty to complete congenital hypogonadotropic hypogonadism. We studied the frequency GNRHR, FGFR1, TAC3, TACR3 nine adolescent young adult females with clinical cues consistent gonadotropin deficiency (stalled puberty, unexplained secondary amenorrhea), describe phenotypic features molecular genetic findings monozygotic twin brothers stalled puberty....

The effect of locally acting intra-nasal beclomethasone dipropionate was observed in 42 patients suffering from seasonal allergic rhinitis and 50 perennial rhinitis. study consists three parts: 1) a simple double-blind trial rhinitis, 2) crossover 3) 1-year follow-up the group. active drug significantly superior to placebo when comparing subjective symptoms, nasal resistance secretion eosinophilia patients. In long-term use it possible reduce initial dose considerably. On objective...

To determine the natural course of pubertal development, growth during puberty, and development POI in females with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also called polyendocrine syndrome type I.Longitudinal follow-up study.A national cohort APECED aged ≥12 years were followed 1965-2018. Attainment adult height was defined when patients' increased less than 1 cm per year. Diagnosis based on delayed puberty or symptoms amenorrhea, and/or FSH ≥40...

AbstractNasal reactions to unilateral allergen provocation were studied separately in both nasal cavities of 9 subjects with established seasonal allergic rhinitis. Three tests the same at concentration performed cavity 48-h intervals. The parameters observed clinical symptoms, changes airway resistance on rhinomanometry, and amount, weight histamine content collected secretion. Nasal obstruction increased significantly provoked side but not contralaterally. Secretion symmetrically rose only...

Simultaneous conjunctival and nasal provcation tests, a total of 174 test pairs, were carried out in fifty patients with allergic rhinitis, using serially diluted antigen solutions birch, Timothy grass mugwort pollen, as well cat dog dander. The mucosa was found to be more sensitive than the ninety-six pairs (55%). This differs from earlier reports. Nasal reaction only observed twenty-nine instances (17%). Posterior rhinomanometry also used evaluate reactions, but yield little additional...

Skin tests and bronchial, nasal conjunctival provocation with pollen animal dander allergens were performed in thirty patients atopic asthma. In vivo test results compared only when the same batch of allergen had been used. A reaction was mostly elicied at a lower concentration than needed to elicit bronchial (P less 0.01). Positive reactions often obtained corresponding negative. The conjunctiva reacted concentrations bronchi third instances testing, most these being mugwort 0.05). positive...