A5101411952- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Blood Pressure and Hypertension Studies
- Hemodynamic Monitoring and Therapy
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Non-Invasive Vital Sign Monitoring
- Renal and Vascular Pathologies
- Vascular anomalies and interventions
- Renal function and acid-base balance
- Cardiovascular Disease and Adiposity
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Conditions and Treatments
- Agricultural Economics and Policy
Tokyo University of Agriculture and Technology
2023-2024
Chiba Cerebral and Cardiovascular Center
2010-2023
Sapporo Higashi Tokushukai Hospital
2020-2023
GTx (United States)
2016-2022
Chiba Hospital
2014-2020
Hokkaido University Hospital
2018
St. Luke's International Hospital
2015
Hokkaido University
2002-2014
Boston Children's Hospital
2014
Tokyo Women's Medical University
2000-2002
Andersen-Tawil syndrome (ATS) is a rare inherited disorder characterized by periodic paralysis, mild dysmorphic features, and QT or QU prolongation with ventricular arrhythmias in electrocardiograms (ECGs). Mutations of KCNJ2, encoding the human inward rectifying potassium channel Kir 2.1, have been identified patients ATS. We aimed to clarify genotype-phenotype correlations ATS patients. screened 23 clinically diagnosed from 13 unrelated Japanese families. Ten different forms KCNJ2...
Central blood pressure (CBP) can now be reliably measured noninvasively with a number of devices in adult; however, noninvasive assessment CBP has not been validated children and adolescents. The purpose this study was to clarify the accuracy oscillometric measurements adolescents.This included 60 patients an average age 7.9 ± 4.4 years (range 1-18 years) who underwent cardiac catheterization. We compared CBP, estimated method using Mobil-O-Graph, simultaneous invasive recordings catheter...
After the arterial switch procedure, decreased distensibility of aortic root has been reported, which means impaired reservoir function coronary circulation, but there have no reports regarding relationship this issue to myocardial perfusion. Therefore, in present study and supply-demand balance were examined patients after undergoing operation (ASO) around time entering elementary school.Diastolic runoff (DR), is percentage diastolic blood flow total cardiac output, was measured as index...
Objectives To assess body composition and relationships among composition, appetite-related hormones, adipocytokines, heart failure (HF) in adult patients with congenital disease (CHD). Patients This prospective study enrolled 46 consecutive CHD 12 age-matched healthy controls. The control subjects were divided into four groups: 13 Fontan circulation (group A), 16 cyanosis B), 17 who previously underwent biventricular repair C), Design Body was measured using InBody730, levels of hormones...
The brain of a rhesus monkey that died at 43 years age with symptoms suspected cognitive dysfunction was analyzed. pathological analyses revealed characteristic Alzheimer's disease-related lesions: the aggregation amyloid β (Aβ) in form senile plaques and phosphorylated tau proteins. We also Aβ43, which is prone to toxicity humans, involved monkey, as well several other Aβ species. Comparative studies neuropathology using aged nonhuman primates lack behavioral descriptions compared human...
Although "squatting" in patients with tetralogy of Fallot is famous, the hemodynamic mechanism phenomenon has not been fully elucidated. To clarify squatting, change aortic pulsatile property induced by squatting was investigated.Twelve healthy young adults were enrolled this study. The central pressure waveform investigated using SphygmoCor (PWV Medical, Sydney, Australia).The augmentation index during higher than that standing (mean +/- SEM, 6.3 1.1 v 25.0 1.1; P <.0001). heart rate...
A peripheral pulse pressure (PP) is larger than a central PP (PP amplification). The phenomenon has been examined in adult, but not children.Fifty-four patients with normal aorta were enrolled. ascending and descending waveforms recorded by sensor-mounted catheter. difference of the PP, which was defined as minus that ratio to aortic index amplification.The patient's age 6.2 ± 3.0 years. 4.5 2.7 mmHg had significant positive relationship mean blood (r = 0.46, P 0.0005) 0.36, 0.009). 1.14...
Introduction: One of the most important problems in patients with an aortic coarctation after arch repair is future cardiovascular disease. We previously reported enhancement pressure wave reflection and hypothesized that was caused by a new generated from repaired site. To prove hypothesis, we analyzed waveform ascending descending aorta examined their pulse (PP) amplification. Methods: Fifteen without recoarctation were enrolled. The waveforms recorded sensor mounted catheter. pressures...
After successful surgical repair in patients with aortic coarctation, the early onset of cardiovascular diseases is an important subsequent complication and one causes enhanced pressure wave reflection. Balloon angioplasty has become established as effective alternative to surgery, but there have been no reports regarding reflection after balloon dilatation coarctation. A 29-year-old patient coarctation was admitted for angioplasty, which performed successfully. Six months later, catheter...