A5056437708- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- Knee injuries and reconstruction techniques
- Gut microbiota and health
- Exercise and Physiological Responses
- Oral microbiology and periodontitis research
- Obsessive-Compulsive Spectrum Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mobile Health and mHealth Applications
- Family Business Performance and Succession
- Salivary Gland Disorders and Functions
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Muscle Physiology and Disorders
- Neuropeptides and Animal Physiology
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Medicinal plant effects and applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Protease and Inhibitor Mechanisms
- Stress Responses and Cortisol
- Circular RNAs in diseases
- Rheumatoid Arthritis Research and Therapies
University of Catania
2018-2022
Circular RNAs are a large group of whose cellular functions still being investigated. We recently proposed that circSMARCA5 acts as sponge for the splicing factor Serine and Arginine Rich Splicing Factor 1 (SRSF1) in glioblastoma multiforme (GBM). After demonstrating by RNA immunoprecipitation physical interaction between SRFS1 circSMARCA5, we assayed real-time PCR cohort 31 GBM biopsies 20 unaffected brain parenchyma controls (UC) expression total, pro-angiogenic (Iso8a) anti-angiogenic...
Recent evidence has demonstrated that salivary molecules, as well bacterial populations, can be perturbed by several pathological conditions, including neuro-psychiatric diseases. This relationship between brain functionality and saliva composition could exploited to unveil new mechanisms of elusive diseases, such Autistic Spectrum Disorder (ASD). We performed a combined approach miRNA expression profiling NanoString technology, followed validation experiments in qPCR, 16S rRNA microbiome...
The management of chondral defects represents a big challenge because the limited self-healing capacity cartilage. Many approaches in this field obtained partial satisfactory results. Cartilage tissue engineering, combining innovative scaffolds and stem cells from different sources, emerges as promising strategy for cartilage regeneration. aim study was to evaluate capability cell-free collagen I-based scaffold promote cartilaginous repair after orthotopic implantation vivo. Articular...
Abstract Membranous glomerulonephropathy (MGN) is a glomerulopathy characterized by subepithelial deposits of immune complexes on the extracapillary side glomerular basement membrane. Insertion C5b‐9 (complement membrane‐attack complex) into membrane leads to functional impairment capillary wall. Knowledge molecular pathogenesis MGN actually scanty. MicroRNA (miRNA) profiling in and unaffected tissues was performed TaqMan Low‐Density Arrays. Expression miRNAs miRNA targets evaluated...
Skeletal muscle atrophy, resulting from states of hypokinesis or immobilization, leads to morphological, metabolic, and functional changes within the tissue, a large variety which are supported by stromal cells populating interstitium. Telocytes represent recently discovered population cells, has been increasingly identified in several human organs appears participate sustaining cross-talk, promoting regenerative mechanisms supporting differentiation local stem cell niche. The aim this...
Successful tissue regeneration therapies require further understanding of the environment in which cells are destined to be set. The aim is structure approaches that aspire a holistic view biological systems and scientific reliability. Mesenchymal stem represent valuable resource for cartilage engineering, due their chondrogenic differentiation capacity. Promoting chondrogenesis, not only by growth factors but also exogenous enhancers such as biomechanics, represents technical enhancement....
Due to its rarity, coupled a multifactorial and very heterogeneous nature, the molecular etiology of Arnold-Chiari (AC) syndrome remains almost totally unknown. Its relationship with other neuropsychiatric disorders such as Tourette (TS) is also undetermined. The rare comorbid status between both (ACTS) complicates framework diagnosis negatively affects patients' quality life. In this exploratory study, we aimed identify serum microRNA expression profiles fingerprints for AC, TS, ACTS, by...