A5076105668- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Prion Diseases and Protein Misfolding
- Enzyme Structure and Function
- Virus-based gene therapy research
- Wound Healing and Treatments
- Natural Compound Pharmacology Studies
- Hydrogels: synthesis, properties, applications
- Forensic and Genetic Research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- Bacteriophages and microbial interactions
- Advanced Cellulose Research Studies
- Animal Disease Management and Epidemiology
- Nanocomposite Films for Food Packaging
- Hepatitis B Virus Studies
- Dermatology and Skin Diseases
- Diabetes and associated disorders
- Immune responses and vaccinations
- Trace Elements in Health
- Polysaccharides and Plant Cell Walls
Indonesia International Institute for Life Sciences
2020-2022
Leiden University
2011
Eijkman Institute for Molecular Biology
2011
Australian National University
2001-2004
SARS-CoV-2 and its variants caused the COVID-19 pandemic. Vaccines that target conserved regions of stimulate protective T-cell responses are important for reducing symptoms limiting infection. Seven cytotoxic (CTL) five helper T-cells (HTL) epitopes from ORF1ab were identified using NetCTLpan NetMHCIIpan algorithms, respectively. These generated evolutionary stable as reflected by zero Shannon's entropy presented 56 human leukocyte antigen (HLA) Class I 22 HLA II, ensuring good coverage...
Cellulose-based wound dressings are increasingly in demand due to their biocompatibility and extracellular matrix (ECM) mimicking properties.
We report the first Fourier transform infrared analysis of prion protein (PrP) repeats and study PrP marsupial origin. Large changes in secondary structure an increase hydrogen bonding within peptide groups were evident from a red shift amide I band by >7 cm −1 approximately five‐fold reduction hydrogen–deuterium exchange for interacting with Cu 2+ ions. Changes tertiary upon copper binding also appearance new at 1564 , which arises ring vibration histidine. The copper‐induced...
Reports on T-cell cross-reactivity against SARS-CoV-2 epitopes in unexposed individuals have been linked with prior exposure to the human common cold coronaviruses (HCCCs). Several studies suggested that cross-reactive T-cells response live attenuated vaccines (LAVs) such as BCG (Bacillus Calmette-Guérin), OPV (Oral Polio Vaccine), and MMR (measles, mumps, rubella) can limit development severity of COVID-19. This study aims identify potential between SARS-CoV-2, HCCCs, LAVs context peptides...
Event Abstract Back to Motifs of the naturally processed peptides presented by HLA-A*24:07 Marsia Gustiananda1*, Darryl Cox2, Curtis McMurtrey2, Kenneth W. Jackson2, Danijela Mojsilovic2, Wilfried Bardet2, Fredda Schafer2, Steven Cate2, Jane Yaciuk2, Saghar Kaabinejadian2 and William H. Hildebrand2* 1 Eijkman Institute for Molecular Biology, Indonesia 2 University Oklahoma Health Sciences Center, Microbiology Immunology, United States Class I HLA molecules mediate immune responses presenting...
The current epidemic caused by a novel coronavirus SARS-CoV2 as well two previously documented pandemic SARS-CoV and MERS-CoV imposes that spillover of an animal to humans is continuous threat. zoonotic nature the infection contributes unpredictability pandemic. In such situations, availability ‘off shelf’ vaccines target conserved region might help in preventing spread diseases. Therefore, efforts generate should be considered priority. whole genome readily available public database one...
The mesogenic and velogenic strains of the avian Newcastle Disease Viruses (NDV) have been investigated for use in cancer virotherapy. However, despite its promising results, these potential to cause outbreaks leading morbidity mortality large numbers avians that can devastate poultry industry. Therefore, there is a growing interest towards lentogenic such as NDV LaSota vaccine strain This study oncolytic on colorectal (HT29) cervical (HeLa) cell lines. stain was propagated pathogen free...